Prognostic value of assessing contact system activation and factor V in systemic inflammatory response syndrome

Pixley, Robin A.; Zellis, S.; Bankes, P.; Cadena, Raul A. DeLa; Page, Jimmy D.; Scott, Cheryl F.; Kappelmayer, János; Wyshock, E G; Kelly, Jamie; Colman, Robert W.

doi:10.1097/00003246-199501000-00010

Cited by 52 publications

(33 citation statements)

References 34 publications

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“…Bradykinin is thought to be a potent inflammatory mediator involved in acute lung injury, ARDS and systemic inflammatory response syndrome (SIRS) that are associated with conditions such as sepsis, immune-mediated lung injury, and multiple trauma [22,23]. BK, consisting of nine amino acids, is a major kinin with welldocumented pharmacological properties including vasodilatation and vascular leakage.…”

Section: Discussionmentioning

confidence: 99%

Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms

Hayashi¹,

Yamashita

Matsui

et al. 2000

Eur Respir J

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Bradykinin (BK) is a major kinin with well-documented pharmacological properties including vascular leakage and induction of a variety of cytokines. However, the intracellular signalling mechanisms by which BK induced proinflammatory cytokine production have not been fully elucidated. This study investigated the role of the extracellular signal-regulated protein kinase 1/2 (ERK 1/2) and p38 mitogen-activated protein kinase (p38 MAPK) in the BK-induced interleukin (IL)-6 and IL-8 production by human lung fibroblasts.Lung fibroblasts were stimulated with BK in the presence or in the absence of PD98059, a specific MAPK/ERK kinase-1 inhibitor, or SB203580, a specific p38 MAPK inhibitor, and IL-6 or IL-8 production and their gene expression was examined. BK-induced ERK 1/2 or p38 MAPK phosphorylation was also analysed by Western blot analysis.BK at nanomolar concentrations stimulated lung fibroblasts to produce IL-6 and IL-8 along with increased ERK 1/2 and p38 MAPK phosphorylation. BK-induced IL-6 and IL-8 synthesis was inhibited by a B2-type BK receptor antagonist. Furthermore, PD98059 or SB203580 significantly suppressed BK-induced IL-6 and IL-8 production and their gene expression.These results indicate that bradykinin-induced interleukin-6 and interleukin-8 production are at least partly mediated through the extracellular signal-related protein kinase 1/2 and p38 mitogen-activated protein kinase pathway-dependent activation in human lung fibroblasts, and suggest that bradykinin appears to be involved in the inflammatory reaction leading to acute lung injury through stimulating interleukin-6 and interleukin-8 production by lung fibroblasts. Eur Respir J 2000; 16: 452±458.

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Section: Discussionmentioning

confidence: 99%

Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms

Hayashi¹,

Yamashita

Matsui

et al. 2000

Eur Respir J

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“…When the system is assembled and activated, H-kininogen is cleaved by activated kallikrein to generate bradykinin, a highly potent proinflammatory peptide. On bacterial surfaces contact activation will result in the cleavage of H-kininogen into two major 45-and 65-kDa fragments (13), and in sepsis low levels of factor XII and intact H-kininogen correlate with a fatal outcome (32). It is therefore noteworthy that H-kininogen is absorbed from plasma by the Sepharose-coupled curli peptides and cleaved into fragments of 45 and 65 kDa (Fig.…”

Section: Resultsmentioning

confidence: 99%

Identification of Two Protein-binding and Functional Regions of Curli, a Surface Organelle and Virulence Determinant ofEscherichia coli

Olsén

Herwald

Wikström

et al. 2002

Journal of Biological Chemistry

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Curli are surface organelles of Escherichia coli. These fibrous proteins, formed by polymerization of a 15-kDa subunit, are expressed by E. coli strains associated with severe infections in humans. A remarkable property of curli is their ability to interact with a wide range of human proteins, interactions that contribute to the enhanced virulence of curli-expressing E. coli. To define the protein-binding region(s) of curli, we investigated the binding properties of overlapping synthetic peptides covering the curli subunit. Two peptides, one covering a 24-amino acid residue sequence in the NH 2 -terminal half of the subunit (NNS24) and one corresponding to the 26 COOH-terminal residues (VDQ26), were found to bind a number of human proteins. Physiochemical analysis revealed that NNS24 adopts a thermally stable ␤-structure, and in solution the peptide forms soluble multimers, predominantly octamers. Intact curli are known to activate the proinflammatory and procoagulant contact system, and when added to human plasma, the NNS24 and VDQ26 peptides induced the release of the potent vasoactive peptide bradykinin. The results map important curli functions to the regions corresponding to the NNS24 and VDQ26 sequences.

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“…In the past two decades, the role of plasma kallikrein-kinin system in experimental and human sepsis (Pixley et al, 1995), and other acute inflammatory states including Rocky Mountains spotted fever (Rao et al, 1988), human experimental endotoxemia (DeLa Cadena et al, 1998), and acute pancreatitis has been well delineated . In 1990s we have developed experimental model of enterocolitis induced by bacterial cell wall polymer peptidoglycanpolysaccharide from group A streptococci (PG -APS) .…”

Section: Plasma Kallikrein -Kinin System In Ibdmentioning

confidence: 99%

Kallikrein – Kinin System and Coagulation System in Inflammatory Bowel Diseases

Stadnicki¹

2011

Ulcerative Colitis - Epidemiology, Pathogenesis and Complications

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Prognostic value of assessing contact system activation and factor V in systemic inflammatory response syndrome

Abstract: Low or persistently low serial factor XII, high-molecular-weight kininogen and factor V values are associated with a poor prognosis, whereas high or increasing values of factor XII, high-molecular-weight kininogen, prekallikrein, and factor V all correlate with a favorable outcome.

Cited by 52 publications

References 34 publications

Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms

Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms

Identification of Two Protein-binding and Functional Regions of Curli, a Surface Organelle and Virulence Determinant ofEscherichia coli

Kallikrein – Kinin System and Coagulation System in Inflammatory Bowel Diseases

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