Prognostic value of ERCC1, RRM1, BRCA1 and SETDB1 in early stage of non-small cell lung cancer

Lafuente-Sanchis, Aranzazu; Zúñiga, Ángel; Galbis, Jose M.; Cremades, Antonio; Estors, Miriam; Martínez-Hernández, Néstor J.; Carretero, Julián

doi:10.1007/s12094-015-1440-6

Cited by 31 publications

(37 citation statements)

References 24 publications

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“…For example, we found that patients who showed higher expression of both SETDB1 mRNA and protein had shorter overall survival times than patients who showed low SETDB1 expression (Figs and ). This result helps to confirm trends that have been observed in several other types of human cancer . Taken together, our findings indicate that colon adenocarcinoma patients with elevated SETDB1 levels have a higher risk of recurrence and a poorer prognosis than patients with normal SETDB1 levels.…”

Section: Discussionsupporting

confidence: 89%

“…Previous studies have revealed that SETDB1 plays an oncogenic role in the promotion of some cancers (). First, recent publications have indicated that (i) higher levels of SETDB1 expression and amplification are associated with shorter survival times in patients suffering from non–small‐cell lung cancer ; and (ii) SETDB1 accelerates tumourigenesis by regulating the WNT signaling pathway . Moreover, SETDB1 has also been found to cooperate with the SMAD2/3 pathway in the suppression of lung cancer metastasis; and restoring expression of SETDB1 suppressed filopodia formation, migration, and invasive behavior in lung cancer cells .…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, a previous investigation found that the expression of SETDB1 was significantly increased in early‐stage lung cancer patients and in patients who suffered tumor recurrence. SETDB1 has also been found to activate the WNT pathway and reduce P53 expression, which may enhance the growth of non–small‐cell lung cancers . However, little is known about the role of SETDB1 in CRC.…”

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confidence: 99%

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Significance of histone methyltransferase SETDB1 expression in colon adenocarcinoma

Huang

Chang

et al. 2017

APMIS

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This study investigated the clinical implications of SETDB1 (also known as KMT1E) in human colon adenocarcinoma. Expression levels of SETDB1 proteins were analyzed by immunohistochemistry staining, and tissue microarrays were used to examine expression profiles in human patients. Our results revealed that SETDB1 protein expression was significantly higher in tumor tissue than in normal tissue for the breast, colon, liver, and lung (p < 0.05). Moreover, an analysis with SurvExpress software suggested that elevated expression of SETDB1 mRNA was significantly associated with the overall survival of colon adenocarcinoma patients (p < 0.05); and additional analysis involving 90 paired samples of colon adenocarcinoma tissue and normal tissue revealed that SETDB1 protein expression was 82% higher in cancerous cells (p < 0.001). High SETDB1 expression was also found to be significantly correlated with histological grade (p = 0.005), TNM stage (p = 0.003), T-class/primary tumor (p = 0.001), and N-class/regional lymph nodes (p = 0.017); and Kaplan-Meier survival curves indicated that SETDB1 protein expression was significantly associated with poor survival. Finally, univariate analysis demonstrated that SETDB1 protein expression was related to TNM stage (p = 0.004) and SETDB1 score (p = 0.001), whereas multivariate analysis showed that the influence of SETDB1 on overall colon adenocarcinoma survival was independent from other risk factors. Taken together, our results suggest that the SETDB1 protein could serve as a clinical prognostic indicator for colon adenocarcinoma.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Significance of histone methyltransferase SETDB1 expression in colon adenocarcinoma

Huang

Chang

et al. 2017

APMIS

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“…Mutations in this gene are responsible for approximately 40% of inherited breast cancers and 80% of inherited ovarian cancers [31]. Mounting evidence shows that the expression of BRCA1 is associated with the natural prognosis and treatment prognosis in lung cancer [32,33]. High levels of BRCA1 and SETDB1 expression have been significantly associated with shorter disease-free survival in stage I NSCLC patients [33].…”

Section: Discussionmentioning

confidence: 99%

“…Mounting evidence shows that the expression of BRCA1 is associated with the natural prognosis and treatment prognosis in lung cancer [32,33]. High levels of BRCA1 and SETDB1 expression have been significantly associated with shorter disease-free survival in stage I NSCLC patients [33]. NSCLC patients lacking the expression of ERCC1 and BRCA1 benefit more from adjuvant cisplatin-based chemotherapy compared with patients that expressed either ERCC1 or BRCA1 [32].…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Transcription Factors Associated with Lung Squamous Cell Carcinoma

Zhang

Chen²,

Wei³

et al. 2017

Med Sci Monit

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BackgroundLung squamous cell carcinoma (lung SCC) is a common type of lung cancer, but its mechanism of pathogenesis is unclear. The aim of this study was to identify key transcription factors in lung SCC and elucidate its mechanism.Material/MethodsSix published microarray datasets of lung SCC were downloaded from Gene Expression Omnibus (GEO) for integrated bioinformatics analysis. Significance analysis of microarrays was used to identify differentially expressed genes (DEGs) between lung SCC and normal controls. The biological functions and signaling pathways of DEGs were mapped in the Gene Otology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, respectively. A transcription factor gene regulatory network was used to obtain insights into the functions of DEGs.ResultsA total of 1,011 genes, including 539 upregulated genes and 462 downregulated genes, were filtered as DEGs between lung SCC and normal controls. DEGs were significantly enriched in cell cycle, DNA replication, p53 signaling pathway, pathways in cancer, adherens junction, and cell adhesion molecules signaling pathways. There were 57 transcription factors identified, which were used to construct a regulatory network. The network consisted of 736 interactions between 49 transcription factors and 486 DEGs. NFIC, BRCA1, and NFATC2 were the top 3 transcription factors that had the highest connectivity with DEGs and that regulated 83, 82, and 75 DEGs in the network, respectively.ConclusionsNFIC, BRCA1, and NFATC2 might be the key transcription factors in the development of lung SCC by regulating the genes involved in cell cycle and DNA replication pathways.

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Surveillance of Retroelement Expression and Nucleic‐Acid Immunity by Histone Methyltransferase SETDB1

Kang

2018

BioEssays

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In human cancers, histone methyltransferase SETDB1 (SET domain, bifurcated 1) is frequently overexpressed but its significance in carcinogenesis remains elusive. A recent study shows that SETDB1 downregulation induces de-repression of retroelements and innate immunity in cancer cells. The possibility of SETDB1 functioning as a surveillant of retroelement expression is discussed in this study: the cytoplasmic presence of retroelement-derived nucleic acids (RdNAs) drives SETDB1 into the nucleus by the RNA-interference route, rendering the corresponding retroelement transcriptionally inert. These RdNAs could, therefore, be signals of genome instability sent out for SETDB1 present in the cytoplasm to maintain genome integrity.

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Prognostic value of ERCC1, RRM1, BRCA1 and SETDB1 in early stage of non-small cell lung cancer

Cited by 31 publications

References 24 publications

Significance of histone methyltransferase SETDB1 expression in colon adenocarcinoma

Significance of histone methyltransferase SETDB1 expression in colon adenocarcinoma

Identification of Key Transcription Factors Associated with Lung Squamous Cell Carcinoma

Surveillance of Retroelement Expression and Nucleic‐Acid Immunity by Histone Methyltransferase SETDB1

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