Prognostic value of cytokines and their soluble receptors and HLA-DR alleles in african patients with severe malaria.

Dieye, A; Angel, G; Ndiaye, Mouhamadou; Thiam, Alassane; Ndiaye, Rokhaya; Seignot, P; Roussilhon, Christian; Sarthou, Jean Louis

doi:10.1016/s1383-5769(98)80250-x

Cited by 3 publications

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“…Our results are consistent with those in the literature who see a risk of occurrence of a PR 2-3 times higher in the offspring of a patient with the disease, however, although it is not a genetically transmitted disease [10,11]. In Senegal, a case of PR in four part of an inflammatory arthritis family [12]. Electrocardiographic abnormalities during the observed RA are different.…”

Section: Discussionsupporting

confidence: 91%

Importance of Electrocardiogram for Detection of Preclinical Abnormalities in Patients with Rheumatoid Arthritis without Cardiovascular Events

Dodo-Siddo¹,

Sarr²,

Ndiaye³

et al. 2015

J Arthritis

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Arthritis Dodo-Siddo et al., J Arthritis 2015, 4:2 http://dx.doi.org/10.4172/2167 Keywords: Electrocardiogram; Rheumatoid arthritis; Myocardial hyperexcitability IntroductionBesides articular symptoms, rheumatoid arthritis (RA) can be associated with extra-articular features. Among those extra-articular features, cardiovascular diseases are common, including pericarditis, cardiomyopathy, cardiac amyloidosis, coronary vasculitis, arrhythmia, valve diseases, congestive heart failure, and ischemic heart disease [1]. It is a chronic inflammatory disease affecting 1% of the population [2,3]. Apart from the extra-articular manifestations, it is associated with an increased risk of cardiovascular events [4]. The mechanisms that explain the rise in cardiovascular morbidity and mortality have not yet been elucidated. However, it seems that traditional cardiovascular risk factors contribute but elements specific to RA, including the existence of a chronic inflammation of the endothelium exposed to accelerated atherosclerosis [5]. Mark cardiovascular abnormalities based on the ECG, which is a non-invasive, relatively acceptable cost. It is in this light that we conducted this study whose objective was to investigate electrocardiographic abnormalities in rheumatoid arthritis, in a population of Senegalese patients, asymptomatic cardiovascular plan. Patients and MethodsThis is a descriptive cross-sectional study, including outpatients in the internal medicine department of Hospital-University Centre Aristide Le Dantec in Dakar, Senegal, with a diagnosis of rheumatoid Our purpose of this study was to investigate the electrocardiographic abnormalities in a population of Senegalese patients with rheumatoid arthritis without clinically evident cardiovascular manifestations. Patients and methods:The study was performed as a cross-sectional study, which included prospectively 73 patients of both sexes aged at least 18 years in the internal medicine department of University Hospital Center Aristide Le Dantec in Dakar, Senegal, fulfilling the criteria for definite or classical rheumatoid arthritis according to the criteria of the American Rheumatism Association. It focused on a sample of following clinical examination, we conducted laboratory tests (CRP, fibrinogen, ESR, Rheumatoid factors: Latex and Waaler Rose, Anti-CCP, antinuclear factors and antibodies anti-ENA), a standard ECG. Data were analyzed using a descriptive study of the different variables with the calculation of proportions for categorical variables, and the positional parameters and dispersion for quantitative variables.Results: All patients had normal ECG and no cardiac symptoms or dyspnoea on effort. The study included 73 patients (68 females and 5males) with rheumatoid arthritis without obvious cardiac events meet the criteria of definition of the ACR 1987. The mean age was 44.17 ± 14.43 years with extremes of 18 and 75 years. The mean duration of RA was 5.93 ± 4.78 years. The concept of family inflammatory arthritis was reported in 35.60% of cases and almost on...

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Section: Discussionsupporting

confidence: 91%

Importance of Electrocardiogram for Detection of Preclinical Abnormalities in Patients with Rheumatoid Arthritis without Cardiovascular Events

Dodo-Siddo¹,

Sarr²,

Ndiaye³

et al. 2015

J Arthritis

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“…Our results are in agreement with those of several studies [18,19] who pointed out that the risk of occurrence of RA is two to three times higher in the offspring of a patient with the disease although it however, is not a genetically transmitted disease. In Senegal, a case of PR in four part of an inflammatory arthritis family [20]. different.…”

Section: Discussionmentioning

confidence: 99%

Research of Electrocardiographic and Echocardiographic Abnormalities in Rheumatoid Arthritis without Clinical Cardiovascular Events

