Prognostic value of CA125 in advanced heart failure patients

Abstract

Introduction: Serum levels of CA125 are often high in advanced heart failure (AHF) patients. Aim: To determine the predictive value of CA125 in forecasting the occurrence of death or cardiac transplantation in an AHF population. Methods: 88 AHF patients referred for heart transplantation were divided into 2 groups based on CA125 levels: normal (CA125 b 38 U/mL) and elevated (≥ 38 U/mL). Events (death or heart transplant) were monitored over a period of 13 ± 7 months after CA125 determination. Results: Patients with elevated CA125 (n = 65) had significantly lower blood pressure, body mass index, serum sodium and peak exercise oxygen consumption, while B-type natriuretic peptide levels were significantly higher. The combined primary endpoint (death or heart transplant) rate was 39.4% and 62.3% in normal and elevated CA125 groups, respectively (p = 0.029). Multivariate regression analysis showed that CA125 and sodium levels were the only independent predictors of the combined endpoint. Conclusion: In AHF patients, plasma CA125 was an effective prognostic marker. Its determination may contribute to better risk stratification in this population.

CA125 and immunoinflammatory activity in acute heart failure

“…In agreement with previous observations [1,2], Monteiro et al [3] reported that carbohydrate antigen 125 (CA125) was an independent predictor of increased mortality and heart transplantation in patients with acute heart failure (HF). The exact mechanism responsible of CA125 elevation in HF patients is not totally elucidated.…”

“…Coronary stents pose a challenge in the perioperative period. Given the anecdotal evidence and case series suggesting that Drug Eluting Stents (DES) may be more vulnerable to thrombosis on discontinuation of antiplatelet agents (APT) than are bare-metal stents (BMS) [1][2][3][4], we sought to quantify this risk. We evaluated all patients who underwent noncardiac surgery (NCS) in a 3-year period.…”

Biomarkers in Aortic Stenosis: A Systematic Review

“…70,71 CA-125 levels are associated with the presence of symptoms and increased risk of adverse events and appears to have incremental value over BNP, the logistic EuroSCORE, and New York Heart Association Class. 72,73 CA-125 also correlates with echocardiographic measures of LV and atrial size and function, and appears not to be influenced by renal function, age, or body mass index.…”

CA125—A Test with a Change of Heart

“…CA125 is now recognised as a strong indicator of survival [75,76]. Filipiak et al [77] have also found that simultaneous measurement of BNP and CA125 gives the highest predictive ability for death risk in heart failure and showed that while a low left ventricular mass index or low eGFR have mortality odds ratios of 18 and 19 respectively, CA125 in combination with NT-proBNP had a mortality odds ratio of 493!…”