Prognostic value of a three-grade classification in primary epithelial parotid carcinoma: Result of a histological review from a 20-year experience of total parotidectomy with neck dissection in a single institution

Jouzdani, E; Yachouh, Jacques; Costes, Valérie; Faillie, Jean Luc; Cartier, C.; Poizat, Flora; Pierre, G.; Burcia, Vincent; Makeïeff, M.; Crampette, L.; Guerrier, B.; Garrel, R.

doi:10.1016/j.ejca.2009.10.012

Cited by 38 publications

(28 citation statements)

References 18 publications

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“…Squamoid variants of MECs were thoroughly sorted out (Schwarz et al , 2011). Grading was based on a three-tiered grading system (Therkildsen et al , 1998; Jouzdani et al , 2010). The ACCC, BCAC, EMC, CAC and PLGA were considered low grade (G1) with the exception of dedifferentiated tumours, which were classified high grade (G3).…”

Section: Methodsmentioning

confidence: 99%

Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

et al. 2012

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Background:Activity of the tumour-suppressor gene PTEN is reduced in different types of cancer and implicates non-responsiveness to targeted therapy. This study evaluates the gene and protein status of PTEN in salivary gland carcinomas.Methods:A total of 287 carcinomas of the major and minor salivary glands were investigated for phosphatase and tensin homologue located on chromosome 10 (PTEN) deletion and loss of PTEN expression using fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC), respectively. Results were correlated to clinicopathological parameters, long-term survival, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) (IHC and FISH) status of the tumours.Results:Hemizygous deletions of PTEN were found in 35 out of 232 (15.1%) carcinomas, while homozygous deletions were observed in 17 out of 232 (7.3%) tumours. Phosphatase and tensin homologue located on chromosome 10 deletion was common in certain histological subtypes and especially homozygous deletion was associated with high-grade malignancy, lymph node metastases and unfavourable long-term prognosis (P<0.001). Loss of PTEN expression was present in 59 out of 273 (21.6%) carcinomas and was significantly correlated to genomic PTEN deletion, high-grade malignancy (P<0.001), increased tumour size (P=0.036), lymph node metastases (P=0.007) and worse disease-specific survival (P=0.002). Genomic PTEN deletion, in particular homogenous deletion (P<0.001) predominantly occurred in tumours with increased gene copy number of EGFR (60.0%) and/or amplification of HER2 (63.6%). Loss of PTEN expression was frequently found in tumours overexpressing EGFR (28.6%) and/or HER2 (52.6%).Conclusion:PTEN function is reduced in different types of salivary gland cancer indicating unfavourable prognosis. Its association with EGFR and HER2 signalling might affect targeted therapy.

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Section: Methodsmentioning

confidence: 99%

Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

et al. 2012

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“…All tumors were classified according the contemporary World Health Organization's classification of salivary gland tumors [1]. Grading was based on a 3-tiered grading system as recently described (Table 1) [17,18]. The 33 cases of carcinoma ex pleomorphic adenoma were classified and graded according to the malignant component of the tumor.…”

Section: Histology and Classificationmentioning

confidence: 99%

EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis

Ettl¹,

Stiegler²,

Zeitler³

et al. 2012

Human Pathology

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“…A number of clinical and pathological prognostic characteristics have been identified in PGCs, including histological grade, T stage, N stage, and facial nerve infiltration. Other features such as age, lymphovascular invasion at the primary tumor site, and surgical margin status are less–well‐established prognostic factors as a consequence of inconsistent findings across different studies, likely due to the intrinsic heterogeneity and the relatively low incidence of PGCs …”

Section: Introductionmentioning

confidence: 99%

Implications of intraglandular lymph node metastases in primary carcinomas of the parotid gland

et al. 2015

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Prognostic value of a three-grade classification in primary epithelial parotid carcinoma: Result of a histological review from a 20-year experience of total parotidectomy with neck dissection in a single institution

Cited by 38 publications

References 18 publications

Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis

Implications of intraglandular lymph node metastases in primary carcinomas of the parotid gland

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