Prognostic value of estrogen receptors mRNA expression in non-small cell lung cancer: A systematic review and meta-analysis

Li, Wentao; Tse, Lap Ah; Wang, Feng

doi:10.1016/j.steroids.2015.09.005

Cited by 24 publications

(13 citation statements)

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“…Moreover, there are also some reports claiming that ESR1 could suppress the inflammatory process mediated by interleukin-6 and reduce hepatic injury and the compensatory proliferation of hepatocytes [16]. Recent research has shown that cancers such as non-small cell lung cancer (NSCLC) also have very low-expression level of ESR1 [17]. FOXO, which has four members including FOXO1, is one of the 19 kinds of forkhead box transcription factors and is mainly express in mammals [18, 19].…”

Section: Discussionmentioning

confidence: 99%

Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis

et al. 2017

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BackgroundHepatocellular carcinoma (HCC) is the most common liver malignancy worldwide. However, present studies of its multiple gene interaction and cellular pathways still could not explain the initiation and development of HCC perfectly. To find the key genes and miRNAs as well as their potential molecular mechanisms in HCC, microarray data GSE22058, GSE25097, and GSE57958 were analyzed.MethodsThe microarray datasets GSE22058, GSE25097, and GSE57958, including mRNA and miRNA profiles, were downloaded from the GEO database and were analyzed using GEO2R. Functional and pathway enrichment analyses were performed using the DAVID database, and the protein–protein interaction (PPI) network was constructed using the Cytoscape software. Finally, miRDB was applied to predict the targets of the differentially expressed miRNAs (DEMs).ResultsA total of 115 differentially expressed genes (DEGs) were found in HCC, including 52 up-regulated genes and 63 down-regulated genes. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses from DAVID showed that up-regulated genes were significantly enriched in chromosome segregation and cell division, while the down-regulated genes were mainly involved in complement activation, protein activation cascades, carboxylic acid metabolic processes, oxoacid metabolic processes, and the immune response. From the PPI network, the 18 nodes with the highest degree were screened as hub genes. Among them, ESR1 was found to have close interactions with FOXO1, CXCL12, and GNAO1. In addition, a total of 64 DEMs were identified, which included 58 up-regulated miRNAs and 6 down-regulated miRNAs. ESR1 was potentially targeted by five miRNAs, including hsa-mir-18a and hsa-mir-221.ConclusionsThe roles of DEMs like hsa-mir-221 in HCC through interactions with DEGs such as ESR1 and CXCL12 may provide new clues for the diagnosis and treatment of HCC patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s12957-017-1127-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis

et al. 2017

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“…Most reports found that the nuclear ERβ was predictive of a better prognosis, and the cytoplasmic ERβ was associated with a poor prognosis [ 47 , 48 ]. Nonetheless, opposing results have also been reported [ 54 , 60 , 62 , 63 , 65 , 66 ]. Co-expression of the cytoplasmic ERβ and the nuclear ERβ that had been reported correlated with a poor survival rate when compared to those without co-expression [ 67 ].…”

Section: Estrogen Receptor In Lung Cancermentioning

confidence: 98%

Estrogen, Estrogen Receptor and Lung Cancer

Hsu

Chu

Kao

2017

IJMS

159

124

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Estrogen has been postulated as a contributor for lung cancer development and progression. We reviewed the current knowledge about the expression and prognostic implications of the estrogen receptors (ER) in lung cancer, the effect and signaling pathway of estrogen on lung cancer, the hormone replacement therapy and lung cancer risk and survival, the mechanistic relationship between the ER and the epidermal growth factor receptor (EGFR), and the relevant clinical trials combining the ER antagonist and the EGFR antagonist, to investigate the role of estrogen in lung cancer. Estrogen and its receptor have the potential to become a prognosticator and a therapeutic target in lung cancer. On the other hand, tobacco smoking aggravates the effect of estrogen and endocrine disruptive chemicals from the environment targeting ER may well contribute to the lung carcinogenesis. They have gradually become important issues in the course of preventive medicine.

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“…Studies have shown that both estrogen receptors of ERα and ERβ were expressed in lung tumor tissue [19], while ERβ is the dominant ER isoform in NSCLC, expressed in about 90% of all NSCLC cases, ERα isoform expression is relatively low and expressed as variant fragment protein forms, not full-length protein, which can only be recognized by C-terminal antibody [7,20,21]. Several studies, including systematic meta-analyses, have shown that estrogen receptor expression both in mRNA and protein levels is closely related to the survival prognosis of NSCLC [11,22]. However, no study yet available evaluate the possible influence of ER expression on treatment outcomes of NSCLC, especially on the effect of ACT after resection.…”

Section: Discussionmentioning

confidence: 99%

“…ERα was elevated in NSCLC but was not predictive of survival. It is expressed not as an intact fully functional protein but as variant protein that only can be recognized by the C-terminal antibody [7,10,11]. These studies have provided robust evidence on the links between ER signaling and pathophysiological features of NSCLC, indicated the prognostic effect of ERs expression on NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of ESR2 expression on adjuvant chemotherapy in completely resected NSCLC

Qian

2020

PLoS ONE

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Background Prognostic biomarker, which can inform the treatment outcome of adjuvant chemotherapy (ACT) after complete resection of early-stage non-small cell lung cancer (NSCLC), is urgently needed for the personalized treatment of these patients. Patients and methods The prognostic value of gene expression of the estrogen receptor (ER) on the effect of ACT in completely resected NSCLC was investigated in the present study. Two independent datasets from Gene Expression Omnibus (GEO) with a total of 309 patients were included in this study. The prognostic value of ER gene expression on ACT’s efficacy was evaluated by survival analysis and Cox hazards models. Results We found a consistent and significant prognostic value of ERβ (ESR2) expression for ACT’s efficacy in completely resected NSCLC in both of the two independent cohorts. After multivariate adjustment, a significant survival benefit of ACT was observed in patients with low expression of ESR2, with a hazard ratio (HR) of 0.19 (95%CI 0.05–0.82, p = 0.026) in the discovery cohort and an HR of 0.27 (95%CI 0.10–0.76, p = 0.012) in the validation group. No significant benefit of ACT in the subgroup of patients with high expression of ESR2 was observed, with an HR of 0.80 (95%CI 0.31–2.09, p = 0.644) in the discovery cohort and an HR of 1.05 (95%CI 0.48–2.29, p = 0.896) in the validation group. Conclusion A significant survival benefit from ACT was observed in patients with low ESR2 expression. No significant survival benefit was observed in patients with high ESR2 expression. Detection of ESR2 expression in NSCLC may help personalize its treatment after complete resection.

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Prognostic value of estrogen receptors mRNA expression in non-small cell lung cancer: A systematic review and meta-analysis

Cited by 24 publications

References 24 publications

Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis

Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis

Estrogen, Estrogen Receptor and Lung Cancer

Prognostic value of ESR2 expression on adjuvant chemotherapy in completely resected NSCLC

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