Prognostic value of cardiovascular magnetic resonance T1 mapping techniques in non-ischemic dilated cardiomyopathy: A systematic review and meta-analysis

Kiaos, Apostolos; Antonakaki, Dimitra; Bazmpani, Maria-Anna; Karvounis, Charalambos; Rimoldi, Ornella; Karamitsos, Theodoros D.

doi:10.1016/j.ijcard.2020.04.052

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…Of clinical importance, both native T1 and ECV have been described as independent prognostic factors for all-cause mortality or heart failure hospitalisation. 24 25 Native T1 was even superior to LVEF in predicting all-cause mortality and major adverse cardiocerebrovascular events. 25 This suggests that exercise during chemotherapy could be useful to offset the increased CVD risk in BC survivors.…”

Section: Discussionmentioning

confidence: 91%

Effects of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity

Naaktgeboren,

Stuiver,

van Harten

et al. 2023

Open Heart

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ObjectiveAnimal data suggest that exercise during chemotherapy is cardioprotective, but clinical evidence to support this is limited. This study evaluated the effect of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity.MethodsThis is a follow-up study of two previously performed randomised trials in patients with breast cancer allocated to exercise during chemotherapy or non-exercise controls. Cardiac imaging parameters, including T1 mapping (native T1, extracellular volume fraction (ECV)), left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS), cardiorespiratory fitness, and physical activity levels, were acquired 8.5 years post-treatment.ResultsIn total, 185 breast cancer survivors were included (mean age 58.9±7.8 years), of whom 99% and 18% were treated with anthracyclines and trastuzumab, respectively. ECV and Native T1 were 25.3%±2.5% and 1026±51 ms in the control group, and 24.6%±2.8% and 1007±44 ms in the exercise group, respectively. LVEF was borderline normal in both groups, with an LVEF<50% prevalence of 22.5% (n=40/178) in all participants. Compared with control, native T1 was statistically significantly lower in the exercise group (β=−20.16, 95% CI −35.35 to −4.97). We found no effect of exercise on ECV (β=−0.69, 95% CI −1.62 to 0.25), LVEF (β=−1.36, 95% CI −3.45 to 0.73) or GLS (β=0.31, 95% CI −0.76 to 1.37). Higher self-reported physical activity levels during chemotherapy were significantly associated with better native T1 and ECV.ConclusionsIn long-term breast cancer survivors, exercise and being more physically active during chemotherapy were associated with better structural but not functional cardiac parameters. The high prevalence of cardiac dysfunction calls for additional research on cardioprotective measures, including alternative exercise regimens.Trial registration numberNTR7247.

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Section: Discussionmentioning

confidence: 91%

Effects of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity

Naaktgeboren,

Stuiver,

van Harten

et al. 2023

Open Heart

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“…Native T1 and extracellular volume (ECV) calculation can identify another type of fibrosis, namely diffuse interstitial myocardial fibrosis, which is due to reactive accumulation of collagen in the interstitial space [ 9 ], as opposed to the above-mentioned focal replacement myocardial fibrosis. It has been shown to be an independent negative prognostic factor, which correlates with ventricular volumes, contractility, and diastolic dysfunction [ 10 - 12 ]. CMR examination indications in DCM: Differential diagnosis between ischemic vs non-ischemic etiology [ 13 - 14 ].…”

Section: Reviewmentioning

confidence: 99%

“…Left ventricle ejection fraction (LVEF) is an important prognostic factor in the ischemic heart disease and its value is establishing the need of ICD and CRT therapy systems [ 85 - 86 ]. With the conventional T2-weighted images, CMR can detect myocardial edema and can differentiate between acute and chronic infarcts [ 10 , 87 - 88 ].…”

Section: Reviewmentioning

confidence: 99%

Cardiovascular Magnetic Resonance Imaging in Myocardial Disease

Popa,

Amzulescu,

Bugeac

et al. 2024

Cureus

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Cardiovascular magnetic resonance (CMR) is the central non-invasive imaging investigation for the evaluation of myocardial disease. It is the well-established gold standard for measuring cardiac chamber volumes, systolic function, and left ventricular mass, and it brings unique information for therapeutic decisions. In addition, its tissue characterization capability, through T1, T2, and T2* mapping, as well as early and late gadolinium enhancement (LGE) sequences, allows to differentiate in many cases among ischemic, inflammatory, and infiltrative heart disease and permits the quantification of myocardial fibrosis, providing valuable diagnostic and prognostic information. This review aims to highlight the main CMR features of different cardiomyopathies.

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“…They highlighted that T1 mapping was an independent predictor of all-cause mortality in DCM. A recent metaanalysis [49] showed the significant prognostic value of T1 mapping in a population of 1242 patients with DCM. Specifically, HR was 1.20 for a composite outcome of mortality and morbidity.…”

Section: T1 and Ecv Quantification In Dcmmentioning

confidence: 99%

Current Insights and Novel Cardiovascular Magnetic Resonance-Based Techniques in the Prognosis of Non-Ischemic Dilated Cardiomyopathy

Perone,

Dentamaro,

La Mura

et al. 2024

JCM

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Cardiac magnetic resonance (CMR) imaging has an important emerging role in the evaluation and management of patients with cardiomyopathies, especially in patients with dilated cardiomyopathy (DCM). It allows a non-invasive characterization of myocardial tissue, thus assisting early diagnosis and precise phenotyping of the different cardiomyopathies, which is an essential step for early and individualized treatment of patients. Using imaging techniques such as late gadolinium enhancement (LGE), standard and advanced quantification as well as quantitative mapping parameters, CMR-based tissue characterization is useful in the differential diagnosis of DCM and risk stratification. The purpose of this article is to review the utility of CMR in the diagnosis and management of idiopathic DCM, as well as risk prediction and prognosis based on standard and emerging CMR contrast and non-contrast techniques. This is consistent with current evidence and guidance moving beyond traditional prognostic markers such as ejection fraction.

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Prognostic value of cardiovascular magnetic resonance T1 mapping techniques in non-ischemic dilated cardiomyopathy: A systematic review and meta-analysis

Cited by 13 publications

References 24 publications

Effects of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity

Effects of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity

Cardiovascular Magnetic Resonance Imaging in Myocardial Disease

Current Insights and Novel Cardiovascular Magnetic Resonance-Based Techniques in the Prognosis of Non-Ischemic Dilated Cardiomyopathy

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