Prognostic Value of CD45Ro<sup>+</sup> T-Cell Expression in Patients With Oral Squamous Cell Carcinoma

Koike, Kazushige; Nishiyama, Koyo; Dehari, Hironari; Ogi, Kazuhiro; Sasaki, Takanori; Sasaki, Shota; Sasaya, Takashi; Tsuchihashi, Kei; Sonoda, Tomoko; Hasegawa, Tadashi; Hiratsuka, Hiroyoshi; Miyazaki, Akira

doi:10.21873/anticanres.15262

Cited by 5 publications

(8 citation statements)

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“…[ 21 , 30 , 31 , 32 ]. CD45RO+ TILs in oral squamous cell carcinoma have been investigated multiple times and were unanimously described as a positive prognostic factor [ 17 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis by Hu et al concluded that CD45RO+ T cells are a “valuable biomarker for prognostic prediction of human solid malignancies”. Their positive prognostic value has been demonstrated for colorectal cancer (CRC), hepatocellular cancer (HCC), gastric cancer (GC), esophageal cancer (EC), and oral squamous cell carcinoma (OSCC) [ 12 , 17 , 18 , 19 ]. In CRC, CD45RO+ T cells strongly correlated with tumor downstaging and long-term outcome after neoadjuvant hypofractionated radiotherapy, indicating a possible role for memory T cells in patient stratification and detection of the most suitable candidates for radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

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The Prognostic and Predictive Significance of Tumor-Infiltrating Memory T Cells Is Reversed in High-Risk HNSCC

Hartan

Schnellhardt

Büttner‐Herold

et al. 2022

Cells

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Tumor-infiltrating CD45RO+ memory T cells have unanimously been described as a positive prognostic factor in head and neck squamous cell carcinomas (HNSCCs). Here, we investigated the long-term prognostic relevance of CD45RO+ memory T cells in HNSCC with special regard to the influence of clinical characteristics. Pre-treatment biopsy samples from 306 patients with predominantly advanced HNSCC were analyzed. Immunohistochemistry was used to stain tissue microarrays for CD45RO+ memory T cells. CD45RO cell densities were semi-automatically registered and used for survival analysis. High CD45RO+ cell densities were clearly associated with prolonged overall survival (OS) and recurrence-free survival as well as no evidence of disease status after 10 years (p < 0.05). In contrast, the prognostic significance of tumor-infiltrating memory T cells was completely reversed in high-risk groups: in poorly differentiated tumors (G3, G4) and in cases with lymph node involvement (N+), high memory T cell densities correlated with reduced 10-year OS (p < 0.05). In conclusion, an increased density of tumor-infiltrating CD45RO+ cells in HNSCC can be a positive as well as a negative prognostic factor, depending on disease stage and histological grade. Therefore, if CD45RO+ cell density is to be used as a prognostic biomarker, further clinical characteristics must be considered.

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“…[ 21 , 30 , 31 , 32 ]. CD45RO+ TILs in oral squamous cell carcinoma have been investigated multiple times and were unanimously described as a positive prognostic factor [ 17 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Prognostic and Predictive Significance of Tumor-Infiltrating Memory T Cells Is Reversed in High-Risk HNSCC

Hartan

Schnellhardt

Büttner‐Herold

et al. 2022

Cells

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“…Naturally, HLA markers are essential for antigen presentation and display a pivotal role in antitumor immunity by enhancing immunosurveillance and preventing immune escape. Additionally, high HLA class I expression in OSCC shows a significantly positive connection with a better prognosis (Koike et al, 2020;Anderson et al, 2021). Besides, it is worth emphasizing that various immune cells in the TME participate in anti-tumor immune responses as main components.…”

