Prognostic value of different serum biomarkers for left ventricular remodelling after ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Urbano-Moral, José Ángel; López-Haldón, José E.; Fernández, Mónica Alvarez; Mancha, Fernando; Sánchez, Ángel; Rodríguez-Puras, María J.; Villa, Manuel; F, López-Pardo; Llera, Luis Díaz de la; Valle, Juan Ignacio Soto; Martı́nez, Ángel

doi:10.1136/heartjnl-2012-301636

Cited by 40 publications

(32 citation statements)

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“…Multiple logistic regression analysis showed, however, that the concentrations of CK-MB, cTnI, NT-proBNP and CRP were not independent predictors of LVR. Although acute-phase cTnI and CRP concentrations have been reported to predict LVR [25], cTnI release during STEMI was reported to be poorly predictive of post-MI LV dysfunction [26]. In contrast, serial measurements of B-type natriuretic peptide, cTnI, and CRP were found to be predictive of LVR after acute MI [27].…”

Section: Discussionmentioning

confidence: 99%

Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction

et al. 2015

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Objectives: MicroRNA (miR)-146a and miR-21 have been reported to participate in inflammatory reactions and fibrosis. Excessive inflammation and cardiac fibrosis may play important roles in the development of left ventricular remodeling (LVR). This study assessed whether miR-146a, miR-21 and other biomarkers could predict LVR after myocardial infarction (MI). Methods: Circulating miR-146a, miR-21 and other biomarker levels were measured in 198 patients with acute MI 5 days after primary percutaneous coronary intervention (PCI). All patients were assessed by transthoracic echocardiography on day 5 and 1 year after primary PCI. Results: Concentrations of circulating miR-146a, miR-21, C-reactive protein, creatine kinase MB type and troponin I, as well as estimated glomerular filtration rate (eGFR) and left ventricular ejection fraction (LVEF), were significantly higher in patients with than in those without LVR (p < 0.05). Multivariate logistic regression analysis showed that circulating miR-146a (odds ratio, OR = 2.127, p < 0.0001), miR-21 (OR = 1.119, p < 0.0001), eGFR (OR = 0.939, p = 0.0137) and LVEF (OR = 0.802, p = 0.0048) were independent predictors of LVR development. The area under the curve for the combination of miR-146a and miR-21 was significantly higher than for either alone. Conclusion: Circulating miR-146a and miR-21 may be novel biomarkers predictive of LVR after acute MI. Their combination may better predict LVR than either alone.

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Section: Discussionmentioning

confidence: 99%

Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction

et al. 2015

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“…Previous studies highlighted different risk markers for the development of LVR after STEMI. Hs-cTnT, a well-established marker for the extent of myocardial and microvascular damage [12], was shown to be a strong predictor of LVR [10,21].…”

Section: Post-infarction Adverse Remodellingmentioning

confidence: 99%

Heart rate and left ventricular adverse remodelling after ST-elevation myocardial infarction

Reindl

Reinstadler

Feistritzer

et al. 2016

International Journal of Cardiology

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“…Длительная ДАТТ у пациентов с анамнезом пере-несенного ИМ, отличающихся большей активацией тромбоцитов [28] и неспецифической воспалитель-ной реакцией [29,30], чем у стабильных пациентов, имеет больше аргументов, снижая вероятность ише-мических событий не только в коронарном бассейне. Так, результаты мета-анализа подчеркнули интерес-ный факт -продленная ДАТТ у пациентов с ИМ в анамнезе снижает вероятность развития ишемиче-ского инсульта на 19% (ОР=0,81; 95% ДИ 0,68-0,97; р=0,02).…”

Section: целесообразность использования длительной датт показана и с unclassified

Timeline for the Double Antiplatelet Therapy. Facts and Suggestions

Барбараш¹,

Кашталап²

2016

Russ J Cardiol

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Ключевые слова: двойная антитромбоцитарная терапия, продолжитель-ность, ишемические события, кровотечения, аспирин, тиенопиридины.1 ФГбНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний, Кемерово; 2 ГбОУ ВПО Кемеровская государствен-ная медицинская академия Минздрава России, Кемерово, Россия. барбараш О. Л.* -д. м.н., профессор, директор, зав. кафедрой кардиологии и сердечно-сосудистой хирургии, Кашталап В. В. -д. м.н., зав. лабораторией патофизиологии мультифокального атеросклероза, доцент кафедры кардио-логии и сердечно-сосудистой хирургии.*Автор, ответственный за переписку (Corresponding author): olb61@mail.ru АСК -ацетилсалициловая кислота, дАТТ -двойная антитромбоцитарная терапия, дИ -доверительный интервал, ИбС -ишемическая болезнь серд ца, ИМ -инфаркт миокарда, ККТ -комбинированная конечная точка, ОКС -острый коронарный синдром, ОР -относительный риск, ОШ -отно-шение шансов, ССС -сердечно-сосудистые события, ТИА -транзиторная ишемическая атака, ЧКВ -чрескожные коронарные вмешательства, BMs -стенты без лекарственного покрытия, dEs -стенты с лекарственным покры-тием.Рукопись получена 18.11.2015 Рецензия получена 20.11.2015 Принята к публикации 27.11.2015 TIMELINE FOR THE DOUbLE ANTIPLATELET THERAPY. FACTS AND SUGGESTIONSThe review article provides with recent data on the crucial cardiology problemsduration of double antiplatelet therapy (dAPT) in patients with different types of ischemic heart disease. The analysis is provided of actual clinical guidelines on this issue, the results of recent clinical trials are highlighted, as of metaanalyses. Based on the results of international trials, the necessity postulated of thorough assessment of risk and safety for either prolongation or shortening of dAPT, and some possible indications provided for these changes in 12-month dAPT. Russ

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Prognostic value of different serum biomarkers for left ventricular remodelling after ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Abstract: Myocardial necrosis, as measured by released TnT, and inflammation state evident due to circulating levels of CRP are factors that may play a major role in the development of LVR following STEMI treated with primary PCI.

Cited by 40 publications

References 53 publications

Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction

Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction

Heart rate and left ventricular adverse remodelling after ST-elevation myocardial infarction

Timeline for the Double Antiplatelet Therapy. Facts and Suggestions

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