Prognostic value of basal high-sensitive cardiac troponin levels on mortality in the general population

Abstract

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The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease

“…In the current study the effect of sodium nitrate intake on cardiac biomarkers Hs-TNT, NT-proBNP and CK was investigated. These cardiac biomarkers are known biomarkers for the diagnosis of myocardial injury and heart failure, are associated with increased risk of cardiovascular and all-cause mortality and are known to increase following exercise [52,53]. In the current study we indeed show elevated levels of the cardiac markers after the cycling test, however, the changes were unaffected by sodium nitrate ingestion.…”

Troponins: established and novel indications in the management of cardiovascular disease

“…Now, novel statistical techniques for discrimination of risk and the advent of new biomarkers confer evidence that testing for hsTnT or hsTnI might be useful in the general population to anticipate the risk for incident death, MI or HF 67. A recent meta-analysis including 11 studies, with data on 65 019 participants, explored the relationship between cTnT and cTnI, and cardiovascular and all-cause mortality in the general population 68. The prevalence of detectable hsTnT ranged between 27% and 93% for hsTnT and 75% and 100% for hsTnI, and cTn levels were associated with the incident risk of death in a concentration-dependent manner.…”

Combining High-Sensitivity Cardiac Troponin I and Cardiac Troponin T in the Early Diagnosis of Acute Myocardial Infarction

“…15 Combining 2 signals of cardiomyocyte damage, hs-cTnT and hs-cTnI, might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for AMI with a single blood draw. 11,16,17 Despite differences in biochemical characteristics and release kinetics, 18,19 a recent direct comparison between hs-cTnI and hs-cTnT showed similar, high diagnostic accuracy for AMI, emphasizing the similarities between both isoforms. 12 Based on the observation of an imperfect correlation between blood concentrations of cTnT and cTnI in chronic and acute disorders, 20,21 and in analogy to the quantification of renal function using creatinine and cystatin C, where the combination of 2 parameters associated with the same pathophysiological process but influenced by distinct factors led to a more precise and accurate indicator, 22 we hypothesize that combining hs-cTnI and hs-cTnT concentrations will overcome independent pathophysiological, preanalytical, and analytical differences of the individual molecules, and might therefore have higher diagnostic accuracy for AMI than either hs-cTnI or hs-cTnT alone.…”