Prognostic value of home heart rate for cardiovascular mortality in the general populationThe Ohasama study

Hozawa, Atsushi; Ohkubo, Takayoshi; Kikuya, Masahiro; Ugajin, Tomohisa; Yamaguchi, Junji; Asayama, Kei; Metoki, Hirohito; Ohmori, Kenji; Hoshi, Hiroyuki; Hashimoto, Junichiro

doi:10.1016/s0895-7061(04)00897-0

Cited by 100 publications

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“…1,2,4 Clinical indications for HBPM Given the fallibility of conventional office BP measurements, HBPM provides clinically useful information on BP level and profile to practising doctors, because it enables a more precise initial diagnosis of hypertension and more accurate titration of antihypertensive drug treatment (Box 7). It also offers useful information on home heart rate 24 and on day-by-day BP variability. 9,10 Therefore, if feasible, it should be used in all treated hypertensive patients.…”

Section: Box 6 Interpretation Of Home Bp Readingsmentioning

confidence: 99%

European Society of Hypertension Practice Guidelines for home blood pressure monitoring

Stergiou²,

et al. 2010

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Section: Box 6 Interpretation Of Home Bp Readingsmentioning

confidence: 99%

European Society of Hypertension Practice Guidelines for home blood pressure monitoring

Stergiou²,

et al. 2010

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“…The ACCOMPLISH study 38 compared benazepril+amlodipine and benazepril+hydrochlorothiazide in high-risk hypertensive patients, and found fewer cardiovascular events with the former combination than with the latter. On the other hand, the GUARD study 39 examined the combination of an angiotensin-converting enzyme inhibitor with a CCB or thiazide diuretic in type II diabetic patients and showed that the thiazide was greater to the CCB with regard to reducing albuminuria.…”

Section: Combined Antihypertensive Therapy With Olmesartan T Ishimitsmentioning

confidence: 99%

Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension

et al. 2009

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To achieve the target blood pressure recommended by the latest guidelines, multiple antihypertensive drugs are needed in most patients. In this study, the efficacy of treatment using an angiotensin II receptor antagonist (ARB) combined with a calcium channel blocker (CCB) or a diuretic was compared from multiple perspectives in patients with hypertension. Twenty-nine patients with essential hypertension, who had failed to achieve their target blood pressure (o130/85 mm Hg for patients o65 years old and o140/90 mm Hg for those X65 years) when treated with the ARB olmesartan at 20 mg day À1 , were additionally given 8-16 mg day À1 of the CCB azelnidipine or 1-2 mg day À1 of trichlormethiazide (a thiazide diuretic) in a randomized crossover manner for 4 months each. At the end of each combination therapy period, blood and urine samples were collected and arterial stiffness was evaluated by measuring the cardio-ankle pulse wave velocity. Compared with monotherapy, the blood pressure was reduced similarly by adding azelnidipine (À12/À10 mm Hg) or trichlormethiazide (À14/À9 mm Hg). The heart rate was decreased with the CCB by 4 b.p.m. (Po0.05), whereas it was unchanged with the thiazide. Serum K, lipids and blood glucose were not significantly changed with either combination, whereas serum uric acid was increased with the thiazide (Po0.01) but was unchanged with azelnidipine. Plasma levels of renin, angiotensin II and aldosterone were also increased with the thiazide period, whereas high-sensitivity C-reactive protein and oxidized low-density lipoprotein were decreased with azelnidipine. In addition, the cardio-ankle vascular index, a parameter of arterial stiffness, was decreased with the azelnidipine period but was unchanged with the thiazide period (Po0.01). It is suggested that the combination of olmesartan and azelnidipine has advantages over the combination of olmesartan and a thiazide with respect to avoiding hyperuricemia, sympathetic activation, renin-angiotensin-aldosterone system stimulation, inflammation, oxidative stress, and increased arterial stiffness in patients with moderate hypertension. These properties may provide cardiovascular protection in addition to the hypotensive effect.

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“…On the other hand, as shown by the Framingham Study (5), there is a positive correlation between clinical pulse rate (PR) measurements and cardiovascular disease mortality after adjustment for BP. Recently, it was reported that PR values recorded at home also predict the risk of cardiovascular disease mortality (6).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Azelnidipine on Home Blood Pressure and Pulse Rate in Patients with Essential Hypertension: Comparison with Amlodipine

Yamagishi

2006

Hypertens Res

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Prognostic value of home heart rate for cardiovascular mortality in the general populationThe Ohasama study

Cited by 100 publications

References 0 publications

European Society of Hypertension Practice Guidelines for home blood pressure monitoring

European Society of Hypertension Practice Guidelines for home blood pressure monitoring

Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension

Efficacy of Azelnidipine on Home Blood Pressure and Pulse Rate in Patients with Essential Hypertension: Comparison with Amlodipine

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