Prognostic value of 18F-FET PET/CT in newly diagnosed WHO 2016 high-grade glioma

Abstract

O-(2-[18F]fluoroethyl)-l-tyrosine positron-emission tomography/computed tomography (18F-FET PET/CT) is well known in brain tumor management. Our study aimed to identify the prognostic value of 18F-FET PET/CT in high-grade gliomas (HGG) according the current 2016 World Health Organization (WHO) classification. Patients with histologically proven WHO 2016 HGG were prospectively included. A dynamic 18F-FET PET/CT was performed allowing to obtain 2 static PET frames (static frame 1: 20–40 minutes and static frame 2: 2–22 minutes). We analyzed static parameters (standard uptake value [SUV]max, SUVmean, SUVpeak, TBRmax, TBRmean, tumoral lesion glycolysis, and metabolic tumoral volume) for various isocontours (from 10% to 90%). PET parameters, clinical features, and molecular biomarkers were compared with progression-free survival (PFS) and overall survival (OS) in univariate and multivariate analysis. Twenty-nine patients were included (grade III n = 3, grade IV n = 26). Mean PFS and OS were, respectively, 8.8 and 13.9 months. According to univariate analysis, SUVmean, SUVpeak, TBRmax, and TBRmean were significantly correlated with OS. In static 1 analysis, TBRmax seemed to be the best OS prognostic parameter (P = .004). In static 2 analysis, TBRmean was the best parameter (P = .01). In static 1 analysis, only SUVpeak was significant (P = .05) for PFS. Good performance status (PS < 2; P < .0001) and extent of resection (P = .019) identified the subgroup of patients with the best OS. Only TBRmax (P = .026) and extent of resection (P = .025) remained significant parameters in multivariate analysis. Our data suggested that high TBRmax seemed to be the most significant OS independent prognostic factor in patients with newly diagnosed HGG.

68Ga-PSMA-11 PET/CT Imaging in Brain Gliomas and Its Correlation With Clinicopathological Prognostic Parameters

“…21 Other publications suggested that FET PET/CT is a useful noninvasive tool for prognosis of brain tumors. [22][23][24] There was no false-positive case in our study for PSMA PET. However, there was 1 patient with grade III oligodendroglioma whose lesion did not show significant PSMA uptake (patient 8).…”

“…MET and O -(2-[ 18 F] fluoroethyl)-l-tyrosine FET PET are superior to FDG in terms of sensitivity for identifying glioma grade 21 . Other publications suggested that FET PET/CT is a useful noninvasive tool for prognosis of brain tumors 22–24 …”

<p>miR-383 Down-Regulates the Oncogene CIP2A to Influence Glioma Proliferation and Invasion</p>

“…The pathological differentiation based on the WHO classification system. 9 Forty-two pairs of gliomas and adjacent para-carcinoma tissue samples were collected between January 2018 and December 2019. These tissues were instantly placed into liquid nitrogen to protect RNA integrity and stored at −80°C for further analysis.…”

Correlation between rCBV Delineation Similarity and Overall Survival in a Prospective Cohort of High-Grade Gliomas Patients: The Hidden Value of Multimodal MRI?

“…Dynamic susceptibility contrast brain MRI evaluates several aspects of brain vasculature by assessing different parameters such as relative cerebral blood volume (rCBV) and permeability. It could provide additional information compared to conventional MRI [7] to allow a more robust characterization of the peritumoral area. Moreover, diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps illustrate restricted diffusion of water molecules in the cellular microenvironment [8].…”