Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study

Leong, Darryl P.; Teo, Koon; Rangarajan, Sumathy; López‐Jaramillo, Patricio; Avezum, Álvaro; Orlandini, Andrés; Serón, Pamela; Ahmed, Suad Hashim; Rosengren, Annika; Kelishadi, Roya; Rahman, Omar; Swaminathan, Sumathi; Iqbal, Romaina; Gupta, Rajeev; Lear, Scott A.; Oğuz, Aytekin; Yusoff, Khalid; Zatońska, Katarzyna; Chifamba, Jephat; Igumbor, Ehimario; Mohan, Viswanathan; Anjana, Ranjit Mohan; Gu, Hongqiu; Li, Wei; Yusuf, Salim

doi:10.1016/s0140-6736(14)62000-6

Cited by 1,367 publications

(1,095 citation statements)

References 30 publications

Supporting

Mentioning

984

Contrasting

Unclassified

Order By: Relevance

“…It has been suggested that handgrip strength is a better marker of frailty than chronological age (Syddall et al 2003), and it predicts all-cause and cause-specific mortality in community-based and patient populations (Fujita et al 1995;Rantanen et al 2000;Sasaki et al 2007;Ling et al 2010;Ortega et al 2012;Leong et al 2015). Moreover, handgrip strength has been found to be associated with disability at older ages (Giampaoli et al 1999;Rantanen et al 1999;Taekema et al 2010), cognitive decline (Alfaro-Acha et al 2006), and hospitalization (Cawthon et al 2009).…”

Section: Sex Differences In Physical Performance Testsmentioning

confidence: 99%

“…Moreover, handgrip strength has been found to be associated with disability at older ages (Giampaoli et al 1999;Rantanen et al 1999;Taekema et al 2010), cognitive decline (Alfaro-Acha et al 2006), and hospitalization (Cawthon et al 2009). While there is compelling evidence that men outperform women on handgrip tests at all ages and across all continents (Bohannon et al 2006;Dodds et al 2014;Leong et al 2015), the magnitude of the male advantage appears to vary across national populations, ethnicities, and age groups. It is remarkable that the grip strength of an 80-year-old Danish man is similar to that of a 45-year-old Danish woman (Frederiksen et al 2006).…”

Section: Sex Differences In Physical Performance Testsmentioning

confidence: 99%

See 1 more Smart Citation

Sex Differences in Health and Survival

Oksuzyan

Gumà

Doblhammer

2018

A Demographic Perspective on Gender, Family and Health in Europe

View full text Add to dashboard Cite

Section: Sex Differences In Physical Performance Testsmentioning

confidence: 99%

Section: Sex Differences In Physical Performance Testsmentioning

confidence: 99%

Sex Differences in Health and Survival

Oksuzyan

Gumà

Doblhammer

2018

A Demographic Perspective on Gender, Family and Health in Europe

View full text Add to dashboard Cite

“…It is thus interesting that the FOXO group of transcription factors appear to be vital in controlling the ageing process across several species and may have evolved to do so [158]. But perhaps one of the most important things about cardiovascular fitness, and strength, is that certainly in humans, increased levels are associated with greatly reduced mortality [159][160][161][162] suggesting a generalised benefit. So, from the point of view of physical activity, as the brain is essential in coordinating movement, the brain's control of physical activity could well be hormetic in and of itself.…”

Section: Enforced Thinkingmentioning

confidence: 99%

The Hormesis of Thinking: A Deeper Quantum Thermodynamic Perspective?

