Prognostic Value of 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography/Computed Tomography after Autologous Hematopoietic Stem Cell Transplantation in Lymphoma Using Deauville Scores

Abstract

Purpose. In the present study, we mainly aimed to evaluate the prognostic value of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]F-FDG) positron emission tomography (PET)/computed tomography (CT) after autologous stem cell transplantation (ASCT) in lymphoma. Procedures. A total of 76 lymphoma patients who benefited from [18F]F-FDG PET-CT (within 3 months and 3–6 months) after ASCT in our institution between April 2010 and December 2019 were enrolled in this retrospective study. These abovementioned patients were divided into two groups based on the Deauville criteria. The Kaplan–Meier method was used in survival analysis, and the log-rank method was adopted in comparison. Prognostic factor analysis was performed by the Cox regression model. Results. Positive post-ASCT [18F]F-FDG PET-CT was associated with lower progression-free survival (PFS) and overall survival (OS) ( p = 0.001 and p = 0.022, respectively). Univariate analysis showed the post-ASCT PET-CT result was the only independent factor associated with PFS ( p = 0.002). Both the number of previous treatments and post-ASCT PET-CT result had a different impact on OS ( p = 0.040 and p = 0.028, respectively). Multivariate analysis showed the post-ASCT PET-CT result was the only independent factor associated with OS ( p = 0.028). The results showed no significant change from the abovementioned results when DS < 3 was defined as the negative result. For patients who had a PET-CT scan within 3–6 months after ASCT, the negative PET-CT group had a better prognosis including PFS and OS ( p = 0.009 and p = 0.025, respectively). However, among the patients receiving PET-CT within 3 months, the result was not statistically significant ( p = 0.064 and p = 0.445, respectively). Conclusion. Collectively, we found that the post-ASCT [18F]F-FDG PET-CT was a strong indicator for PFS and OS, and a time window of 3–6 months was appropriate for post-ASCT [18F]F-FDG PET-CT. Trial registration number: ChiCTR2100042745.

PET/CT Evaluation of the Effect of Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of T‐Cell Lymphoblastic Lymphoma

“…us, 18 F-FDG PET/CT is able to detect various body responses to this treatment during allogeneic hematopoietic stem cell transplantation treatment and facilitate further clinical treatment. Dai et al [32] used the improved 18 F-FDG PET/CT technique to evaluate the prognosis after stem cell transplantation, and found that the improved 18 F-FDG PET/ CT technique had a high application value in predicting PFS and OS in patients after stem cell transplantation treatment, especially in patients after 3 to 6 months of treatment. However, some experts proposed that for patients with relapsed or refractory T-lymphocytic lymphoma, 18 F-FDG PET/CT is used to predict the treatment prognosis after HSCT [33].…”

“…Reference [31] e sensitivity of FLT-PET/CT was lower than that of FDG-PET/CT e uptake of 18F-FDG in tumor tissue was higher than that of 18 F-FLT Reference [32] ASCT 18 F-FDG positivity after PET-CT was associated with lower PFS and OS; PET-CT outcome was the only independent factor associated with OS (p � 0.028); PET within 3-6 months after ASCT-In patients with CT scan, the PFS and OS prognosis were better in the PET-CT negative group 18 F-FDG PET/CT technology had high application value in predicting PFS and OS of patients after stem cell transplantation (especially the 3-6 months window period) Reference [33] PET/CT after HSCT (post-PET) was associated with PFS (P � 0.030). However, none of the assessed factors predicted OS.…”

Analysis of Positive Results of 18F-FDG PET/CT Imaging after Hematopoietic Stem Cell Transplantation in Lymphoma

“…Moreover, 2-deoxy-2-[ 18 F]fluoro-D-glucose positron emission tomography/computed tomography ( 18 F-FDG PET-CT) has been widely used for staging, restaging, aggressiveness evaluation, and response monitoring of lymphoma since PET-CT was incorporated into the guidelines for lymphoma in 2007 [ 6 , 7 ]. Our preliminary studies [ 8 , 9 ] have shown that post-transplantation PET is helpful for the prognostic assessment of lymphoma patients.…”