Prognostic Value of Background Patterns in the Neonatal EEG

Holmes, Gregory L.; Lombroso, Cesare

doi:10.1097/00004691-199307000-00008

Cited by 250 publications

(142 citation statements)

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“…However, when the state changes were not clearly distinguishable, the recording continued for at least 60 min. Standardized age-dependent criteria (35) were applied to assess EEG background activity, which was scored as:…”

Section: Electrophysiological and Neuroimaging Assessmentmentioning

confidence: 99%

Neonatal seizures and postneonatal epilepsy: a 7-y follow-up study

et al. 2012

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Background: seizures are one of the most common symptoms of acute neurological disorders in newborns. This study aimed at evaluating predictors of epilepsy in newborns with neonatal seizures. Methods: We recruited consecutively 85 neonates with repeated neonatal video-electroencephalogram (eeG)-confirmed seizures between January 1999 and December 2004. The relationship between clinical, eeG, and ultrasound (Us) data in the neonatal period and the development of postneonatal epilepsy was investigated at 7 y of age. results: Fifteen patients (17.6%) developed postneonatal epilepsy. Partial or no response to anticonvulsant therapy (odds ratio (OR) 16.7, 95% confidence interval (cI): 1.8-155.8, P = 0.01; OR 47, 95% cI: 5.2-418.1, P < 0.01, respectively), severely abnormal cerebral Us scan findings (OR: 5.4; 95% cI: 1.1-27.4; P < 0.04), severely abnormal eeG background activity (OR: 9.5; 95% cI: 1.6-54.2; P = 0.01), and the presence of status epilepticus (OR: 6.1; 95% cI: 1.8-20.3; P < 0.01) were found to be predictors of epilepsy. however, only the response to therapy seemed to be an independent predictor of postneonatal epilepsy. conclusion: Neonatal seizures seem to be related to postneonatal epilepsy. Recurrent and prolonged neonatal seizures may act on an epileptogenic substrate, causing further damage, which is responsible for the subsequent clinical expression of epilepsy.

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Section: Electrophysiological and Neuroimaging Assessmentmentioning

confidence: 99%

Neonatal seizures and postneonatal epilepsy: a 7-y follow-up study

et al. 2012

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“…[1][2][3] Thus, determination of etiology is critical, because it gives the opportunity to treat and to make a meaningful statement about the prognosis. [3][4][5] Nowadays, NS is defined by video -electroencephalographic monitoring, by clinical observation associated to ictal or interictal electroencephalogram (EEG), by electrographic discharge without associated clinical manifestation or by neonatal polysomnography 4,[6][7][8][9][10][11][12] . However, in clinical practice at the pediatric or neonatal intensive care units (ICU), in developing countries where synchronized video-EEG monitoring is practically nonexistent, clinical observation becomes the key to the diagnosis 3 .…”

Section: Introductionmentioning

confidence: 99%

Clinicoetiological profile and outcome of neonatal seizures

Sudia

Berwal

Nagaraj

et al. 2015

Int J Contemp Pediatr

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“…15 Douglass et al and Holmes et al, studied burst suppression pattern on EEG among neonates with seizures in two separate studies and found that it is highly predictive for severe deficit on follow up Toso et al also concluded that EEG is a useful tool at the neonatal intensive care unit for predicting poor short-term neurological outcomes for all sick newborn. [16][17][18] In a recent study (2013) on 42 cases with seizure Annu Jose et al tried to co-relate electroencephalogram (EEG), computed tomography (CT), and magnetic resonance imaging (MRI) brain with neurological outcome at 12 months in term neonates. They concluded that a normal EEG and CT brain in a term newborn with hypoxic ischemic encephalopathy (HIE) is associated with good neurological outcome.…”

Section: Discussionmentioning

confidence: 99%