Nunn¹,

Guy²,

Bell³

2017

Int J Neurorehabilitation Eng

View full text Add to dashboard Cite

We are able to read this because of quantum and thermodynamic principles that via an inorganic proton gradient, possibly generated 4.2 billion years ago, gave rise to a system that has an awareness of time and space by using energy to integrate information. Life can be described as a dissipative system driven by an energy gradient that uses information to positively reinforce its self-sustaining structure, which in turn increases its non-linear decisional capacity. Key in the evolution of life has been stress coupled to natural selection, which usually meant an increased demand for energy. As hormesis describes the adaptive response to stress, we propose that hormesis embraces not only the evolution of life, but that of intelligence itself, as natural selection would favour systems that enhances its efficiency. A component of the hormetic response in eukaryotes is the mitochondrion, which itself relies on quantum effects such as tunnelling. This suggests that quantum effects control the stability of individual cells as well as long-lived cellular networks. Hormesis, which can be anti-inflammatory, is therefore key in maintaining the functional stability of complex systems, including the brain. In contrast, a lack of classical hormetic factors, such as physical activity, plant polyphenols, or calorie restriction, will lead to accelerated cognitive decline, which is associated with increased inflammation. However, there may be another previously unidentified factor that could also be considered hormetic, and that is thinking itself. Here we propose that the process of "thinking", and managing complex movement, induces "stress" in the neuronal system and is therefore in itself part of maintaining cognitive health and reserve throughout life. In effect, the right amount of thinking and information processing can beneficially induce adaptation, and this itself could be explainable by quantum thermodynamics.

show abstract

“…The women whose walking pace was brisk or very brisk (≥3.0 mph) had 2.68 fold increased odds of successful survivor compared with the women who walked easy pace (<2.0 mph) as reference [2]. Leong DP et al conducted longitudinal study with 139,691 men and women in 4 years, and found that hazard ratio per 5 kg of reduction in grip strength was 1.16 of cardiovascular mortality, 1.17 of non-cardiovascular mortality, 1.07 of myocardial infarction and 1.09 of stroke [3]. A systematic review and metaanalysis by Cooper et al suggested that the hazard ratio of mortality comparing the lowest quarter with the highest quarter was 1.67 in grip strength, and 2.87 in walking speed [4].…”

Section: Introductionmentioning

confidence: 99%

Fitness Age Score and the Risk of Long-Term Care Insurance Certification—The Kyoto-Kameoka Longitudinal Study

Yoshida¹,

Kimura²,

Yamada³

et al. 2017

OJEpi

View full text Add to dashboard Cite

Long-Term Care Insurance System has been introduced to provide appropriate care for the elderly who needs nursing care in Japan. Physical function is one of most important function for the elderly to live independently. A previous study had established a Fitness Age Score (FAS) based on a theory for biomarker of aging. This study clarified whether the FAS could be used to predict the need for certification of long-term care (CLTC) in independent elderly people. We included 939 independent, community-dwelling-elderly (average age, 74.4 years) whose physical function was measured and for whom the CLTC was tracked for 24 months. The FAS comprised five physical fitness items: Walking time, grip strength, one-leg standing, vertical jump, and functional reach test. Based on the FAS, we calculated the odds ratio (OR) for the CLTC. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) was used for further analysis. We also used the Youden Index (YI), minimum distance method (MD), and two-graph ROC method (TG) to calculate cutoff values (CVs) for screening. We divided subjects into the low and high physical fitness group with CVs. We developed cumulative CLTC curves using the Kaplan-Meier method. Sixteen people could not be tracked for the full 24 months. The measurement of FAS was completed for 798 people, of whom 28 became CLTC. The measurement of FAS was not completed for 125 people, of whom 21 became CLTC. The CLTC OR for people 191with incomplete FAS was 5.553. The AUC was 0.72 (p < 0.001). The CVs for the FAS were −0.29 for YI (sensitivity, 92.9% and specificity, 40.4%), −1.23 for MD (57.1% and 73.4%), and −0.81 for TG (60.7% and 60.9%). The cumulative CLTC curves according to CVs all showed significant differences (p = 0.000 -0.020). In conclusion, the FAS can be used to predict CLTC.

show abstract

Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study

Cited by 1,367 publications

References 30 publications

Sex Differences in Health and Survival

Sex Differences in Health and Survival

The Hormesis of Thinking: A Deeper Quantum Thermodynamic Perspective?

Fitness Age Score and the Risk of Long-Term Care Insurance Certification—The Kyoto-Kameoka Longitudinal Study

Contact Info

Product

Resources

About