Prognostic value of age and bone marrow karyotype in 78 adults with acute myelogenous leukemia

Bernard, Philippe; Lacombe, Francis; Dachary, Dominique; David, B.; Boisseau, M. R.; Broustet, A

doi:10.1016/0165-4608(82)90011-5

Cited by 21 publications

(5 citation statements)

References 23 publications

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“…In older patients, the karyotype had no prognostic value. To confirm this result, we have calculated, in another paper, that in a series of 80 AML cases initially studied by Golomb et al (7,13), the same pattern of relationship between age, karyotype and prognosis could be observed (20). Moreover, Sakurai & Sandberg (34) have emphasized that in patients over 70, the survival rates were very poor and did not correlate with the NN, AN or A A karyotype classification.…”

Section: Discussionmentioning

confidence: 57%

“…The response to treatment is indicated only when CR was achieved. For each case, The case numeration corresponds to that of a previous study, where more complete karyotype data can be found (20). Cases 15, 16, 31, 51, 58, 74, and 78 were excluded (cytological review not done).…”

Section: Discussionmentioning

confidence: 99%

“…Among these 78 cases, 71 were reviewed by 3 of us (PB, JF, DD) for cytological classification, according to the FAB cooperative group criteria (18). The cytogenetic and the cytological results have been reported in greater detail elsewhere (19,20).…”

Section: Patientsmentioning

confidence: 99%

“…In order to verify that the patients on whom cytogenetic studies were successful did not present a prognosis different from those in whom karyotypes could not be obtained, we previously studied the survival and the complete remission (CR) rate in a control group: no difference could be found (20).…”

Section: Patientsmentioning

confidence: 99%

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A stage classification for prognosis in adult acute myelogenous leukaemia based upon patients' age, bone marrow karyotype and clinical features

Bernard

Lacombe

Dachary

et al. 1984

Scandinavian Journal of Haematology

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In 71 adult acute myelogenous leukaemia (AML) cases, the relationship between well‐known prognostic features and complete remission (CR) rate and survival was studied. These features were: (i) bone marrow karyotype classified NN, AN, AA according to Sakurai & Sandberg (5); (ii) patients' age; (iii) clinical ‘negative prognostic features' (NPF): previous history of preleukaemia, septicaemia or pneumonia, hyperleucocytosis, associated pathology (diabetes, obesity, renal insufficiency etc.). 59 years of age was found to be a frontier between 2 homogenous groups having quite different prognosis. The NN/AN/AA classification had good prognostic value (CR rate and survival) in patients under 59 years, but not in older patients. In those patients over 59, a significant difference in CR rate and survival appeared between cases with NPF and those without. For each feature having an established relationship to survival, a panel of prognostic points was determined as follows: age over 59 (1 point), AA karyotype in patients under 59 (2 points), NPF in patients over 59 (1 point). Using this stage classification, it was possible to classify every case into 1 of 3 groups (i.e.: 0 points, 1 point, 2 points). The life‐table analysis of these 3 groups showed very significant differences. The median survival times were 18.5 months, 5.2 months and 1.3 month, for the 0‐point group (26 cases), the 1‐point group (19 cases) and the 2‐point group (26 cases), respectively.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

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A stage classification for prognosis in adult acute myelogenous leukaemia based upon patients' age, bone marrow karyotype and clinical features

Bernard

Lacombe

Dachary

et al. 1984

Scandinavian Journal of Haematology

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“…Commonly noted chromosomal abnormalities in patients over age 59 include many associated with poor prognoses such as del(7), del(5q), and trisomy 8 37 , 38 . In an attempt to stratify elderly individuals, patients of ages 59–70 have been analyzed separately from patients over age 70 39 , 40 . When compared in this manner, patients between ages 59–70 have fewer normal karyotypes (35%–40%) although the spectrum of abnormalities is similar to that of patients under age 50.…”

Section: Frequently Associated Clonal Chromosomal Abnormalitiesmentioning

confidence: 99%

Acute Myelogenous Leukemia in the Elderly

Ballester¹,

Moscinski²,

Morris³

et al. 1992

J American Geriatrics Society

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Relationship between patients' age, bone marrow karyotype, and outcome of induction therapy in acute myelogenous leukemia

Bernard¹,

Lacombe²,

Reiffers³

et al. 1985

American J Hematol

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Bone marrow karyotypes were performed in 88 cases of adult acute myelogenous leukemia (AML) at diagnosis and classified NN (normal), AA (abnormal), and AN (mixture of normal and abnormal metaphases). A clear relationship was found between karyotype and complete remission (CR) rate: 58% CR in (NN + AN) cases; 14% CR in AA cases (P less than .009). This relationship was even stronger when only patients under 60 years of age were studied. Considering failures of induction treatment, no relationship was found between the NN/AN/AA classification and a drug resistance. In patients over 60, the worse prognosis could be explained by an inferior ability to tolerate intensive treatment.

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Prognostic value of age and bone marrow karyotype in 78 adults with acute myelogenous leukemia

Cited by 21 publications

References 23 publications

A stage classification for prognosis in adult acute myelogenous leukaemia based upon patients' age, bone marrow karyotype and clinical features

A stage classification for prognosis in adult acute myelogenous leukaemia based upon patients' age, bone marrow karyotype and clinical features

Acute Myelogenous Leukemia in the Elderly

Relationship between patients' age, bone marrow karyotype, and outcome of induction therapy in acute myelogenous leukemia

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