Prognostic value of 1,5-anhydro-d-glucitol incorporating syntax score in acute coronary syndrome

Morishita, Tetsuji; Uzui, Hiroyasu; Mitsuke, Yasuhiko; Tada, Hiroshi

doi:10.1007/s00380-022-02126-8

Cited by 1 publication

(1 citation statement)

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“…The receptors for these cells can be activated by binding to chemokines produced at the site of inflammation, secretion of various pro-inflammatory factors, and enhancement of the local inflammatory response. In addition, 1,5-AG may also be involved in endothelial dysfunction [ 33 ]. Monitoring of 1,5-AG levels could therefore be useful for determining the risk of coronary plaque rupture at an early stage.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Serum 1,5-anhydroglucitol Levels in Patients with Acute Myocardial Infarction

Wang¹,

Yang²,

Zhang³

et al. 2022

Rev. Cardiovasc. Med.

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Background: Diabetes mellitus is a major risk element for cardiovascular disease. In the present study we investigated whether 1,5anhydroglucitol (1,5-AG), a new marker for glucose monitoring, can predict patient outcome following acute myocardial infarction (AMI). Methods: A total of 270 AMI patients who underwent coronary angiography (CAG) at Beijing Hospital from March 2017 to 2020 were enrolled in this prospective cohort study. The serum 1,5-AG concentration and biochemical indicators were evaluated prior to CAG. Cox regression analysis was used to investigate the relationship between 1,5-AG levels and major adverse cardiovascular and cerebrovascular events (MACCEs), and with all-cause mortality. Results: During the median follow-up period of 44 months, 49 MACCEs occurred and 33 patients died. The 1,5-AG level was significantly lower in the MACCEs group than in the MACCEs-free group (p = 0.001). Kaplan-Meier analysis also revealed that low 1,5-AG levels were associated with MACCEs (p < 0.001) and with all-cause mortality (p = 0.001). Multivariate analysis showed that low 1,5-AG (≤8.8 µg/mL) was an independent predictor of MACCEs (hazard ratio (HR) 2.000, 95% confidence interval (CI): 1.047-3.821, p = 0.036). However, 1,5-AG was not a significant predictor for all-cause mortality in AMI patients (p > 0.05). Conclusions: Low 1,5-AG levels can predict MACCEs in AMI patients, but not all-cause mortality. Clinical Trial Registration: NCT03072797

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Section: Discussionmentioning

confidence: 99%