Prognostic Value of BIRC5 in Lung Adenocarcinoma Lacking EGFR, KRAS, and ALK Mutations by Integrated Bioinformatics Analysis

Cao, Yinhe; Zhu, Weikang; Chen, Wanqing; Wu, Jianchun; Hou, Guozhen; Li, Yan

doi:10.1155/2019/5451290

Cited by 40 publications

(36 citation statements)

References 41 publications

(37 reference statements)

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“…After co-expression and correlation analysis using the Oncomine, bc-GenExMiner, and UCSC Xena web-based tools in the present study, we confirmed that CDC20 gene was positively correlated with BIRC5 expression. As a matter of fact, both CDC20 and BIRC5 were found to be co-expressed in lung adenocarcinoma, endometrial cancer, renal cell carcinoma, and thyroid carcinoma [31][32][33][34]. Given that cell cycle process is often coordinated with apoptotic proteins to maintain tissue homeostasis, silencing the expressions of cell cycle protein as well as anti-apoptotic proteins simultaneously could potentially lead to cell cycle arrest and reduce the proliferation of breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Identification of prognostic significance of BIRC5 in breast cancer using integrative bioinformatics analysis

et al. 2020

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Aims: Baculoviral inhibitor of apoptosis repeat containing 5 (BIRC5) plays vital roles in carcinogenesis by influencing cell division and proliferation and by inhibiting apoptosis. However, the prognostic significance of BIRC5 remains unclear in breast cancer. Methods: BIRC5 expression and methylation status were evaluated using the Oncomine and The Cancer Genome Atlas (TCGA) databases. The relevance between BIRC5 and different clinicopathological features as well as survival information was analyzed using the bc-GenExMiner database and Kaplan-Meier Plotter. BIRC5-drug interaction network was obtained using the Comparative Toxicogenomics Database. Results: Based on the results from databases and own hospital data, BIRC5 was higher expressed in different breast cancer subtypes compared with the matched normal individuals. Hormone receptors were negatively correlated with BIRC5 expression, whereas the Scarff-Bloom-Richardson (SBR) grade, Nottingham Prognostic Index (NPI), human epidermal growth factor receptor-2 (HER-2) status, basal-like status, and triple-negative status were positively related to BIRC5 level in breast cancer samples with respect to normal tissues. High BIRC5 expression was responsible for shorter relapse-free survival, worse overall survival, reduced distant metastasis free survival, and increased risk of metastatic relapse event. BIRC5-drug interaction network indicated that several common drugs could modulate BIRC5 expression. Furthermore, a positive correlation between BIRC5 andcell-division cycle protein 20 (CDC20) gene was confirmed. Conclusion: BIRC5 may be adopted as a promising predictive marker and potential therapeutic target in breast cancer. Further large-scale studies are needed to more precisely confirm the value of BIRC5 in treatment of breast cancer.The Breast Cancer Gene-Expression Miner v4.1 (bc-GenExMiner v4.1, http://bcgenex.centregauducheau.fr/BC-GEM), an open access database of published annotated genomics data, was utilized to analyze the relevance between BIRC5 and specific clinicopathological features of breast cancer [16,17]. Association between BIRC5 and metastatic relapse event was assessed using the prognostic module, and correlation of BIRC5 and co-expressed cell-division cycle protein 20 (CDC20) was evaluated using the correlation module. UCSC XenaThe UCSC Xena browser (http://xena.ucsc.edu/) was used to analyze the TCGA Breast Cancer data using the level 3 data. The heatmap and correlation between BIRC5 and CDC20 were then constructed. Kaplan-Meier PlotterThe Kaplan-Meier Plotter (http://kmplot.com/analysis/), a web tool capable to check the effect of 54675 genes on survival using 5143 clinical breast cancer samples, was applied to show the prognostic value of BIRC5 in relapse-free survival, overall survival, and distant metastasis-free survival [18]. The hazard ratio (HR) with 95% confidence interval (CI), and log-rank P-value were calculated automatically.

