Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma

Zaky, Amen H.; Elsers, Dalia A.; Bakry, Rania; Abdel-Wanis, Mostafa E.; Nabih, Ola; Hafez, Rania; Rezk, Mahmoud

doi:10.1007/s12253-019-00674-5

Cited by 3 publications

(4 citation statements)

References 45 publications

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“…Likewise, p53 was found in the interaction networks of PTPN5 and the chemotherapy drugs cisplatin and doxorubicin. p53 is a tumor suppressor protein; however, mutant p53 protein has been shown to be a biomarker in several cancers, such as human breast cancer, colorectal cancer, ovarian cancer, oesophageal squamous cell carcinoma, non-small cell lung cancer, and a prognostic marker in breast cancer, oesophageal squamous cell carcinoma, colon cancer, non-small cell lung cancer and B cell lymphoma [26][27][28][29][30][31][32][33]. In human head and neck squamous cell carcinoma, p53 mutation played an important role in tumorigenesis and progression.…”

Section: Discussionmentioning

confidence: 99%

In-gel digestion coupled with mass spectrometry (GeLC-MS/MS)-based salivary proteomic profiling of canine oral tumors

et al. 2020

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Background Various types of oral tumors, either benign or malignant, are commonly found in dogs. Since saliva directly contacts the tumors and saliva collection is non-invasive, easily accessible and cost effective, salivary biomarkers are practical to be used for the diagnosis and/or prognosis of these diseases. However, there is limited knowledge of protein expression in saliva for canine oral tumors. The present study aimed to investigate novel biomarkers from the salivary proteome of dogs with early- and late-stage oral melanoma (EOM and LOM, respectively), oral squamous cell carcinoma (OSCC), benign oral tumors (BN), and periodontitis and healthy controls (CP), using an in-gel digestion coupled with mass spectrometry (GeLC-MS/MS). The relationships between protein candidates and chemotherapy drugs were explored and the expression of potential biomarkers in saliva and tissues was verified by western blot analysis. Results For saliva samples, increased expression of protein tyrosine phosphatase non-receptor type 5 (PTPN5) was shown in all tumor groups compared with the CP group. Marked expression of PTPN5 was also observed in LOM and OSCC compared with that in BN and EOM. In addition, tumor protein p53 (p53), which appeared in the PTPN5–drug interactions, was exhibited to be expressed in all tumor groups compared with that in the CP group. For tissue samples, increased expression of p53 was shown in LOM compared with the control group. Conclusion PTPN5 and p53 were proposed to be potential salivary biomarkers of canine oral tumors.

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Section: Discussionmentioning

confidence: 99%

In-gel digestion coupled with mass spectrometry (GeLC-MS/MS)-based salivary proteomic profiling of canine oral tumors

et al. 2020

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“…In formula (16), s(B) represents the calculation formula of the sampling function for the sample variable, which also needs to meet some conditions. e expression formula of the conditions is as follows:…”

Section: Principles Of Adaptive Samplingmentioning

confidence: 99%

“…e purpose of this discussion on the clinicopathological characteristics of lymphoma and its efficacy is to conduct a statistical study on a large number of existing cases. In this way, the medical effect and medical decision-making assistance for this type of diseases lacking more critical information can be carried out [16]. e principle of sampling is to extract some samples from a large data sample set.…”

Section: Introduction and Applications Of Bayesian Algorithmsmentioning

confidence: 99%

Clinicopathological Characteristics and Curative Effect of Lymphoma Based on Sampling Theory