Dodo¹

2015

J Arthritis

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Introduction: IT has been known for many years that the heart may be involved in rheumatoid arthritis. The aim of this study is to investigate the electrocardiographic and echocardiographic abnormalities in a population of Senegalese patients with rheumatoid arthritis without clinical cardiovascular disease. Patients and method: Seventy three consecutive patients between the age of 18 and 75 years admitted to the internal medicine department of University Hospital Center Aristide Le Dantec in Dakar, Senegal, with a diagnosis of rheumatoid arthritis without clinically evident cardiovascular disease. Each patient had a cardiological assessment which included a history and examination with ECG, echocardiography standard. We conducted laboratory tests (CRP, fibrinogen, ESR, Rheumatoid factors: Latex and Waaler Rose, Anti-CCP, antinuclear factors and anti-ENA antibodies). Data were analyzed using a descriptive study of the different variables with the calculation of proportions for categorical variables, and the positional parameters and dispersion for quantitative variables. Results: Sixty eight female and five patients with rheumatoid arthritis without obvious cardiac events meet the criteria of definition of the ACR 1987 were studied. The mean age was 44.17 ± 14.43 years with extremes of 18 and 75 years. The mean duration of RA was 5.93 ± 4.78 years. The concept of family inflammatory arthritis was reported in 35.60% of cases and almost one in six patients had at least a factor of cardiovascular risk (16.96%). Electrocardiographic findings were dominated by a left axis deviation in 16.44% of patients and 34 patients (46.57%) had left ventricular hypertrophy. Myocardial hyperexcitability was present in 8 patients (11.19%), including 6 premature ventricular found in patients with active RA. Twenty-six patients (35.61%) showed signs consistent with ischemia and / or myocardial injury. The echocardiography abnormalities were dominated by diastolic LV dysfunction (42.46%), increased left ventricular mass in 35.61%. Valvular leaks grades variables been highlighted regarding all orifices but rarely significant. Conclusion: Electrocardiogram and echocardiogram are a sensitive and reliable diagnostic aid for the detection of cardiac lesions in rheumatoid arthritis without clinical cardiovascular events.

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“…Toute fois un lien génétique est établi chez les caucasiens entre la PR et HLA DR1, DR4 et DR10 (Bardin et al, 2015). Une étude sénégalaise a trouvé un lien entre PR et HLA DR10 (Dieye et al, 1997). Une autre étude a trouvé un lien avec PR et HLA-DR1 en Afrique de l'Ouest (Roux, 2002), correspondant à notre zone géographique.…”

Section: Discussionunclassified

Polyarthrite Rhumatoïde en Consultation Rhumatologique à Maradi, Niger

Salissou

Condé

Adamou

et al. 2019

ESJ

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Rheumatoid arthritis (RA) is the most common auto-immune disease. Rarely described in Niger, we reported its epidemiological, clinical, paraclinical, therapeutic, and evolutionary aspects in hospitals environments. In order to analyze these aspects in detail, a prospective study has been realized over a period of one (1) year in the Rheumatology Department of the Regional Hospital Center of Maradi. We have included all RA cases in accordance with the ACR/EULAR classification criteria of 2010. The data was entered and analyzed on SPSS 20.0 software. After collecting and studying 32 AR observations from among 846 rheumatologic consultations, the results have demonstrated different points: the average patient's age is 38,9 years, the delay for the diagnosis was 6 years, and in some cases extraarticular manifestations have been observed. The results show that the inflammatory syndrome was constant and that the treatment remains classic with non-pharmacologic means, analgesics, NSAID (non-steroidal antiinflammatory agent), infiltrations and DMARDs (disease-modifying anti-rheumatic drug). The evolution is positive in all the cases. Thanks to this study it is possible to affirm that rheumatoid arthritis is a reality in Niger and it has been better described. The diagnosis is late, the articular and systemic manifestations are the same as in Caucasians, but the autoimmunity seems less. The disease is very active, altering the quality of life. As for its treatment, conventional background therapy still remains effective.

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Prognostic value of cytokines and their soluble receptors and HLA-DR alleles in african patients with severe malaria.

Cited by 3 publications

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Importance of Electrocardiogram for Detection of Preclinical Abnormalities in Patients with Rheumatoid Arthritis without Cardiovascular Events

Importance of Electrocardiogram for Detection of Preclinical Abnormalities in Patients with Rheumatoid Arthritis without Cardiovascular Events

Research of Electrocardiographic and Echocardiographic Abnormalities in Rheumatoid Arthritis without Clinical Cardiovascular Events

Polyarthrite Rhumatoïde en Consultation Rhumatologique à Maradi, Niger

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