Prognostic Value of Hepatitis B Virus Infection in Very Young Patients With Curatively Resected Breast Cancer: Analyses From an Endemic Area in China

Li, Ning; Zhong, Qing-Qi; Yang, Xin; Wang, Qi-Cai; Zhang, Di-Tian; Zheng, Shaoquan; Yang, Lu; Wei-dong, Wang

doi:10.3389/fonc.2020.01403

Cited by 8 publications

(17 citation statements)

References 38 publications

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“…HBV infection is associated with dysfunction. The association between HBV infection and poor prognosis is keeping demonstrated in a variety of cancers, including nasopharyngeal carcinoma [12], lung cancer [13], breast cancer [14], ovarian cancer [15], diffuse large B cell lymphoma [16][17][18], and pancreatic cancer patients [19]. We speculated HBV infection may have an impact on the prognosis of cervical cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…HBsAg positive patients with cancer, including nasopharyngeal carcinoma [12], lung cancer [13], breast cancer [14], ovarian cancer [15], diffuse large B cell lymphoma [16][17][18], and pancreatic cancer [19] have an inferior OS. Previous studies speculated that it may be linked to certain types of immunological dysfunction [20] HBV reactivation [21], or the presence of Hepatitis B X-interacting protein [22].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, HBV infection has been found to be associated with the prognosis of malignancies. Current or past HBV infection was shown to be an adverse prognostic Ivyspring International Publisher factor in patients with nasopharyngeal carcinoma [12], lung cancer [13], breast cancer [14], ovarian cancer [15], diffuse large B cell lymphoma [16][17][18], and pancreatic cancer [19]. The latent mechanism leading to the unfavorable prognosis in HBV-infected patients with malignancies may be linked to certain types of immunological dysfunction [20], HBV reaction [21] or the presence of Hepatitis B X-interacting protein, which plays an oncogenic role in cancer progression [22].…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of serological markers of hepatitis B virus infection in squamous cell cervical cancer

Wu¹,

Li²,

Li³

et al. 2021

J. Cancer

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Objective: The current study aimed to investigate the prognostic value of serological markers of hepatitis B virus (HBV) infection in squamous cell cervical cancer. Methods: Squamous cell cervical cancer patients treated by concurrent chemoradiotherapy from January 2013 to December 2015 at Yunnan Cancer Hospital were retrospectively reviewed. Results: Of a total of 277 patients, 12 (4.33%), 93 (33.57%), 2 (0.72%), 25 (9.02%), and 36 patients (13.00%) were seropositive for hepatitis B surface antigen (HBsAg), anti-hepatitis B surface antibodies (anti-HBs), hepatitis B envelope antigen (HBeAg), anti-hepatitis B envelope antibodies (anti-HBe), and anti-hepatitis B core antibodies (anti-HBc), respectively. No patients experienced more than mild hepatic adverse events during treatment. The five-year overall survival (OS) rates for patients with anti-HBs positive or negative status were 85.8% and 66.2% (p = 0.039), respectively. No statistically significant difference in the five-year OS rates was observed in HBsAg positive and negative, HBeAg positive and negative, anti-HBe positive and negative, anti-HBc positive and negative patients. The multivariable analysis revealed that anti-HBs positivity was an independent favorable prognostic factor for OS (HR= 0.279; 95%CI: 0.083-0.936; p = 0.039) in patients younger than 50 years. Conclusions: The presence of anti-HBs predicts a superior OS for squamous cell cervical cancer patients aged younger than 50 years.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic value of serological markers of hepatitis B virus infection in squamous cell cervical cancer

Wu¹,

Li²,

Li³

et al. 2021

J. Cancer

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“…It becomes a major heath threaten to females and the public health worldwide, though clinical therapies including surgery, radiotherapy, chemotherapy and targeted therapy for breast cancer have been rapidly developing. Several epidemiological studies had highlighted an increased incidence [3] and bad prognosis [34] of breast cancer in female patients with chronic HBV infection. Therefore, this study investigated the mechanism that lies behind such association by analysing the involvement of HBV-related exosomal miRNA in the changes of gene expression with breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Understand the role of exosomal miRNA in the development of breast cancer in patients with chronic HBV infection

