Prognostic Value of Geriatric Nutritional Risk Index in Esophageal Carcinoma: A Systematic Review and Meta-Analysis

Zhou, Jianfeng; Fang, Pinhao; Li, Xiaokun; Luan, Siyuan; Xiao, Xin; Gu, Yinmin; Shang, Qi‐Xin; Zhang, Hanlu; Yang, Yu‐Shang; Zeng, Xiaoxi; Yuan, Yong

doi:10.3389/fnut.2022.831283

Cited by 13 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current evidence suggests that the GNRI can be used to predict overall survival in various cancer types. In a meta-analysis of 11 studies involving 1785 patients with esophageal cancer, the pooled results indicated that a lower GNRI adversely affected overall survival with an HR of 1.75 [45]. Furthermore, in a meta-analysis of 11 studies involving 2865 patients with non-small cell lung cancer, a low GNRI was found to be a significant predictor of poor overall survival with an HR of 1.96 [19].…”

Section: Discussionmentioning

confidence: 96%

Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis

Yiu,

Liu,

et al. 2023

Nutrients

View full text Add to dashboard Cite

Head and neck cancer (HNC) is a prevalent malignancy with a poor prognosis, necessitating the identification of prognostic biomarkers to guide management. The geriatric nutritional risk index (GNRI), calculated from serum albumin and body weight, may predict survival in patients with HNC. We performed a systematic review and meta-analysis to clarify this relationship. Databases were searched for studies examining the association between pretreatment GNRI and overall survival in patients with HNC. Ten studies with 2793 patients were included. Meta-analysis demonstrated that low GNRI was associated with significantly worse overall survival compared to high GNRI (hazard ratio [HR]:2.84, 95% CI 2.07–3.91, p < 0.00001). Older age (HR:1.73; 95% CI, 1.35–2.22; p < 0.0001), male sex (HR:1.7; 95% CI, 1.12–2.6; p = 0.01), advanced tumor stage (HR: 2.5; 95% CI, 1.72–3.63; p < 0.00001), and higher T-/N-stage (HR = 1.69 and 1.98, respectively) were also predictive of unfavorable outcomes. The GNRI had the highest HR, suggesting potent predictive ability. Despite limitations, including retrospective design and potential publication bias, our study indicates that low pretreatment GNRI predicts poor overall survival in patients with HNC. The GNRI is an inexpensive, routinely available biomarker that could improve prognostication and guide management decisions. Additional research is warranted to validate these findings.

show abstract

Section: Discussionmentioning

confidence: 96%

Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis

Yiu,

Liu,

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…The GNRI is a simple and objective nutritional status assessment tool that can predict prognosis in patients with malignant (mainly digestive system cancers) and non-malignant diseases (such as heart failure, stroke, and chronic kidney disease) ( 12–19 ). However, no study has reported on the usefulness of GNRI in patients with cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

“…(A,B) The cumulative survival rates were significantly lower in the risk group than in the no-risk group in both patients with compensated and decompensated cirrhosis (p < 0.001 and = 0.013, respectively). The GNRI is a simple and objective nutritional status assessment tool that can predict prognosis in patients with malignant (mainly digestive system cancers) and non-malignant diseases (such as heart failure, stroke, and chronic kidney disease) (12)(13)(14)(15)(16)(17)(18)(19). However, no study has reported on the usefulness of GNRI in patients with cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

“…The GNRI demonstrated superior 1-year prognostic predictability over the global leadership initiative on malnutrition (GLIM) criteria and mini nutritional assessment-short form (MNA-SF) in hospitalized Japanese older adults ( 11 ). Several studies have revealed the usefulness of GNRI in predicting the prognosis of malignancies, including esophageal, gastric, hepatic, pancreatic, and colorectal cancers ( 12–16 ). Reportedly, low GNRI is associated with poor prognosis in non-malignant diseases, including heart failure, stroke, and chronic kidney disease ( 17–19 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low geriatric nutritional risk index predicts poor prognosis in patients with cirrhosis: a retrospective study

Kamioka,

Saeki,

Kinoshita

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

AimMalnutrition, which increases the risk of liver disease-related events and mortality, is a serious complication in cirrhosis. This study aimed to investigate whether the geriatric nutritional risk index (GNRI) could predict the long-term prognosis in patients with cirrhosis.MethodsWe retrospectively evaluated 266 patients with cirrhosis and classified them into two groups based on baseline GNRI scores: risk (≤98, n = 104) and no-risk groups (>98, n = 162). The cumulative survival rates were compared between the two groups in patients with compensated and decompensated cirrhosis, respectively. Cox proportional hazards regression analysis was used to identify significant and independent factors associated with mortality.ResultsThe median observation period was 54.9 (33.6–61.7) months and 65 (24.4%) liver disease-related deaths occurred during the follow-up period. The GNRI scores significantly and inversely correlated with Child-Pugh score (r = −0.579), model for end-stage liver disease score (r = −0.286), and Mac-2 binding protein glycosylation isomer (r = −0.494). Multivariate analysis identified low GNRI as a significant and independent factor associated with mortality [overall cohort: hazard ratio (HR), 0.926; p < 0.001; compensated cirrhosis: HR, 0.947; p = 0.003; decompensated cirrhosis: HR, 0.923; p < 0.001]. The risk group demonstrated significantly lower cumulative survival rates than the no-risk group in overall cohort, and patients with compensated and decompensated cirrhosis (p < 0.001, <0.001, and = 0.013, respectively).ConclusionLow GNRI was associated with poor long-term prognosis in both patients with compensated and decompensated cirrhosis. Therefore, the GNRI is a simple and useful tool for predicting prognosis and modifying the nutritional status in patients with cirrhosis.

show abstract

“…Moreover, there are reports assessing GNRI as a prognostic biomarker, encompassing younger patients with cancer, indicating that GNRI is associated with poor prognosis in various malignancies and can be applied not only in elderly patients but also in young patients. [14][15][16][17][18] However, its prognostic utility for patients with HNC has not been consistently demonstrated. Research has reported an association of low GNRI scores with unfavorable survival outcomes in patients with HNC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta‐analysis

Tsai,

Kuo,

Wang

et al. 2024

Head & Neck

View full text Add to dashboard Cite

We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random‐effects meta‐analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression‐free survival (HR = 1.87, 95% CI = 1.32–2.65, p < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30–4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.

show abstract

Prognostic Value of Geriatric Nutritional Risk Index in Esophageal Carcinoma: A Systematic Review and Meta-Analysis

Cited by 13 publications

References 36 publications

Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis

Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis

Low geriatric nutritional risk index predicts poor prognosis in patients with cirrhosis: a retrospective study

Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta‐analysis

Contact Info

Product

Resources

About