Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Abstract

All editorial decisions for this article, including selection of reviewers and the final decision, were made by guest editor Alberto Cuocolo, MD.

Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease: J-ACCESS 4 study

“…Short axis, vertical long-axis, and horizontal long-axis views were generated on MP images using a standard processing protocol that was verified by the J-ACCESS study [10][11][12]. All reconstructed short-axis data created at each site were sent to the J-ACCESS site (Osaka, Japan) in Digital Imaging and Communication in Medicine (DICOM) format.…”

Prognostic Risk Stratification of Cardiac Events Evaluated by Aortic Calcification in Elderly Patients with Chronic Kidney Disease

“…At any rate, their involvement with patients with an eGFR<50 ml/min/1.73 m 2 has not been reported. In the J-ACCESS 3 study examining patients with an eGFR<50 ml/min/1.73 m 2 , a lower eGFR, a higher CRP, and a higher SSS using MPI was a strong predictor of prognosis in CKD patients (6). Based on the J-ACCESS study, SSS was also the most useful predictor for cardiac events in the Japanese population (12)(13)(14).…”

“…Study by Quantitative Gated SPECT (J-ACCESS 3) is a multicenter, prospective cohort study investigating the ability of MPI to predict cardiac events in 529 patients with CKD but without definitive CAD (5,6). In this study, a sum of the myocardial perfusion defect scores at stress (SSS) >8, estimated glomerular filtration rate (eGFR) <15 ml/min/1.73 m 2 , and a C-reactive protein (CRP) >0.3 (mg/dl) were associated with major cardiac events in CKD patients.…”

“…The principal design of the J-ACCESS 3 study was previously described (5,6 showing aortic calcification in CXR. The aortic calcification was visually assessed using CXR (11).…”

“…The authors wish to thank the physicians and technologists participating in this study listed elsewhere (6), and the J-ACCESS office staff for implementing the study. We also thank Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.…”