Prognostic value of central venous-arterial pCO2 difference in severe sepsis and septic shock patients

Machado, Flávia Soares; Guarnieri, Andreia; Freitas, F; Assunção, Murillo Santucci César de; Mazza, Bruno Franco; Jackiu, M

doi:10.1186/cc8387

Cited by 1 publication

(1 citation statement)

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“…They found a higher Pcv-aCO2 gradient at Time 0 (6.5±3.0 vs. 3±1.8,) and Time 6 (8±4 vs. 3±2) in non survivors vs. survivors respectively (9). In contrary, Machado and colleagues disagree with a study done on 43 patients with severe sepsis and septic shock, who found that ΔPCO 2 and SvcO 2 and its trends are unrelated to the SOFA score in first 24 hours (10) .…”

Section: Discussionmentioning

confidence: 85%

Hypo Perfusion Markers as Therapeutic and Prognostic Tools for Septic Patients

Ali

Elsharnouby

Esmat

et al. 2020

Ain Shams Medical Journal

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Background: Venous-to-arterial carbon dioxide difference (Pv-aCO 2) and central venous oxygen saturation (ScvO 2) may reflect the adequacy of blood flow during septic shock states. We sought to test whether the development of Pv-aCO 2 and ScvO 2 during the early phases of resuscitation is related to multi-organ dysfunction and outcomes in a population of septic shock patients resuscitated targeting the usual oxygen-derived and hemodynamic parameters. Aim of the Work: To assess the central venous-arterial carbon dioxide difference (Pv-aCO 2) as a goal in goal directed therapy of sepsis resuscitation in comparison to central venous oxygen saturation (ScvO 2) and to test for their prognostic values. Patients and Methods: This prospective observational study was performed in a 24-bed mixed ICU in a university-affiliated hospital. We examined all septic patients with a new episode admitted to the emergency room or proceeding from clinical wards during a 24month period. After approval by Ethical Medical Committee and obtaining informed consent, simultaneous blood samples were collected from the central venous line and the arterial catheter for obtaining venous and arterial gases respectively at (T0), and 6 hours (T6), 12 hours (T12) and 24 hours (T24) later. Patients were classified into four groups; two group (30patients) (A1 and A2) according to PcvO2 gap and another two groups (30patients) (B1 and B2) according to Central venous oxygen saturation. Group (A1) Decreasing Pcv-aCO2 (high at T0, declining at T6), Group (A2) Persistently high Pcv-aCO2 (high at T0 and T6), Group (B1) Increasing Central venous oxygen saturation (less than 70% at T0, increasing at T6), Group (B2) Decreasing Central venous oxygen saturation (less than 70%at T0 and decreasing T6). Results: Sixty-eight septic critically ill patients were included in this study. However; 8 patients were excluded from the study. Among the included patients in the study, 3 patients were excluded as they developed acute coronary syndrome, 4 patients refused to complete the treatment and discharged against medical advice, and 1 patient developed an ischemic cerebral vascular stroke. The final sample was therefore 60 patients. In this study, Central veno-arterial PCO2 gap and ScvO2 are considered as surrogate markers of the payment of the oxygen debt and early predictors of clinical outcome and organ dysfunction in the ICU. As regard the study, Central veno-arterial PCO2 gap is predictors for resuscitation in septic patients. As regard A Group, there was significant statistical difference between mortality and survival at T6, T12 and T24. However; regarding B Group, there was significant statistical difference between mortality and survival at

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Section: Discussionmentioning

confidence: 85%