Prognostic Usefulness of Serum Acid Phosphatase Levels in carcinoma of the Prostate

Ishibe, Tomoyuki; Usui, Tsuguru; Nihira, Hiromi

doi:10.1016/s0022-5347(17)59696-2

Cited by 19 publications

(8 citation statements)

References 5 publications

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“…The response of acid phosphatase activity to endo crine therapy has been demonstrated by Ischibe et al [3] in 1973. They showed that a diminution of acid phospha tase activity after hormonal treatment is associated with a significantly more favorable short-term prognosis than found in the absence of such a response.…”

Section: Commentmentioning

confidence: 89%

Unusual Presentation of Metastatic Carcinoma of Prostate

et al. 1986

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Section: Commentmentioning

confidence: 89%

Unusual Presentation of Metastatic Carcinoma of Prostate

et al. 1986

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“…In addition, there may be elevations secondary to transrectal and transurethral manipulation of the prostate. Nevertheless, as previously noted, the PAP level has prognostic significance after hormonal treatment in patients with metastatic prostatic cancer [40]. More recently, progress has been made in the development of more sensitive assays, using immunochemical techniques.…”

Section: Diagnosismentioning

confidence: 89%

“…The natural history of a stage C lesion, particularly one causing obstructive symptoms, is more predictable, with a life expectancy of two to three years in an untreated patient [38]. Factors associated with decreased survival include diagnosis in patients less than 60 years old [37, 391, poorly differentiated cancers [21, 241, large tumor bulk or high stage at the time of diagnosis, failure of hormonal therapy to lower the serum acid phosphatase [40], metastatic disease in the proximal femurs or lymphangitic spread in the lungs [41], and impaired immunologic reactivity in patients with endocrine-resistant tumors [42].…”

Section: Natural Historymentioning

confidence: 99%

Overview of past and current philosophy of prostatic cancer

1980

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Carcinoma of the prostate is the second most common cancer in men, yet no significant change in overall survival has occurred since the original description of the results of castration by Huggins and Hodges. Many important questions about the disease remain unanswered. The cause of prostatic cancer is unknown, and few specific environmental or viral agents have been linked with the tumor. Increased recognition of the importance of frequent digitial rectal examination has resulted in more tumors being diagnosed in early stages. Developments in sonography suggest that it may be useful in detecting the presence of prostatic cancer and whether extraprostatic extension has occurred. Recent inprovements in the sensitivity of prostatic acid phosphatase assays have been made, but their use as a screening tool remains limited. In patients with clinical stage B lesions that are microscopically confined to the prostate, treatment by radical prostatectomy appears to confer greatest survival. The exact role of radiotherapy remains to be defined. However, when the tumor extends beyond the prostate and is localized to the pelvis, external beam ro interstitial radiation is appropriate. Pelvic lymphadenectomy has significant morbidity, but less invasive methods of pelvic nodal evaluation are less accurate. Lymphadenectomy has not been shown to have any therapeutic effect. Whether hormonal therapy improves survival needs further investigation, and efforts must continue to develop means of predicting hormonal responsiveness. Those patients unlikely to respond to hormonal therapy should be treated with early chemotherapy.

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“…In the investigation of prostatic cancer, three important items of information can be obtained by estimation of serum acid phosphatase isowere obtained by differential centrifugation, but zymes, namely: ( 1 ) the hormonal activity of the tissue (8,9,12,13,21,26); (2) the re sponse to antihormonal treatment (6,7,13,22,23,30), and (3) the stage of tumor growth (10,14,17). In routine clinical investigations of cancer, elevated L(+)-tartrate-inhibitable acid phosphatase activity in serum is a useful in dicator of advanced cancer ( 1,14,22).…”

Section: Introductionmentioning

confidence: 99%

“…In routine clinical investigations of cancer, elevated L(+)-tartrate-inhibitable acid phosphatase activity in serum is a useful in dicator of advanced cancer ( 1,14,22).…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Electrophoretic Properties of Acid Phosphatase Isozymes and Their Distribution in Cell Functions from Neoplastic Prostatic Tissues

Fischer¹,

Gevers²

1980

Urol Int

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The various acid phosphatase isozymes can be distinguished on the basis of their biochemical properties or their net electrical charge. Four main groups of isozymes hydrolyze β-glycerophosphate: the fastest-moving form seemed to be related to the cancerous state. The quantity of enzyme, either in the whole homogenate or in cytoplasmic fractions was not a useful criteria for cancer, however, while the distribution of acid phosphatase in subcellular structures was characteristic in cancer cases. Cell fractions were obtained by differential centrifugation, but were contaminated with prostatic secretions.

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Prognostic Usefulness of Serum Acid Phosphatase Levels in carcinoma of the Prostate

Cited by 19 publications

References 5 publications

Unusual Presentation of Metastatic Carcinoma of Prostate

Unusual Presentation of Metastatic Carcinoma of Prostate

Overview of past and current philosophy of prostatic cancer

Biochemical and Electrophoretic Properties of Acid Phosphatase Isozymes and Their Distribution in Cell Functions from Neoplastic Prostatic Tissues

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