Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-–small cell lung cancer

Woenckhaus, Matthias; Merk, Johannes; Stoehr, Robert; Schaeper, Frank; Gäumann, Andreas; Wiebe, Karsten; Hartmann, Arndt; Hofstaedter, Ferdinand; Dietmaier, Wolfgang

doi:10.1016/j.humpath.2007.05.027

Cited by 71 publications

(69 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CTNNB1 encodes a protein that is a key downstream component of the Wnt signaling pathway (40). CTNNB1 is associated with cadherin-mediated cell-cell adhesion systems and has been suggested as a biomarker for NSCLC prognosis (41). However, to the best of our knowledge, no studies investigating the association between POLR2K/CTNNB1/APP and pneumonia have been performed.…”

Section: Discussionmentioning

confidence: 99%

Identification of miRNA biomarkers of pneumonia using RNA-sequencing and bioinformatics analysis

Huang¹,

Cong²,

Zhai³

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Pneumonia is a lower respiratory tract infection that causes dramatic mortality worldwide. The present study aimed to investigate the pathogenesis of pneumonia and identify microRNA (miRNA) biomarkers as candidates for targeted therapy. RNA from the peripheral blood plasma of participants with pneumonia (severe, n=9; non-severe, n=9) and controls (n=9) was isolated and paired-end sequencing was performed on an Illumina HiSeq4000 system. Following the processing of raw reads, the sequences were aligned against the Genome Reference Consortium human genome assembly 38 reference genome using Bowtie2 software. Reads per kilobase of transcript per million mapped read values were obtained and the limma software package was used to identify differentially expressed miRNAs (DE-miRs). Then, DE-miR targets were predicted and subjected to enrichment analysis. In addition, a protein-protein interaction (PPI) network of the predicted targets was constructed. This analysis identified 11 key DE-miRs in pneumonia samples, including 6 upregulated miRNAs (including hsa-miR-34a and hsa-miR-455) and 5 downregulated miRNAs (including hsa-let-7f-1). All DE-miRs kept their upregulation/downregulation pattern in the control, non-severe pneumonia and severe pneumonia samples. Predicted target genes of DE-miRs in the subjects with non-severe pneumonia vs. the control and the subjects with severe pneumonia vs. the non-severe pneumonia group were markedly enriched in the adherens junction and Wnt signaling pathways. KALRN, Ras homolog family member A (RHOA), β-catenin (CTNNB1), RNA polymerase II subunit K (POLR2K) and amyloid precursor protein (APP) were determined to encode crucial proteins in the PPI network constructed. KALRN was predicted to be a target of hsa-mir-200b, while RHOA, CTNNB1, POLR2K and APP were predicted targets of hsa-let-7f-1. The results of the present study demonstrated that hsa-let-7f-1 may serve a role in the development of cancer and the Notch signaling pathway. Conversely, hsa-miR-455 may be an inhibitor of pneumonia pathogenesis. Furthermore, hsa-miR-200b might promote pneumonia via targeting KALRN.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of miRNA biomarkers of pneumonia using RNA-sequencing and bioinformatics analysis

Huang¹,

Cong²,

Zhai³

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…The dysregulation of the Wnt/b-catenin pathway has been observed in various forms of cancer. It has been recently shown that overexpression of WNTs and their downstream effectors are associated with poor prognosis in patients with non-small cell lung carcinoma (NSCLC) and involved in metastasis of lung cancer, the most common cause of cancer-related mortality worldwide (6)(7)(8)(9). The mechanisms through which Wnt/b-catenin regulates EMT and tumor metastasis, however, are currently not fully understood.…”

Section: Introductionmentioning

confidence: 99%

miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM

et al. 2014

View full text Add to dashboard Cite

The nodal regulatory properties of microRNAs (miRNA) in metastatic cancer may offer new targets for therapeutic control. Here, we report that upregulation of miR-483-5p is correlated with the progression of human lung adenocarcinoma. miR-483-5p promotes the epithelial-mesenchymal transition (EMT) accompanied by invasive and metastatic properties of lung adenocarcinoma. Mechanistically, miR-483-5p is activated by the WNT/b-catenin signaling pathway and exerts its prometastatic function by directly targeting the Rho GDP dissociation inhibitor alpha (RhoGDI1) and activated leukocyte cell adhesion molecule (ALCAM), two putative metastasis suppressors. Furthermore, we found that downregulation of RhoGDI1 enhances expression of Snail, thereby promoting EMT. Importantly, miR-483-5p levels are positively correlated with b-catenin expression, but are negatively correlated with the levels of RhoGDI1 and ALCAM in human lung adenocarcinoma. Our findings reveal that miR-483-5p is a critical b-catenin-activated prometastatic miRNA and a negative regulator of the metastasis suppressors RhoGDI1 and ALCAM. Cancer Res; 74(11); 3031-42. Ó2014 AACR.

show abstract

“…The forced swimming test (Woenckhaus et al., 2008) was used to evaluate the Levels of BLA. All mice were forced to swim with a load (5% body weight) attached to the tail for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Antifatigue and antiaging effects of Chinese rice wine in mice

Zhao

Wang

Zhao

et al. 2018

Food Science & Nutrition

View full text Add to dashboard Cite

Chinese rice wine (CRW) is widely known for keeping good health and commonly used in the traditional Chinese medicine prescription guiding drug. This study assesses the effects of CRW on antifatigue and antiaging activities in mice models. Mice were randomly divided into four groups performing with 0.25 ml of distilled water, 0.15, 0.25, and 0.4 ml of CRW for 15 consecutive days. The CRW could obviously increase the content of liver glycogen (LG) and decrease the levels of blood lactic acid (BLA)and blood urea nitrogen (BUN) to improve antifatigue ability. In antiaging assay, CRW significantly increased the activity of SOD in liver, the activities of GSH‐Px and CAT in brain cortex, body quality, thymus index, and spleen index, and decreased liver MDA levels, liver total cholesterol content, and AChE levels in hippocampus. The CRW has potent antifatigue ability and could minimize the occurrence of age‐associated disorders.

show abstract

Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-–small cell lung cancer

Cited by 71 publications

References 58 publications

Identification of miRNA biomarkers of pneumonia using RNA-sequencing and bioinformatics analysis

Identification of miRNA biomarkers of pneumonia using RNA-sequencing and bioinformatics analysis

miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM

Antifatigue and antiaging effects of Chinese rice wine in mice

Contact Info

Product

Resources

About