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Section: Discussionmentioning

confidence: 99%

Identification of prognostic significance of BIRC5 in breast cancer using integrative bioinformatics analysis

et al. 2020

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“…BIRC5 (14.7 kb long) is a mitotic spindle checkpoint gene, present at the telomeric end of chromosome 17. It is a fundamental protein involved in the regulation of mitosis by mediating tumor cell proliferation via β-catenin pathway and tumor cell invasion and migration via TGF-β pathway and PI3K/AKT pathway and apoptosis due to its interaction with DNA damage repair proteins [39] along with several pathological conditions. It has been found to be upregulated in pancreatic cancer, breast cancer, hepatocarcinoma, esophageal carcinoma, and neuroblastoma, with poor clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Unravelling the Role of miR-20b-5p, CCNB1, HMGA2 and E2F7 in Development and Progression of Non-Small Cell Lung Cancer (NSCLC)

Arora

Singh

Rahmani

et al. 2020

Biology

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Lung cancer is a prime cause of worldwide cancer deaths, with non-small cell lung cancer (NSCLC) as a frequent subtype. Surgical resection, chemotherapy are the currently used treatment methods. Delayed detection, poor prognosis, tumor heterogeneity, and chemoresistance make them relatively ineffective. Genomic medicine is a budding aspect of cancer therapeutics, where miRNAs are impressively involved. miRNAs are short ncRNAs that bind to 3’UTR of target mRNA, causing its degradation or translational repression to regulate gene expression. This study aims to identify important miRNA-mRNA-TF interactions in NSCLC using bioinformatics analysis. GEO datasets containing mRNA expression data of NSCLC were used to determine differentially expressed genes (DEGs), and identification of hub genes-BIRC5, CCNB1, KIF11, KIF20A, and KIF4A (all functionally enriched in cell cycle). The FFL network involved, comprised of miR-20b-5p, CCNB1, HMGA2, and E2F7. KM survival analysis determines that these components may be effective prognostic biomarkers and would be a new contemplation in NSCLC therapeutics as they target cell cycle and immunosurveillance mechanisms via HMGA2 and E2F7. They provide survival advantage and evasion of host immune response (via downregulation of cytokines-IL6, IL1R1 and upregulation of chemokines-CXCL13, CXCL14) to NSCLC. The study has provided innovative targets, but further validation is needed to confirm the proposed mechanism.

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“…Previous studies have suggested increased BIRC5 expression contributes to the negative outcomes of various cancers, such as breast, lung, colorectal, prostate, and ovarian cancer [7]. CAO et al [19] found that high BIRC5 expression is related to tumor progression and poor prognosis of lung adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Early Diagnostic and Prognostic Value of BIRC5 in Clear Cell Renal Cell Carcinoma Based on TCGA Data

Wang

Chen

Dang

et al. 2020

Preprint

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Purpose: Clear cell renal cell carcinoma (ccRCC) is a highly lethal cancer that would benefit from non-invasive innovative markers providing early diagnostic and prognostic detection. Increased BIRC5 (baculoviral inhibitor of apoptosis repeat containing 5) expression is associated with negative outcomes or survival in various cancers. Our study aims to investigate the role of BIRC5 of early diagnosis and prognosis in ccRCC by studying the expression of BIRC5 and the correlation between BIRC5 expression and clinicopathological parameters, prognosis in ccRCC. Methods: The BIRC5 expression in ccRCC tissues and normal kidney tissues was measured using the Cancer Genome Atlas (TCGA) database and The Human Protein Atlas database. The correlation between BIRC5 expression and clinicopathological parameters, prognosis in ccRCC was analyzed using UALCAN, Kaplan Meier plotter, GEPIA and SurvExpress. Results: BIRC5 expression is significantly higher in ccRCC than in normal kidney tissues, and is correlated with the clinical stage and pathological grade of ccRCC(P<0.05). The result of analyzing the relationship between BIRC5 expression and outcomes in ccRCC indicates that high BIRC5 expression is an independent prognostic factor affecting overall survival and disease-free survival of ccRCC (P<0.05). Compared with normal kidney tissues, the immunohistochemical test shows that BIRC5 is significantly upregulated in ccRCC tissues. Conclusions: The high expression of BIRC5 is an important indicator of the prognosis of ccRCC, which makes BIRC5 be an effective biomarker for predicting the prognosis of patients in ccRCC. BIRC5 may be a great potential biomarker for early diagnosis of ccRCC.

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Prognostic Value of BIRC5 in Lung Adenocarcinoma Lacking EGFR, KRAS, and ALK Mutations by Integrated Bioinformatics Analysis

Cited by 40 publications

References 41 publications

Identification of prognostic significance of BIRC5 in breast cancer using integrative bioinformatics analysis

Identification of prognostic significance of BIRC5 in breast cancer using integrative bioinformatics analysis

Unravelling the Role of miR-20b-5p, CCNB1, HMGA2 and E2F7 in Development and Progression of Non-Small Cell Lung Cancer (NSCLC)

Early Diagnostic and Prognostic Value of BIRC5 in Clear Cell Renal Cell Carcinoma Based on TCGA Data

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