Prognostic value of Balkan endemic nephropathy and gender on upper tract urothelial carcinoma outcomes after radical nephroureterectomy: A cohort study

Milojević, Bogomir; Džamić, Zoran; Milojevic, Isidora Grozdic; Bumbaširević, Uroš; Šantrić, Veljko; Kajmaković, Boris; Janicic, Aleksandar; Durutović, Otaš; Dragičević, Dejan; Bojanic, Nebojsa; Radisavcevic, Djordje; Grujičić, Sandra Šipetić

doi:10.1016/j.urolonc.2021.03.016

Cited by 6 publications

(8 citation statements)

References 30 publications

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“…In particular, according to the 2018 Annual Report of the Taiwan Cancer Registry, UTUC comprises up to 40% of all urothelial carcinomas, which is unique compared to other countries. Unlike Western populations [3], the gender distribution of UTUC patients in Taiwan is dominated by women. A multicenter cohort study of 1436 patients from 15 institutions in Taiwan showed that 58% were female [4].…”

Section: Introductionmentioning

confidence: 96%

Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma

Sheng

et al. 2021

Biomedicines

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The importance of blood cell markers in patients with malignant tumors has been studied, but there are few studies on the prognostic value of hemoglobin-to-red cell distribution width ratio (HRR) in cancer. This is the first study to investigate the effect of preoperative HRR on patients with upper tract urothelial carcinoma (UTUC). Our retrospective cohort study included 730 UTUC patients who underwent nephroureterectomy from 2000 to 2019. Clinicopathological parameters were compared according to HRR levels, and the relationship between blood cell markers (HRR, white blood cell [WBC] count, platelet count) and prognosis was evaluated using Kaplan–Meier method and Cox regression model. We found that patients with HRR ≤ 1.05 tended to have worse renal function, higher pathological stages, and more high-grade tumors. In univariate analysis, HRR ≤ 1.05, WBC > 8.65 × 103 cells/μL and platelets >309 × 103 cells/μL were associated with poor progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS). Multivariate analysis demonstrated that HRR ≤ 1.05 and WBC > 8.65 × 103 cells/μL were independent prognostic factors for predicting deterioration of PFS, CSS, and OS. In conclusion, HRR and WBC are easy to obtain in clinical practice and are useful indicators to provide prognostic information before surgery for UTUC.

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Section: Introductionmentioning

confidence: 96%

Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma

Sheng

et al. 2021

Biomedicines

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“…A trend toward a more inferior quality of care for women might be an additional possible cause of the sex inequalities [17]. However, no differences were observed between the sexes in CSS in most studies [4][5][6][7]9].…”

Section: Discussionmentioning

confidence: 99%

“…The worldwide incidence of UTUC is less common in women [3][4][5][6][7]. However, an epidemiological study in Taiwan showed a higher prevalence of UTUC in women than in men [9,11,12,14,15].…”

Section: Discussionmentioning

confidence: 99%

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The Impact of Sex Differences on Renal Function Outcomes After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Retrospective Study

Chien¹,

Li²,

Lu³

et al. 2021

Preprint

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Background: Upper tract urothelial carcinoma (UTUC) is a relatively rare type of urothelial carcinoma. Additionally, only few reports have examined the sex differences in patients with UTUC. Therefore, the present study aimed to identify the sex factors affecting renal function in patients with UTUC.Methods: Patients who underwent radical nephroureterectomy for non-metastatic UTUC between 2000 and 2013 were retrospectively reviewed and divided into two groups by sex. The Kaplan–Meier method was applied to evaluate the effects of sex on survival, whereas for the other clinicopathological parameters, hazard ratios were evaluated using the Cox regression model. The analyses were also performed in patients with different chronic kidney disease (CKD) stages.Results: A total of 368 patients were included, 147 men and 221 women. Female patients had a higher rate of anemia, advanced CKD stage, and dialysis. Male patients predominantly had a higher rate of smoking. The Kaplan–Meier analysis revealed no differences between sexes on metastasis-free survival (MFS) and cancer-specific survival. Multivariate analysis confirmed that ureteral tumors, advanced pathological tumor stage, and adjuvant chemotherapy indicated significantly worse survival outcomes in both sexes. However, only female patients with advanced CKD showed poorer MFS. After adjusting for renal function, the analysis found men had worse MFS.Conclusions: The female sex is significantly associated with a higher prevalence of advanced CKD among patients with UTUC in Taiwan. The impact of sex differences on renal function needs to be considered when evaluating survival.

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“…In bladder cancer, two prior studies identified that gender is an independent risk factor for reduced overall survival 12,13 . However, recently, a cohort study observed that gender cannot be used to predict outcomes, and the 5‐year cancer‐specific survival for male patients was 66.2% when compared to 66.6% for female patients ( p = 0.55) 14 . In colorectal cancer, it was shown that female patients had a significantly longer overall survival than male patients (hazard ratios (HR) 0.78, 95% CI 0.77–0.80), 15 but a meta‐analysis observed that male patients had a better prognosis than female patients (overall survival, HR 0.82, 95% CI 0.68–0.99, p = 0.039) 16 .…”

Section: Introductionmentioning

confidence: 99%

Cancer‐specific survival after diagnosis in men versus women: A pan‐cancer analysis

Yuan

Zeng

et al. 2022

MedComm

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Comprehensive understanding of cancer‐specific survival differences in gender is critical for cancer prevention and treatment. Based on the Surveillance Epidemiology and End Results database, we included data from the most prevalent cancers (lung, esophageal, liver, pancreatic, stomach, colorectal, kidney, and bladder cancer). Cox proportional hazards regression models were constructed to estimate hazard ratios, simultaneously adjusting for demographic, clinical, and treatment factors. Overall, male patients had a worse cancer‐specific survival than female patients. After adjustment for cancer prevalence with 1:1 matching, gender remained a significant factor in cancer‐specific survival. Among the included cancer types, female patients showed survival benefit in lung, liver, colorectal, pancreatic, stomach, and esophageal cancer, and male patients showed better survival in bladder cancer. Except for kidney cancer, the gender disparity was consistent between cancer patients with nonmetastatic and metastatic disease. Overall, gender appears to be a significant factor influencing cancer‐specific survival, and the prognosis of female patients is better than male patients in most cancers. This work might inspire the development of strategies for gender‐specific precision cancer prevention and treatment.

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Prognostic value of Balkan endemic nephropathy and gender on upper tract urothelial carcinoma outcomes after radical nephroureterectomy: A cohort study

Cited by 6 publications

References 30 publications

Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma

Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma

The Impact of Sex Differences on Renal Function Outcomes After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Retrospective Study

Cancer‐specific survival after diagnosis in men versus women: A pan‐cancer analysis

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