Prognostic value of cystatin C in acute coronary syndrome

Abstract

Objective Coronary artery disease associated with an increment with a variety of markers, one of them Cystatin C, in this study we evaluate its role in a prospective study as prognostic marker, and evaluate the correlation between Cystatin C plasma level and variety of acute coronary syndrome (ACS) complications. Methods A total 51 patients who admitted for Merjan Teaching Hospital coronary care unit whom ACS was diagnosis was made depend on history, clinical examination and investigation, and then blood sample was taken to measure plasma level and follow up for 6 months of any new events including new ischemia, rehospitalization, electrical and mechanical complication. Results Patient who admitted with ACS with high level of cystatin C associated with more mortality (P value: 0.09) and more electrical complication (P value: 0.035) and more rehospitalization (P value: 0.01), but failed to show a correlation with mechanical complication. Conclusion Elevated level of Cystatin C in patient admitted to hospital with ACS associated with an increase in hospital mortality, electrical complication, and rehospitalization and lower ejection fraction than a patient with a normal Cystatin C level.

Cystatin-C in patients with acute coronary syndrome: Correlation with ventricular dysfunction, and affected coronary vessels

“…Our study showed the association of higher Cy/C concentration (at the four quartiles) in ACS patients with lower systolic function of the left ventricle reflected by lower EF and this is inconsistent to other analysis like Shuaila et al, who found that higher Cy/C values associated with lower EF. 31 Same outcomes were reported by Moran et al, 32 who revealed that Cy/C can be also a biomarker for cardiac failure. Tayeh et al also showed the association between higher Cy/C level and the lower EF.…”