1999
DOI: 10.1097/00003246-199901000-00044
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Prognostic value of blood lactate, base deficit, and oxygen-derived variables in an LD50 model of penetrating trauma

Abstract: Arterial lactate is a stronger index of blood loss after penetrating trauma than base deficit or oxygen-derived hemodynamic variables. The reliability of arterial lactate depends on several factors, such as the time after injury, the proportion of survivors and nonsurvivors in the study population, and on factors other than tissue hypoxia.

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Cited by 99 publications
(53 citation statements)
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“…Accordingly, the ability to determine which patients will progress to irreversibility is not accurate. With evaluation of laboratory measures such as base deficit and lactate, clinicians can gauge the magnitude of oxygen debt [Moomey 1999] [Abramson 1993] [Rutherford 1992] [Siegel 2003]. However, alone these laboratory measures alone do not accurately predict irreversibility and are not available to medics in the field.…”
Section: Introductionmentioning
confidence: 99%
“…Accordingly, the ability to determine which patients will progress to irreversibility is not accurate. With evaluation of laboratory measures such as base deficit and lactate, clinicians can gauge the magnitude of oxygen debt [Moomey 1999] [Abramson 1993] [Rutherford 1992] [Siegel 2003]. However, alone these laboratory measures alone do not accurately predict irreversibility and are not available to medics in the field.…”
Section: Introductionmentioning
confidence: 99%
“…Quando os tecidos estão em condições de má perfusão, as células, para manterem um nível adequado de energia para o seu metabolismo, entram no ciclo anaeróbico, onde ocorre a utilização do piruvato com conseqüente fornecimento de duas moléculas de ATP e formação do lactato 2,11 . Na literatura, estudos clínicos e experimentais do CH, descrevem que a acidose metabólica decorrente da isquemia tecidual, é a condição responsável pela elevação do nível de LS 9,14,[16][17][18][19][20] .…”
Section: Discussionunclassified
“…A mensuração do LS na prática médica não é um exame rápido e de rotina nos laboratórios na maioria das instituições no atendimento inicial ao politraumatizado, apesar de ser considerado na literatura como um ótimo indicador de estado de choque e de reanimação 9,14,[16][17][18][19][20] .…”
Section: Discussionunclassified
“…Numerosos estudios han establecido el uso del lactato como marcador diagnóstico, terapéutico y pronóstico [11][12][13][14][15][16] . Los niveles de lactato al ingreso están fuertemente asociados a pronóstico 12 , empero, la medición de niveles seriados tiene mayor valor que una medición única aislada 17 .…”
Section: Utilidad De La Medición De Lactato En El Servicio De Urgenciaunclassified