Prognostic value of combined serum biomarkers in predicting outcomes in cervical cancer patients

Li, Juan; Cheng, Hao; Zhang, Pengjun; Dong, Zhennan; Tong, Hongli; Han, Jing–Dong Jackie; Guo, Fei; Tian, Yaping

doi:10.1016/j.cca.2013.07.003

Cited by 11 publications

(16 citation statements)

References 23 publications

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“…However, the main goal of this study was to ascertain the rational for using IDO inhibitors in cervical cancer treatment; in contrast, the use of IDO activity as a prognostic marker should be analysed in comparison with serum markers already in use, such as prognostic serum biomarkers in SCC. 31 Our results are in accordance with earlier studies that have shown decreased tryptophan levels, increased kynurenine levels and a high Kyn/Trp ration in the serum of patients with various cancer types. [16][17][18][19]32 In addition, we have previously described the same for endometrial, ovarian and vulvar cancer.…”

Section: Discussionsupporting

confidence: 93%

Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival

et al. 2015

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The expression of the immunomodulating enzyme indoleamine-2,3-dioxygenase (IDO) suppresses T-lymphocyte function, thus correlating with poor survival in a variety of cancer patients. IDO degrades the essential amino acid tryptophan leading to immunosuppressive kynurenines production. In the present study, concentrations of tryptophan, 3-hydroxykynurenine, and kynurenine were measured in pre-treatment serum samples of 251 cervical cancer patients by a mass-spectrometric method (XLC-MS/MS) and IDO activity determined by the kynurenine/tryptophan (Kyn/Trp) ratio. A low concentration of tryptophan was found to be significantly associated with tumors greater than 4 cm and lymph node metastatic spread. Furthermore, significant positive correlations were found between high concentrations of the tryptophan metabolites kynurenine and 3-hydroxykynurenine and advanced disease stage (FIGO >IIA) and lymph node metastases. High levels of kynurenine were further associated with parametrial invasion and tumor size. A high Kyn/Trp ratio was related to lymph node metastasis, FIGO stage, tumor size, parametrial invasion and poor disease-specific survival. These results suggest that IDO activation is linked to poor clinicopathological parameters and worse survival in cervical cancer, warranting the use of IDO inhibitors in future clinical trials.

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Section: Discussionsupporting

confidence: 93%

Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival

et al. 2015

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“…Clinical laboratory echnicians found that combined tumor markers has relatively higher sensitivity in daily work. Researchers found that combined detection had great value in the diagnosis, analysis of effect, recurrence detection and prognosis of cancer (Duffy et al, 2013;Li et al, 2013;Sisik et al, 2013;Wang et al, 2013;Yu et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Combined Detection of Serum Tumor Markers in Diagnosis of Patients with Ovarian Cancer

Bian¹,

Li²,

Kou³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: To explore the predictive value of tumor markers, including cancer antigen 72-4 (CA72-4), cancer antigen 15-3 (CA15-3) and cancer antigen 125 (CA125), in single or combined detection, for the diagnosis of ovarian cancer. Methods: 120 patients diagnosed with ovarian cancer from August 2011 to March 2013 and 80 patients diagnosed with benign ovarian tumors were enrolled in this test, along with 50 health examination women randomly selected from the database as controls. Serum levels of CA72-4, CA15-3 and CA125 in this study were determined by electrochemiluminescence (ECL). Results: Serum levels of CA72-4, CA15-3 and CA125 in ovarian cancer were higher than those in healthy group and benign group (P<0.01).The sensitivity of combined detection of those three tumor markers for diagnosis of ovarian cancer was obviously higher than with single detection with each marker (P<0.01). Conclusions: CA72-4, CA15-3 and CA125 could be a good combination in the diagnosis of ovarian cancer. Patients whose tumor markers continue to increase should be highly suspected of malignancy.

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“…2 The presently used cytomorphological assessment is the most reliable screening method, although it results in high numbers of false-positive and false-negative cervical smears, especially for detection of early stage cancer. 3 Sensitivity and specificity is increased when implementing screening for human papillomavirus (HPV) infection reaching 91 and 88%, respectively, for cervical intraepithelial neoplasia (CIN, precancer stage) grade 2 or worse from healthy.…”

Section: ■ Introductionmentioning

confidence: 99%

A Panel of Regulated Proteins in Serum from Patients with Cervical Intraepithelial Neoplasia and Cervical Cancer

et al. 2014

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We developed a discovery-validation mass-spectrometry-based pipeline to identify a set of proteins that are regulated in serum of patients with cervical intraepithelial neoplasia (CIN) and squamous cell cervical cancer using iTRAQ, label-free shotgun, and targeted mass-spectrometric quantification. In the discovery stage we used a "pooling" strategy for the comparative analysis of immunodepleted serum and revealed 15 up- and 26 down-regulated proteins in patients with early- (CES) and late-stage (CLS) cervical cancer. The analysis of nondepleted serum samples from patients with CIN, CES, an CLS and healthy controls showed significant changes in abundance of alpha-1-acid glycoprotein 1, alpha-1-antitrypsin, serotransferrin, haptoglobin, alpha-2-HS-glycoprotein, and vitamin D-binding protein. We validated our findings using a fast UHPLC/MRM method in an independent set of serum samples from patients with cervical cancer or CIN and healthy controls as well as serum samples from patients with ovarian cancer (more than 400 samples in total). The panel of six proteins showed 67% sensitivity and 88% specificity for discrimination of patients with CIN from healthy controls, a stage of the disease where current protein-based biomarkers, for example, squamous cell carcinoma antigen (SCCA), fail to show any discrimination. Additionally, combining the six-protein panel with SCCA improves the discrimination of patients with CES and CLS from healthy controls.

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Prognostic value of combined serum biomarkers in predicting outcomes in cervical cancer patients

Cited by 11 publications

References 23 publications

Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival

Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival

Clinical Significance of Combined Detection of Serum Tumor Markers in Diagnosis of Patients with Ovarian Cancer

A Panel of Regulated Proteins in Serum from Patients with Cervical Intraepithelial Neoplasia and Cervical Cancer

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