Prognostic value of C-reactive protein/albumin ratio in ST-segment elevation myocardial infarction

Aşkın, Lütfü; Tanrıverdi, Okan; Tıbıllı, Hakan; Türkmen, Serdar

doi:10.1556/1646.11.2019.20

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…In other studies with stable CAD patients treated with PCI, CRP independently associated with an increased risk of 1-year mortality ( 16 ). In STEMI patients, CAR was found to be effective as prognostic marker for in-hospital and long-term all-cause mortality ( 17 ). As already known, our study determined the relationship between CRP and myocardial ischemia.…”

Section: Discussionmentioning

confidence: 99%

Value of C-reactive Protein/Albumin Ratio for Predicting Ischemia in Myocardial Perfusion Scintigraphy

Efe

Candan²,

Gündoğan³

et al. 2020

Mirt

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Objectives: Several studies demonstrate the relationship between coronary artery disease and inflammatory parameters. Nevertheless, there is paucity of data regarding the role of high sensitivity (hs)-C-reactive protein (CRP) to albumin ratio (CAR) in patients with ischemia on gated single photon emission tomography (SPECT) myocardial perfusion imaging (MPI). This study was aimed at demonstrating the relationship between CAR and the occurrence of ischemia on gated SPECT MPI. Methods: We retrospectively evaluated 2.048 referred patients for gated SPECT MPI from a cardiology outpatient clinic between October 2017 and June 2019. After applying exclusion criteria and measuring serum CRP and albumin levels, we included 126 patients in the study. We then classified subjects into different groups according to the absence or presence of ischemia on gated SPECT MPI. Results: According to laboratory findings, hs-CRP and CAR were significantly higher in the ischemia group, while the serum albumin was significantly lower in ischemia group (p<0.05 for each). The independent predictors of presence of ischemia in multivariate analysis were hypertension and CAR (CAR; odds ratio: 5.720, 95% confidence interval: 2.697-12.133, p<0.001). The optimal value of CAR for presence of ischemia was 0.96 with 76% sensitivity and 71% specificity. Conclusion: We found CAR values as a predictor for ischemia before MPI.

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Section: Discussionmentioning

confidence: 99%

Value of C-reactive Protein/Albumin Ratio for Predicting Ischemia in Myocardial Perfusion Scintigraphy

Efe

Candan²,

Gündoğan³

et al. 2020

Mirt

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“…Specifically, we examine blood pressure and inflammation in recent movers to assess whether relocating to another city is associated with increased cardiovascular disease risk. Higher blood pressure and higher inflammation, as measured by the C‐reactive protein to albumin ratio, are both independently linked to increased cardiovascular disease risk (Askin et al., 2020; Fuchs & Whelton, 2020; Wada et al., 2017; Wu et al., 2015). We also examine whether this hypothesized increased risk is diminished after people live in a new city for 3 months and start to rebuild their local social network.…”

Section: Introductionmentioning

confidence: 99%

Social integration after moving to a new city predicts lower systolic blood pressure

et al. 2021

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Residential mobility is linked to higher incidence of cardiovascular disease (CVD) and mortality. A mechanism by which residential relocation may impact health is through the disruption of social networks. To examine whether moving to a new city is associated with increased CVD risk and whether the extent to which movers rebuild their social network after relocating predicts improved CVD risk and psychosocial well‐being, recent movers (n = 26), and age‐ and sex‐matched nonmovers (n = 20) were followed over 3 months. Blood pressure, C‐reactive protein/albumin ratio (CRP/ALB), social network size, and psychosocial well‐being were measured at intake (within 6 weeks of residential relocation for movers) and 3 months later. Multiple regression indicated higher systolic blood pressure (SBP) for movers (M = 107.42, SD = 11.39), compared with nonmovers (M = 102.37, SD = 10.03) at intake, though this trend was not statistically significant. As predicted, increases in movers' social network size over 3 months predicted decreases in SBP, even after controlling for age, sex, and waist‐to‐hip ratio, b = −2.04 mmHg, 95% CI [−3.35, −.73]. Associations between increases in movers' social ties and decreases in depressive symptoms and stress were in the predicted direction but did not meet the traditional cutoff for statistical significance. Residential relocation and movers' social network size were not associated with CRP/ALB in this healthy sample. This study provides preliminary evidence for increased SBP among recent movers; furthermore, it suggests that this elevation in CVD risk may decrease as individuals successfully rebuild their social network.

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Imbalance Between Angiotensin II and Kallikrein in Patients With ST-Segment Elevation Myocardial Infarction: A Case-Control Emergency Room Study

Dai,

Yin,

Wang

et al. 2024

Angiology

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The present study aimed to investigate the balance between angiotensin II (Ang-II) and kallikrein (KLK1) in the pathogenesis of ST-segment elevation acute myocardial infarction (STEMI). The study included a total of 261 participants: 151 STEMI patients and 110 individuals with normal coronary arteries. The plasma levels of Ang-II and KLK1 were measured using enzyme-linked immunosorbent assays (ELISA). Multivariate logistic regression analysis indicated that the plasma levels of Ang-II, KLK1 and the ratio of Ang-II and KLK1 (Ang-II/KLK1) independently correlated with the presence of STEMI. Furthermore, we found independent associations between STEMI and smoking, cholesterol (CHO), high-density lipoprotein cholesterol (HDL-c), as well as age. The ratio of Ang-II/KLK1 correlated with the plasma level of the inflammatory cytokine, interleukin-6 (IL-6). Both Ang-II and KLK1 levels are significantly elevated in patients with STEMI. An increased Ang-II/KLK1 ratio may result in the over-activation of Ang-II and exacerbate the progression of STEMI( P = .046). In conclusion, we have demonstrated, for the first time, an Ang-II and KLK1 imbalance in patients with STEMI.

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Prognostic value of C-reactive protein/albumin ratio in ST-segment elevation myocardial infarction

Cited by 5 publications

References 38 publications

Value of C-reactive Protein/Albumin Ratio for Predicting Ischemia in Myocardial Perfusion Scintigraphy

Value of C-reactive Protein/Albumin Ratio for Predicting Ischemia in Myocardial Perfusion Scintigraphy

Social integration after moving to a new city predicts lower systolic blood pressure

Imbalance Between Angiotensin II and Kallikrein in Patients With ST-Segment Elevation Myocardial Infarction: A Case-Control Emergency Room Study

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