Prognostic value of chromosome 1p allelic loss in colon cancer

Ogunbiyi, Olagunju; Goodfellow, Paul J.; Gagliardi, G.; Swanson, Paul E.; Birnbaum, Elisa H.; Fleshman, James W.; Kodner, Ira J.; Moley, Jeffrey F.

doi:10.1016/s0016-5085(97)70169-0

Cited by 59 publications

(35 citation statements)

References 6 publications

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“…The association between loss of chromosome arm 1p and poor survival has been reported by several investigators using different DNA interrogation techniques ranging from allelic imbalance to genome-wide CGH scanning. 4,[14][15][16] The region of loss we mapped, namely 1p21-31.1 is the same area mapped previously. 4 Chromosome 4 loss is a common aberration in advanced colorectal cancers and metastases.…”

Section: Discussionmentioning

confidence: 99%

Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse

et al. 2006

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A substantial number of patients with early-stage colorectal cancer relapse from metastatic disease. Identification of these patients by genetic profiling of their primary tumours may allow more informed followup and tailored administration of adjuvant therapy. Primary tumours from 70 patients with early-stage and largely microsatellite-stable colorectal cancer were profiled using metaphase-based comparative genomic hybridization (CGH) and the aberrations confirmed independently in a subset of patients using microarraybased CGH. Of the 70 cancers, 61 were amenable to CGH, and follow-up data was available from 56 patients. Genomic aberrations were correlated with patients' survival using univariate, multivariate and Kaplan-Meier survival curves. Metastatic primary tumours exhibited more complex genomic aberrations than non-metastatic primary tumours. Loss of chromosome 4p was an independent prognostic factor in early-stage colorectal cancer using multivariate analysis (Hazard ratio, 9.6; 95% CI, 3.3-28; P ¼ 0.0001). Loss of both chromosome arms 8p and 18q had a statistically significant negative effect on disease-free survival. Moreover, primary tumours with loss of both chromosomes 4 and 14q bestowed poorer prognosis than tumours with loss of any one of the two chromosomes (Po0.0001). Genetic profiling of primary tumours of patients with early-stage colorectal cancer is of significant value in identifying the subset of patients who may relapse with metastatic disease. Accordingly, the molecular genetic features of primary tumours should be considered in the mainstream management of patients with this specific stage of the disease.

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Section: Discussionmentioning

confidence: 99%

Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse

et al. 2006

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“…Multivariate analysis identified Dukes' stage and allelic loss of chromosome 5q as the two independent markers of survival (P = 0.0001). An additional study evaluated allelic loss on chromosome 1p in 116 colorectal tumours, of which 82 (stage I, 17; II, 36; III, 29) were informative and evaluable for survival analysis (Ogunbiyi et al, 1997). Loss of 1p was detected in 22/82 tumours and was associated with a poorer disease-free survival.…”

Section: Allelic Loss/genome Damagementioning

confidence: 99%

Tumour markers of prognosis in colorectal cancer

1998

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“…1p36 and 1p32 regions of chromosome 1 appears to be an independent predictor of poor prognosis in patients with adenocarcinoma of the colon (Ogunbiyi et al, 1997).…”

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confidence: 96%

“…Loss of heterozygosity (LOH) on the short arm of chromosome 1 in solid human tumours has been reported in the following cancer types: breast cancer, neuroblastoma, mesothelioma, melanoma, testis cancer, liver cancer, stomach cancer, phaeochromocytoma, thyroid cancer, meningioma, colorectal cancer, endometrial cancer and Wilms tumour (Mathew et al, 1987;Dracopoli et al, 1989;Chen et al, 1992;Bardi et al, 1993;Taguchi et al, 1993;Bello et al, 1994;Bieche et al, 1994;Mathew et al, 1994;Stock et al, 1994;Yeh et al, 1994;Caron et al, 1995;Kuroki et al, 1995;Munn et al 1995;White et al, 1995;Di Vinci et al, 1996;Ezaki et al, 1996;Ragnarsson et al, 1996;Ogunbiyi et al, 1997;Vargas et al, 1997;Arlt et al, 1996;Steenman et al, 1997). All of these studies strongly indicate that TSGs may be located on the short arm of chromosome 1.…”

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confidence: 99%

“…At least two studies have shown an association between LOH at 1p and amplification of the N-myc proto-oncogene in breast tumours and neuroblastoma (Bieche et al, 1994;Caron et al, 1995). There seems to be an association between LOH at 1p and poor prognosis in patients with neuroblastoma (Caron et al, 1996), breast cancer (Ragnarsson et al, 1996) and colon cancer (Ogunbiyi et al, 1997). LOH at 1p was shown to be an early event in the carcinogenesis of breast cancer (Munn et al, 1995), liver cancer (Kuroki et al, 1995) and colorectal cancer (Di Vinci et al, 1996).…”

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Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival

et al. 1999

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SummaryThe distal half of chromosome 1p was analysed with 15 polymorphic microsatellite markers in 683 human solid tumours at different locations. Loss of heterozygosity (LOH) was observed at least at one site in 369 cases or 54% of the tumours. LOHs detected ranged from 30-64%, depending on tumour location. The major results regarding LOH at different tumour locations were as follows: stomach, 20/38 (53%); colon and rectum, 60/109 (55%); lung, 38/63 (60%); breast, 145/238 (61%); endometrium, 18/25 (72%); ovary, 17/31 (55%); testis, 11/30 (37%); kidney, 22/73 (30%); thyroid, 4/14 (29%); and sarcomas, 9/14 (64%). High percentages of LOH were seen in the 1p36.3, 1p36.1, 1p35-p34.3, 1p32 and 1p31 regions, suggesting the presence of tumour-suppressor genes. All these regions on chromosome 1p show high LOH in more than one tumour type. However, distinct patterns of LOH were detected at different tumour locations. There was a significant separation of survival curves, with and without LOH at chromosome 1p, in the breast cancer patients. Multivariate analysis showed that LOH at 1p in breast tumours is a better indicator for prognosis than the other variables tested in our model, including nodal metastasis.

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Prognostic value of chromosome 1p allelic loss in colon cancer

Cited by 59 publications

References 6 publications

Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse

Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse

Tumour markers of prognosis in colorectal cancer

Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival

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