Prognostic Value of Critical Laboratory Values in Burn Patients: a Retrospective Observational Study

Abstract

Background: Information about the relative importance of critical laboratory values in burn patients has not yet been reported. The purpose of this study was to investigate the morbidity of analytes of critical laboratory values and their association with in-hospital mortality in burn patients.Methods: This was a retrospective observational study. The clinical data and critical laboratory values of burn patients admitted to the Fujian Province Burn Center from July 1, 2017, to May 1, 2021, were downloaded from the Big Data Center of Fujian Medical University Union Hospital. The morbidity of analytes of critical laboratory values and the impact of these critical laboratory results on in-hospital mortality were investigated. Logistic regression analysis was performed to analyse the independent association between analytes of critical laboratory values and in-hospital mortality in burn patients.Results: There were 18 common analytes of critical laboratory values in burn patients in a provincial burn centre, and their morbidity was as follows: hypertroponinemia, alkalemia, positive blood culture (PBC), acidaemia, hypocapnia, hypercapnia, hypocalcaemia, hypoxemia, hyperglycaemia, high activated partial thrombin time (APPT), hypokalaemia, hypernatremia, hypofibrinogenemia, hypohemoglobinemia, hyperkalaemia, hypoglycaemia, hypothrombosis and high prothrombin time (PT). Compared with patients without critical laboratory results, patients with critical laboratory results had a significantly higher in-hospital mortality rate (P < 0.001). The in-hospital mortality of patients with two or more analytes of critical laboratory values was significantly higher than that of patients with one analyte (P < 0.001). Multivariate logistic regression analysis showed that the critical results of hyperglycaemia (P = 0.005), hyperkalaemia (P = 0.030), hypofibrinogenemia (P = 0.015), hypertroponinemia (P = 0.023) and hypoxemia (P = 0.008) were all independently associated with in-hospital mortality.Conclusion: In a group of hospitalized burn patients at a provincial burn centre, the morbidity of analytes of critical laboratory values and their association with in-hospital mortality were investigated for the first time. The critical results of hyperglycaemia, hyperkalaemia, hypofibrinogenemia, hypertroponinemia and hypoxemia were all independent risk factors for in-hospital mortality in burn patients.