Prognostic utility of the chest computed tomography severity score for the requirement of mechanical ventilation and mortality in hospitalized patients with COVID-19

Kimura, Yukiyoshi; Cristancho-Rojas, César; Kimura-Sandoval, Yumi; Tapia-Sosa, R.; Guerrero‐Torres, Lorena; Licano-Zubiate, Mariana; Chapa-Ibargüengoitia, Mónica

doi:10.1016/j.heliyon.2023.e16020

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…Therefore, not only geographical differences reflecting heterogenicity in demographic and clinical characteristics of patients (5), but also the pandemic waves are an important factor which may have an impact on patient prognosis. For these reasons, prognostic scores (including clinical variables, radiological features and biomarkers) that were elaborated in the previous waves (35)(36)(37)(38)(39)(40) may change their accuracy across different pandemic waves and should be re-evaluated in the current epidemiological scenario.…”

Section: Figurementioning

confidence: 99%

Evolution of in-hospital patient characteristics and predictors of death in the COVID-19 pandemic across four waves: are they moving targets with implications for patient care?

Trecarichi,

Olivadese,

Davoli

et al. 2024

Front. Public Health

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ObjectivesThe aim of this work was to study characteristics, outcomes and predictors of all-cause death in inpatients with SARS-CoV-2 infection across the pandemic waves in one large teaching hospital in Italy to optimize disease management.MethodsAll patients with SARS-CoV-2 infection admitted to our center from March 2020 to June 2022 were included in this retrospective observational cohort study. Both descriptive and regression tree analyses were applied to identify factors influencing all-cause mortality.Results527 patients were included in the study (65.3% with moderate and 34.7% with severe COVID-19). Significant evolutions of patient characteristics were found, and mortality increased in the last wave with respect to the third wave notwithstanding vaccination. Regression tree analysis showed that in-patients with severe COVID-19 had the greatest mortality across all waves, especially the older adults, while prognosis depended on the pandemic waves in patients with moderate COVID-19: during the first wave, dyspnea was the main predictor, while chronic kidney disease emerged as determinant factor afterwards.ConclusionPatients with severe COVID-19, especially the older adults during all waves, as well as those with moderate COVID-19 and concomitant chronic kidney disease during the most recent waves require more attention for monitoring and care. Therefore, our study drives attention towards the importance of co-morbidities and their clinical impact in patients with COVID-19 admitted to hospital, indicating that the healthcare system should adapt to the evolving features of the epidemic.

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