Prognostic value of intraductal carcinoma of the prostate in radical prostatectomy specimens

Kimura, Kyosuke; Tsuzuki, Toyonori; Kato, Masashi; Saito, Akiko; Sassa, Naoto; Ishida, Ryoji; Hirabayashi, Hiroki; Yumura, Yasushi; Hattori, Ryohei; Gotoh, Momokazu

doi:10.1002/pros.22786

Cited by 142 publications

(167 citation statements)

References 32 publications

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“…5 Only one group reported that intraductal carcinoma of the prostate was an important adverse pathological parameter that could predict disease progression in metastatic 9,24 however, their results relied on univariate analysis. We showed that the incidence of intraductal carcinoma of the prostate was 36.3% in needle biopsies and 50.5% in radical prostatectomy specimens of high-risk prostate cancer patients, 6 and that the incidence rose to 67% in patients with distant metastasis at initial diagnosis. Visceral metastasis, performance status, pain, and hemoglobin and alkaline phosphatase levels were proposed as prognostic parameters for overall survival in the TAX327 study.…”

Section: Discussionmentioning

confidence: 84%

“…The median serum PSA was 328 ng/ml (range 4.18-10 992 ng/ml). The median-submitted number of cores was six (mean 7.3, range [1][2][3][4][5][6][7][8][9][10][11][12][13][14] and the median number of cancer-positive cores was six (mean 5.8, range [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Intraductal carcinoma of the prostate was detected in 100 (67%) patients, six with PSA levels o 20 ng/ml and the remaining 94 with PSA levels 420 ng/ml.…”

Section: Resultsmentioning

confidence: 99%

“…4,10,23 Our group was the first to report that the presence of intraductal carcinoma of the prostate is the only prognostic factor of high-risk prostate cancer on radical prostatectomy for both progression-free survival and cancer-specific survival. 6 Moreover, the presence of intraductal carcinoma of the prostate is reported to be an independent prognostic parameter of early PSA progression-free survival after radiation therapy. 5 Only one group reported that intraductal carcinoma of the prostate was an important adverse pathological parameter that could predict disease progression in metastatic 9,24 however, their results relied on univariate analysis.…”

Section: Discussionmentioning

confidence: 99%

“…3,6 Briefly, intraductal carcinoma of the prostate is exemplified by well-circumscribed lesions bound by intact basal cells distended by overtly malignant-appearing epithelial populations. These lumen-spanning lesions are found almost exclusively in close proximity to invasive tumors.…”

Section: Definition Of Intraductal Carcinoma Of the Prostatementioning

confidence: 99%

“…7 We recently showed that the presence of intraductal carcinoma of the prostate could be an adverse prognostic parameter for both clinical progressionfree survival, cancer-specific survival, and overall survival in radical prostatectomy cases. 6 Using univariate analysis, Zhao et al 9 demonstrated that intraductal carcinoma of the prostate could influence clinical outcome in prostate cancer patients with distant metastasis at initial presentation. However, whether the presence of intraductal carcinoma of the prostate is an independent prognostic parameter to predict outcome, including among clinical parameters, is still unclear.…”

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confidence: 99%

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The presence of intraductal carcinoma of the prostate in needle biopsy is a significant prognostic factor for prostate cancer patients with distant metastasis at initial presentation

et al. 2016

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Intraductal carcinoma of the prostate is an adverse prognostic factor in localized prostate cancer patients. However, whether it influences outcome of those patients with distant metastases discovered at initial diagnosis is unclear. Here, we evaluated whether the presence of intraductal carcinoma of the prostate in prostate needle biopsies is an adverse prognostic factor for cancer-specific survival and overall survival in such prostate cancer patients. We retrospectively enrolled 150 eligible patients. All patients received androgen-deprivation therapy and/or chemotherapy. Their age, performance status, pain, metastatic sites, clinical T stage, serum prostatespecific antigen, alkaline phosphatase, hemoglobin, Gleason score, and the presence of Gleason pattern 5 were analyzed. Primary end point was cancer-specific survival; secondary end points included prostate-specific antigen progression-free survival and overall survival. Fine and Gray's model and the Cox proportional hazards model were used as statistical tests. Intraductal carcinoma of the prostate was detected in 100 (67%) patients. At a median follow-up of 38 months, 79 patients (53%) had died of the disease and nine (6%) had died of other causes. The average time interval to cancer-related death was 28 months. On multivariate analysis, only intraductal carcinoma of the prostate was significantly associated with cancer-specific survival (P = 0.018) and overall survival (P = 0.001), and only the presence of Gleason pattern 5 was significantly associated with prostate-specific antigen progression-free survival (P = 0.026). The presence of intraductal carcinoma of the prostate was the only significant prognostic parameter for cancer-specific survival and overall survival in prostate cancer patients with distant metastasis at presentation. These results may prove useful in planning future treatments.