Ding

2022

Mathematical Problems in Engineering

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With the continuous development of society, people’s attention to the body is also increasing. This article explains and analyzes the clinicopathological characteristics of a more serious disease, lymphoma, and the effect of treatment. In the previous studies of this type of disease, the collected data was very limited, and the theory for data analysis was also lacking. The direct result was that the analysis of such disease types was not complete, and it was difficult to obtain statistical significance, which made the clinical guidance weak. In order to improve this problem, this paper applies the sampling theory in statistics to the clinicopathological characteristics of lymphoma and the effect of treatment. Through the scientific analysis of such samples, it is hoped to provide some ideas for clinical treatment. In the sampling theory, this paper selects two methods, Bayesian algorithm and adaptive sampling theory, and introduces the corresponding methods for the correlation analysis of the clinicopathological characteristics and curative effect of lymphoma according to the above two methods. These related processing methods start from a large number of samples and provide sufficient computational support for the final experiments. Experiments show that the score of clinical symptoms of lymphoma is not less than 96%, which means that the patient is in a state of recovery. When the evaluation score is between 63% and 96%, the corresponding treatment has a significant effect. These results show that, in the analysis of the clinicopathological characteristics of lymphoma and related treatment effects, by using the Bayesian algorithm in the sampling theory and the adaptive sampling theory, the data results can well correspond to the clinical effects.

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“…Kim et al (26) and Shannon-Lowe et al(27) They achieved similar results, and they stated that EBV positive HL patients were signi cantly associated with poorer clinical, pathological, and prognostic parameters than EBV negative HL patients.Mestre et al and Zaky et al proved that COX-2 expression is associated with poor clinicopathological parameters(42,43). In study by Ohno et al, COX-2 expression was inversely related to the apoptotic index.…”

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confidence: 97%

EBV promotes tumorigenicity and worsens the prognosis of Hodgkin lymphoma through the expression of survival enhancing proteins by activating the JAK / STAT and NF-kB signaling pathways. (A comparative study between EBV positive and negative Hodgkin lymphoma)

Alabiad

Balata

et al. 2022

Preprint

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Background Epstein-Barr virus (EBV) is involved in 40% of all Hodgkin's lymphoma (HL) cases. EBV produces epigenetic alterations in the host genome that decrease the expression of proapoptotic proteins and activate the expression of survival immortalization genes. Methods According to EBNA-1 detection by nested PCR, 64 patients with HL were classified into two groups: EBV positive and negative HL. The expression levels of JAK/STAT and NF-kB pathway mRNA molecules (JAK2, STAT1, IRF-1, PD-L1, IFN-, NFkB, Bcl-xL, and COX-2) by both RT-PCR and qRT-PCR, and the results proteins PD-L1, Bcl-xL, and COX-2 by immunohistochemistry were analyzed and correlated with each other, Results Positive mRNA expression of either (JAK/STAT) or (NF-kB) pathways: (JAK2, STAT1, IRF-1, and PD-L1) and (IFN-, NFkB, Bcl-xL, COX-2) respectively are highly significantly correlated with each other (p 0.001) and with EBV positive HL patients (p 0.001). EBV positive HL cases had a higher incidence of relapse (p = 0.008), poor DFS (p = 0.013), higher mortality (p = 0.015), and low OS rates (p 0.028) Conclusion EBV in HL promotes the expression of survival immortalization signals by activating the JAK/STAT and NF-kB pathways and is associated with poor clinicopathological criteria, a higher incidence of disease progression, relapse, and poor overall survival. Therefore, targeting the JAK/STAT and NF-kB pathway members could be valuable in the management of EBV-associated Hodgkin's Lymphoma cases.

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Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma

Cited by 3 publications

References 45 publications

In-gel digestion coupled with mass spectrometry (GeLC-MS/MS)-based salivary proteomic profiling of canine oral tumors

In-gel digestion coupled with mass spectrometry (GeLC-MS/MS)-based salivary proteomic profiling of canine oral tumors

Clinicopathological Characteristics and Curative Effect of Lymphoma Based on Sampling Theory

EBV promotes tumorigenicity and worsens the prognosis of Hodgkin lymphoma through the expression of survival enhancing proteins by activating the JAK / STAT and NF-kB signaling pathways. (A comparative study between EBV positive and negative Hodgkin lymphoma)

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