Xie¹,

Chen²,

Lin³

et al. 2021

Preprint

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Background: Female chronic hepatitis B patients has shown a higher incidence of breast cancer with poorer prognosis, compared to the non-infected female patients. A significant difference in miRNAs expression in serum exosomes has been identified between female patients with chronic HBV infection and non-infected female. Whether this difference could contribute to the differential incidence and development of breast cancer in these female patients has not been fully understood.Methods: Information of exosomal expression of miRNAs (expression profiles of GSE33857) were acquired from the Gene Expression Omnibus (GEO) database. Targeted genes of this miRNAs and the differentially expressed genes of breast cancer in GEPIA V2.0 database was used to obtain the differentially expressed genes (DEGs). Four analytic methods were performed, including functional annotation, protein-protein interaction (PPI) network and module construction, the clinical pathologic parameters analysis, alongsides prognosis analysis.Results: In the serum exsomes, expression of miR-1237-3p and miR-363-3p were down-regulated whilst expression of miR-100-5p, miR-125b-5p, miR-1260a, miR-1287-5p, miR-148a-3p, miR-885-5p and miR-99a-5p were up-regulated in female chronic hepatitis B (CHB) patients. 228 up-regulated genes and 641 down-regulated genes were selected as DEGs. The DEGs involved in several biological processes ranging from cellular response to hormone stimulus. According to the main enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway was the pathways in cancer. Our analysis revealed that among the hub genes, CXCL11 was up-regulated and CXCL12, GNG2, LPAR1, GPR17, CXCL1, ADCY5, ADCY3, CX3CL1, S1PR1 were down-regulated. These genes expression levels were verified in UALCAN, Oncomine and HPA database. High expression level of CXCL11 and low expression levels of CXCL12, LPAR1, ADCY3 and CX3CL1 were positively correlated with some clinical pathological parameters that predicted worse prognosis. Kaplan-Meier (K-M) plotter analysis revealed that these genes that showed a low expression level were positively correlated with poor prognosis of breast cancer, and the high expression genes were negatively correlated with poor prognosis of breast cancer.Conclusion: This bioinformatics analysis study explored the mechanisms of chronic HBV related occurrence and development of breast cancer by changing the expression of miRNAs of serum exosomes. It provided novel directions and therapeutic strategy for chronic HBV infection associated occurrence and development of breast cancer in female patients.

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“…A nomogram is a reliable tool to quantify individual risk that incorporates multiple important prognostic factors. 10 , 11 Previously, we established effective prognostic nomogram models for very young patients with breast cancer in a single-center retrospective analysis. 11 However, the sample size is small and small sample size is insufficient to allow us to perform subgroup analysis.…”

Section: Introductionmentioning

confidence: 99%

Construction and Validation of a Nomogram to Predict Overall Survival in Very Young Female Patients with Curatively Resected Breast Cancer

Li¹,

Feng²,

Li³

et al. 2021

CMAR

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Purpose Young age is an independent negative predictor of breast cancer (BC) survival and correlates with the risk of local recurrence and contralateral BC. We aimed to design an effective and comprehensive nomogram to predict prognosis in very young patients with curatively resected BC. Methods Female patients with a diagnosis of BC aged ≤35 years at presentation were identified from the SEER database as a training cohort. The validation cohort consisted of 1002 consecutive women with BC aged ≤35 years that had received curative resection for BC at the Sun Yat-sen University Cancer Center. A nomogram was built based on the identified variables in multivariate Cox proportional hazards model. The performance of the nomogram was quantified using Harrell’s concordance index (C-index) and calibration curves. Results Overall, 10,872 young female patients who underwent surgery for BC were enrolled in the training cohort, while 1002 very young female BC patients were identified as independent validation cohort. Eight covariables (age, race, grade; ER, PR, and HER2 status; T, and N stages) were identified and incorporated to construct a nomogram. The C-index values of the nomogram were 0.727 (95% CI: 0.714–0.740) and 0.722 (95% CI: 0.666–0.778) for OS in the training and validation cohorts, respectively. The calibration curves showed a high degree of agreement between the predicted and actual observed survival rates in both training and validation cohorts. The nomogram displayed good calibration and acceptable discrimination. Based on the TPS of the nomogram model for OS with the X-tile program, patients were divided into 3 risk groups, which were easily discriminated on survival analyses for OS. Conclusion We have successfully constructed an effective nomogram to predict survival outcomes for young female patients with curatively resected BC, which may provide individual survival prediction to benefit prognosis evaluation and individualized therapy.

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Prognostic Value of Hepatitis B Virus Infection in Very Young Patients With Curatively Resected Breast Cancer: Analyses From an Endemic Area in China

Cited by 8 publications

References 38 publications

Prognostic value of serological markers of hepatitis B virus infection in squamous cell cervical cancer

Prognostic value of serological markers of hepatitis B virus infection in squamous cell cervical cancer

Understand the role of exosomal miRNA in the development of breast cancer in patients with chronic HBV infection

Construction and Validation of a Nomogram to Predict Overall Survival in Very Young Female Patients with Curatively Resected Breast Cancer

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