2002
DOI: 10.1177/104063870201400106
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Prognostic Value of Histologic Stage and Proliferative Activity in Canine Malignant Mammary Tumors

Abstract: Abstract. The aim of this study was to investigate the correlation between the histologic invasiveness (histologic stage) and various cell proliferation activity assays (quantity of argyrophil proteins associated with nucleolar organizer regions [AgNORs], mitotic activity, MIB1 [Ki67] immunohistochemical detection) for predicting the biologic behavior of malignant canine mammary tumors. Sixty specimens from malignant canine mammary tumors with no distant metastases (M0) at surgery were selected, and follow-up … Show more

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Cited by 77 publications
(78 citation statements)
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References 25 publications
(37 reference statements)
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“…3,20 In veterinary medicine, MI has been found to be predictive for outcome in canine soft-tissue sarcomas, mammary tumors, as well as cutaneous melanoma. 16,26,29 Last, it has been shown that MI strongly correlates with other parameters used to assess cell proliferation in canine and feline solid tumors, including AgNOR, MIB1, and PCNA. 25 On the basis of the fact that a variety of proliferation indices have been shown to have some prognostic value for canine MCTs, we predicted that MI would be a relatively simple, straightforward measure of proliferation that would provide similar prognostic information.…”
Section: Discussionmentioning
confidence: 99%
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“…3,20 In veterinary medicine, MI has been found to be predictive for outcome in canine soft-tissue sarcomas, mammary tumors, as well as cutaneous melanoma. 16,26,29 Last, it has been shown that MI strongly correlates with other parameters used to assess cell proliferation in canine and feline solid tumors, including AgNOR, MIB1, and PCNA. 25 On the basis of the fact that a variety of proliferation indices have been shown to have some prognostic value for canine MCTs, we predicted that MI would be a relatively simple, straightforward measure of proliferation that would provide similar prognostic information.…”
Section: Discussionmentioning
confidence: 99%
“…It has been demonstrated that MI is a strong predictor of outcome for a variety of human and canine cancers, including thyroid carcinoma, breast carcinoma, sarcomas, among others. 3,16,26,32 Therefore, the purpose of the following study was to determine whether MI is a useful predictor of the biologic behavior of canine MCTs, as this would provide a relatively simple method for assessing MCTs during routine histopathologic examination.…”
mentioning
confidence: 99%
“…PI scores of simple solid carcinomas were higher than the other carcinomas (23). On the contrary, in another study (32), PI scores of simple tubulopapillary carcinomas were found to be higher than those of solid carcinomas, yet with complex carcinomas showing the highest PI values.…”
Section: Discussionmentioning
confidence: 76%
“…Prognostic factors can be defined as specific clinical, pathological, and biological characteristics of individuals and their tumours that permit prediction of clinical outcome and survival of patients without subjecting them to additional and adjuvant therapies after initial surgery (1). The study of prognostic factors is of utmost importance, as it enables prediction of the behaviour and clinical outcome of mammary tumours using individualised therapeutic protocols with appropriate intensity and effectiveness (11,23).…”
Section: Discussionmentioning
confidence: 99%
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