Prognostic Value of C‐Reactive Protein, Fibrinogen, Interleukin‐6, and Macrophage Colony Stimulating Factor in Severe Unstable Angina

Abstract

SummaryBackground: Inflammatory process plays an important role in the pathogenesis of acute coronary syndromes.Hypothesis: The study was undertaken to evaluate whether admission levels of C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), and macrophage colony stimulating factor (MCSF) can predict short-term prognosis in patients with unstable angina.Methods: C-reactive protein, fibrinogen, IL-6, and MCSF were measured on admission in 141 consecutive patients, aged 59 ± 10 years, with unstable angina (Braunwald class IIIb). Patients were divided into two groups according to their in-hospital outcome: Group 1 comprised 77 patients with a complicated course (2 died, 15 developed nonfatal myocardial infarction, and 60 had recurrence of angina), and Group 2 comprised 64 patients with an uneventful course.Results: Admission median levels of CRP (8.8 vs. 3.1 mg/l, p = 0.0002), fibrinogen (392 vs. 340 mg/dl, p = 0.008), .5 pg/ml, p = 0.03), and MCSF (434 vs. 307 pg/ml, p = 0.0001) were higher in Group 1 than in Group 2. The MCSF levels were an independent risk factor for in-hospital events, with an adjusted odds ratio for eventful in-hospital outcome of 3.3 (95% confidence interval 1-10.9, p = 0.04), and correlated with levels of IL-6 (r s = 0.52, p = 0.0001), CRP (rs = 0.43, p = 0.0001), and fibrinogen (rs = 0.25, p = 0.004).Conclusions: These findings suggest that among the studied inflammatory indices only increased admission levels of

Clinical outcomes after drug-eluting stent implantation for unprotected left main coronary artery disease

“…(16,17) Moreover, some authors observed how increased MCSF levels in patients with unstable angina may predict a worse prognosis during in hospital stay and in a mid to long term period. (16,(18)(19)(20)(21) This study confirmed the importance of MCSF as a prognostic marker in acute coronary syndrome with its levels higher in patients with worse in hospital stay and more diseased coronary vessel. Moreover, for the first time the authors have observed the abserved the absence of significant statistical differences of its concentrations between STEMI and NSTEMI patients.…”

Xuezhikang Decreases Serum Lipoprotein(a) and C-reactive Protein Concentrations in Patients with Coronary Heart Disease

“…Lp(a) may act as an acute-phase reactant (24 ) and thus possibly contribute to acute cardiac events. Moreover, many studies have demonstrated a significant relationship between Lp(a) and CRP (13,14 ) and other inflammatory factors, such as fibrinogen, interleukin-6 (7 ), complement 3 and 4 (8 ), and soluble cellular adhesion molecules (9 ), which suggests that Lp(a) may be involved in atherogenesis through an inflammatory mechanism.…”

C-Reactive Protein Levels and Atrial Fibrillation After Cardiac Surgery in Women

“…(11) Extensive data have shown that CRP levels provide independent prediction of adverse cardiovascular events such as myocardial infarction and stroke. (11)(12)(13)(14)(15) The role of CRP concentrations in identifying risk for complications after cardiac surgery is increasingly under investigation. (16,17) A link between CRP levels and atrial fibrillation supports the notion that inflammation enhances susceptibility to the arrhythmias regardless of whether the surgery is performed with our without cardiopulmonary bypass.…”