Section: Discussionmentioning

confidence: 98%

An oxidative stress-related prognostic signature for indicating the immune status of oral squamous cell carcinoma and guiding clinical treatment

et al. 2022

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Oral squamous cell carcinoma (OSCC) is the eighth most common cancer worldwide and presents high mortality. Oxidative stress, caused by reactive oxygen species accumulation, plays a crucial role in tumorigenesis, cancer progression, and drug resistance. Nevertheless, the specific prognostic and clinical values of oxidative stress-related genes (OSGs) in OSCC remain unclear. Here, we developed an oxidative stress-related prognostic signature according to mRNA expression data from The Cancer Genome Atlas (TCGA) database and evaluated its connections with the prognosis, clinical features, immune status, immunotherapy, and drug sensitivity of OSCC through a series of bioinformatics analyses. Finally, we filtered out six prognostic OSGs to construct a prognostic signature. On the basis of both TCGA-OSCC and GSE41613 cohorts, the signature was proven to be an independent prognostic factor with high accuracy and was confirmed to be an impactful indicator for predicting the prognosis and immune status of patients with OSCC. Additionally, we found that patients with high-risk scores may obtain greater benefit from immune checkpoint therapy compared to those with low-risk scores, and the risk score presented a close interaction with the tumor microenvironment and chemotherapy sensitivity. The prognostic signature may provide a valid and robust predictive tool that could predict the prognosis and immune status and guide clinicians to develop personalized therapeutic strategies for patients with OSCC.

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“…HLA class I expression appears to be lost or downregulated on the tumor cell surface, which could represent a mechanism by which neoplastic cells escape killing by CTLs, allowing tumor dissemination and metastasis (Pistillo et al, 2000). HLA class I antigen downregulation has been used as a prognostic biomarker in esophageal cancer (Hosch et al, 1997), melanoma (Kageshita et al, 1999), lung cancer (Kikuchi et al, 2007), ovarian cancer (Vitale et al, 2005), renal cell carcinoma (Kitamura et al, 2007), bladder cancer (Homma et al, 2009), and oral squamous cell carcinoma (Koike et al, 2020) and has improved the survival of patients. In our study, the expression levels of class I HLA molecules, which are responsible for antigen presentation to tumor-killing T-cells, and the expression levels of class II HLA molecules, which are responsible for antigen presentation to helper T-cells, were decreased in some patients.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing

Tang

et al. 2023

Front. Genet.

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Background: The aim of this study was to investigate the underlying mechanisms of adenoid cystic carcinoma (ACC) at the transcriptome level.Materials and methods: We obtained paired tumor and normal salivary gland tissues from 15 ACC patients, which were prepared for RNA sequencing.Results: Gene enrichment analysis revealed that the upregulated pathways were mainly involved in axonogenesis, and the downregulated pathways were mainly related to leukocyte migration, the adaptive immune response, lymphocyte-mediated immunity, and the humoral immune response. T-cells, B-cells and NK cells showed low infiltration in ACC tissues. In addition to the gene fusions MYB-NFIB and MYBL1-NFIB, a new gene fusion, TVP23C-CDRT4, was also detected in 3 ACC tissues. PRAME was significantly upregulated in ACC tissues, while antigen-presenting human leukocyte antigen (HLA) genes were downregulated.Conclusion: We found a new gene fusion, TVP23C-CDRT4, that was highly expressed in ACC. PRAME may be an attractive target for ACC immunotherapy.

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Prognostic Value of CD45Ro⁺ T-Cell Expression in Patients With Oral Squamous Cell Carcinoma

Cited by 5 publications

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The Prognostic and Predictive Significance of Tumor-Infiltrating Memory T Cells Is Reversed in High-Risk HNSCC

The Prognostic and Predictive Significance of Tumor-Infiltrating Memory T Cells Is Reversed in High-Risk HNSCC

An oxidative stress-related prognostic signature for indicating the immune status of oral squamous cell carcinoma and guiding clinical treatment

Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing

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Prognostic Value of CD45Ro+ T-Cell Expression in Patients With Oral Squamous Cell Carcinoma

Cited by 5 publications

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The Prognostic and Predictive Significance of Tumor-Infiltrating Memory T Cells Is Reversed in High-Risk HNSCC

The Prognostic and Predictive Significance of Tumor-Infiltrating Memory T Cells Is Reversed in High-Risk HNSCC

An oxidative stress-related prognostic signature for indicating the immune status of oral squamous cell carcinoma and guiding clinical treatment

Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing

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Prognostic Value of CD45Ro⁺ T-Cell Expression in Patients With Oral Squamous Cell Carcinoma