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Section: Discussionmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Definition Of Intraductal Carcinoma Of the Prostatementioning

confidence: 99%

mentioning

confidence: 99%

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The presence of intraductal carcinoma of the prostate in needle biopsy is a significant prognostic factor for prostate cancer patients with distant metastasis at initial presentation

et al. 2016

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Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology

et al. 2022

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Objectives: This study aims to investigate whether a cribriform pattern on prostate biopsy may be a factor in suspicion of intraductal carcinoma of the prostate after radical prostatectomy.Methods: This retrospective study assessed 100 men who underwent prostatectomy from 2015 to 2019. Participants were grouped as 76 patients with Gleason pattern 4 and 24 patients without this pattern. All 100 participants underwent retrograde radical prostatectomy and limited lymph node dissection. The same pathologist evaluated all specimens. The cribriform pattern was evaluated with haematoxylin and eosin counterstaining, and intraductal carcinoma of the prostate was evaluated with immunohistochemical analysis of cytokeratin 34βE12.Results: Patients with intraductal carcinoma of the prostate on immunohistochemical analysis showed a significant tendency to relapse in the postoperative period, and those with the cribriform pattern on biopsy had a significant recurrence rate. In univariate and multivariate analyses, intraductal carcinoma of the prostate confirmed in biopsy tissue was an independent predictor of biochemical recurrence after prostatectomy. The rate of intraductal carcinoma of the prostate confirmation was 28% of cases with a cribriform pattern in biopsy tissue, which was increased to 62% in prostatectomy tissues. Conclusion:The cribriform pattern in the biopsy tissue may be a predictor for intraductal carcinoma of the prostate.

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Intraductal carcinoma of the prostate (IDC‐P) lowers apparent diffusion coefficient (ADC) values among intermediate risk prostate cancers

Currin

Flood

Krishna

et al. 2018

Magnetic Resonance Imaging

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Background Prostatic intraductal carcinoma (IDC‐P) is an aggressive variant of prostate cancer (PCa) characterized by proliferation of malignant cells within prostatic ducts/acini and nucleomegaly. Purpose/Hypothesis To compare apparent diffusion coefficient (ADC) values and Prostate Imaging and Data Reporting System (PI‐RADS) v. 2 scores in intermediate risk (International Society of Urological Pathology [ISUP] Grade Group [GG] 2 and 3) PCa with/without IDC‐P to determine if IDC‐P alters the MRI appearance of PCa. Study Type Retrospective, case–control. Population Fifteen consecutive men with ISUP GG 2/3 (Gleason score 3+4 = 7 [N = 4], 4+3 = 7 [N = 11]) PCa with IDC‐P diagnosed at radical prostatectomy were compared with: 1) ISUP GG 2/3 PCa without IDC‐P (matched for percentage Gleason pattern 4), and 2) ISUP GG 4 and 5 (Gleason score 8/9) PCa without IDC‐P. Field Strength/Sequence 3T multiparametric MRI. Assessment Two blinded radiologists (R1/R2) measured mean ADC, ADC.ratio (ADC.tumor/ADC.normal peripheral zone) and assigned PI‐RADS v2 scores. Statistical Tests: Chi‐square and analysis of variance (ANOVA). Results There were no differences in age, prostate serum antigen, tumor size, or stage between groups (P = 0.063‐0.912). Tumors with IDC‐P had lower mean ADC and ADC.ratio (0.741 ± 0.152 mm2/sec and 0.44 ± 0.07) compared with ISUP GG 2/3 tumors without IDC‐P (0.888 ± 0.167 mm2/sec and 0.62 ± 0.14), P = 0.012 and <0.001; and did not differ compared with ISUP GG 4/5 tumors (0.705 ± 0.141 mm2/sec and 0.44 ± 0.08), P = 0.509 and 0.868. Tumors with IDC‐P were nearly all PI‐RADS v2 score 5 (14/15) compared with ISUP GG 2/3 tumors without IDC‐P (10/15 R1, 8/15 R2) and GG 4/5 tumors (9/15), (P = 0.040 = 0.092). Agreement in PI‐RADS v2 scoring was moderate (K = 0.68). Data Conclusion ISUP GG 2 and 3 (intermediate risk, Gleason score 7) PCa with IDC‐P have lower ADC compared with tumors without IDC‐P with a similar percentage of Gleason pattern 4 and resemble ISUP GG 4 and 5 high risk tumors on MRI. IDC‐P lowers ADC values among intermediate risk prostate cancers. Level of Evidence: 3 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:279–287.

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Prognostic value of intraductal carcinoma of the prostate in radical prostatectomy specimens

Abstract: IDC-P in RP specimens was an independent risk factor for PFS and CSS and could predict clinical outcomes.

Cited by 142 publications

References 32 publications

The presence of intraductal carcinoma of the prostate in needle biopsy is a significant prognostic factor for prostate cancer patients with distant metastasis at initial presentation

The presence of intraductal carcinoma of the prostate in needle biopsy is a significant prognostic factor for prostate cancer patients with distant metastasis at initial presentation

Cribriform pattern in prostate tissues: Predictor for intraductal carcinoma of the prostate based on biopsy and radical prostatectomy pathology

Intraductal carcinoma of the prostate (IDC‐P) lowers apparent diffusion coefficient (ADC) values among intermediate risk prostate cancers

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