Prognostic value of added stratification of circumferential resection margin status in oesophageal carcinoma

Abstract

Both RCPath and CAP criteria to define CRM have similar prognostic value. A novel three-tier classification of CRM status provides more detailed prognostication.

Meta‐analysis of the influence of a positive circumferential resection margin in oesophageal cancer

“…It is increasingly recognized that adenocarcinoma and SCC of the oesophagus are completely different disease entities with differing risk factors, treatment options, genetic basis and prognosis, and should therefore be analysed separately 49 . Although reporting in the additional papers improved over time, mixed analyses of different histological types of malignancy, without reporting of the effect of either subgroup on prognosis, is still commonplace 14,38,39,42 . A subgroup analysis was conducted in the present study, but this was limited by the lack of separate reporting by histological type in each paper.…”

“…Khan et al 21 Roh et al 22 Griffiths et al 23 Sujendran et al 24 Saha et al 27 Deeter et al 25 Scheepers et al 26 Sillah et al 28 Pultrum et al 30 Mirnezami et al 29 Chao et al 31 Verhage et al 32 Rao et al 34 0 Harvin et al 33 Reid et al 35 Theologou et al 14 O'Neill et al 37 Salih et al 36 Ahmad et al 38 O'Farrell et al 13 Lee et al 40 Okada et al 41 Ghadban et al 42 Quinn et al 15 Knight et al 44 Heterogeneity: τ 2 = 0•07; χ 2 = 82•97, 25 d.f., P < 0•001; I 2 = 70% Total Test for overall effect: Z = 8•06, P < 0•001…”

“…Analysis of the 26 studies reporting univariable survival analyses, using the RCP definition, found OS to be shorter Deeter et al 25 Pultrum et al 30 Verhage et al 32 Chao et al 31 Ahmad et al 38 Salih et al 36 O'Farrell et al 13 O'Neill et al 37 Gilbert et al 39 Lee et al 40 Okada et al 41 Ghadban et al 42 Knight et al 44 Quinn et al 15 1 HR, hazard ratio.…”

“…Sujendran et al 24 Thompson et al 8 Saha et al 27 Scheepers et al 26 Mirnezami et al 29 Reid et al 35 Ahmad et al 38 Theologou et al 14 Okada et al 41 Depypere et al 43 Knight et al 44 Quinn et al 15 An inverse-variance random-effects model was used for meta-analysis. Hazard ratios (HRs) are shown with 95 per cent confidence intervals.…”

“…CRM−/+, negative/positive circumferential resection margin; RCP, Royal College of Pathologists. Verhage et al 32 Ahmad et al 38 Gilbert et al 39 Okada et al 41 Depypere et al 43 Knight et al 44 Quinn et al 15 Test for overall effect: Z = 4•30, P < 0•001…”