Prognostic value of CD4<sup>+</sup>CD25<sup>+</sup> Tregs as a valuable biomarker for patients with sepsis in ICU

Chen, Kun; Zhou, Qin; Shan, Hong‐Wei; Li, Wenfang; Lin, Zongming

doi:10.5847/wjem.j.1920-8642.2015.01.007

Cited by 30 publications

(31 citation statements)

References 22 publications

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“…The analysis of T regs from days 1 and 3 of life in these patients revealed no significant difference. Interestingly, recent studies in adult patients with severe sepsis or septic shock demonstrated an increase in number and function of T regs during the course of disease and a positive correlation between T reg level and the mortality rate of the patients . We hypothesize that T regs may cause a temporary down‐regulation of central host immune functions after birth and therefore enable establishment of microbiota.…”

Section: Discussionmentioning

confidence: 83%

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Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis

Pagel

Hartz

Figge

et al. 2016

Clinical and Experimental Immunology

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SummaryThe predisposition of preterm neonates to invasive infection is, as yet, incompletely understood. Regulatory T cells (T regs ) are potential candidates for the ontogenetic control of immune activation and tissue damage in preterm infants. It was the aim of our study to characterize lymphocyte subsets and in particular CD41 CD25 1 forkhead box protein 3 (FoxP3) 1 T regs in peripheral blood of well-phenotyped preterm infants (n 5 117; 23 1 0 -36 1 6 weeks of gestational age) in the first 3 days of life in comparison to term infants and adults. We demonstrated a negative correlation of T reg frequencies and gestational age. T regs were increased in blood samples of preterm infants compared to term infants and adults. Notably, we found an increased T reg frequency in preterm infants with clinical early-onset sepsis while cause of preterm delivery, e.g. chorioamnionitis, did not affect T reg frequencies. Our data suggest that T regs apparently play an important role in maintaining maternal-fetal tolerance, which turns into an increased sepsis risk after preterm delivery. Functional analyses are needed in order to elucidate whether T regs have potential as future target for diagnostics and therapeutics.

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Section: Discussionmentioning

confidence: 83%

“…Despite the important role of T regs in mediating immunosuppression in adult patients with severe sepsis , to what extent T regs contribute to the distinct susceptibility to infection of preterm infants is still unknown .…”

Section: Introductionmentioning

confidence: 99%

Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis

Pagel

Hartz

Figge

et al. 2016

Clinical and Experimental Immunology

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“…This phenomenon, recapitulated in CLP‐mice, was totally abrogated by using FOXP3 siRNA inhibiting Treg functions . Recent clinical works aligned with initial descriptions . Of note, Treg overexpression of CD39 in septic patients has been reported to be significantly associated with mortality .…”

Section: Lymphocytesmentioning

confidence: 65%

Sepsis‐induced immune alterations monitoring by flow cytometry as a promising tool for individualized therapy

Monneret

Venet

2015

Cytometry Part B Clinical

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Septic syndromes remain a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units. While sepsis has, for long, been solely described as inducing a tremendous systemic inflammatory response, novel findings indicate that sepsis indeed initiates a more complex immunologic response that varies over time, with the concomitant occurrence of both pro-and anti-inflammatory mechanisms. As a resultant, after a short proinflammatory phase, septic patients enter a stage of protracted immunosuppression. This is illustrated in those patients by reactivation of dormant viruses (CMV or HSV) or infections due to pathogens, including fungi, which are normally pathogenic solely in immunocompromised hosts. Although mechanisms are not totally understood, these alterations might be directly responsible for worsening outcome in patients who survived initial resuscitation as nearly all immune functions are deeply compromised. Indeed, the magnitude and persistence over time of these dysfunctions have been associated with increased mortality and health-care associated infection rate. Consequently, new promising therapeutic avenues are currently emerging from those recent findings such as adjunctive immunostimulation (IFN-g, GM-CSF, IL-7, anti-PD1/L1 antibodies) for the most immunosuppressed patients. Nevertheless, as there is no clinical sign of immune dysfunctions, the prerequisite for such therapeutic intervention relies on our capacity in identifying the patients who could benefit from immunostimulation. To date, the most robust biomarkers of sepsis-induced immunosuppression are measured by flow cytometry. Of them, the decreased expression of monocyte HLA-DR appears as a "gold standard." This review reports on the mechanisms sustaining sepsis-induced immunosuppression and its related biomarkers measurable by flow cytometry. The objective is to integrate the most recent facts in an up-to-date account of clinical results, flow cytometry aspects as well as issues in results standardization for multicenter studies. V C 2015 International Clinical Cytometry Society

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“…CD4 + CD25 + Tregs are modulator of adaptive and innate immune responses (Bakır et al, 2016;Kanakasabai et al, 2012). Some cytokines prevent the immune system, for example, transforming growth factor-beta (TGF-β) and IL-10 produced by Tregs, which play an important role in tolerating the immune system in sepsis (Chen, Zhou, Shan, Li, & Lin, 2015;Sharma, Yang, Matsuo, & Wang, 2015).…”

Section: Immunomodulatory Effect Of Curcumin On T Cellmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies.

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Prognostic value of CD4⁺CD25⁺ Tregs as a valuable biomarker for patients with sepsis in ICU

Abstract: BACKGROUND: Sepsis is a common complication of infections, burns, traumas, surgeries, poisonings, and post-cardiopulmonary resuscitation. The present study aimed to investigate prognostic value of CD4 + CD25+ regulatory T cells (Treg) in peripheral blood of patients with sepsis.

Cited by 30 publications

References 22 publications

Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis

Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis

Sepsis‐induced immune alterations monitoring by flow cytometry as a promising tool for individualized therapy

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

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Prognostic value of CD4+CD25+ Tregs as a valuable biomarker for patients with sepsis in ICU

Abstract: BACKGROUND: Sepsis is a common complication of infections, burns, traumas, surgeries, poisonings, and post-cardiopulmonary resuscitation. The present study aimed to investigate prognostic value of CD4 + CD25+ regulatory T cells (Treg) in peripheral blood of patients with sepsis.

Cited by 30 publications

References 22 publications

Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis

Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis

Sepsis‐induced immune alterations monitoring by flow cytometry as a promising tool for individualized therapy

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

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Resources

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Prognostic value of CD4⁺CD25⁺ Tregs as a valuable biomarker for patients with sepsis in ICU