Prognostic significance of β-catenin expression in patients with ovarian cancer: A meta-analysis

Long, Hui-Deng; Li, Ganxiong; Wen, Xiaoman; Lv, Yanmin; Zhang, Min; Wei, Yuanfeng; Xie, Wenting; Zhong, Peng; Pang, Lijuan

doi:10.1016/j.gene.2018.08.047

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…In addition, NGF stimulation increases the expression of VEGF and the transcription factor c-MYC in EOC cells and explants from EOC biopsies [ 8 , 10 ]. NGF/TRKA signalling (via PI3K/AKT and MAPK/ERK pathways) increases the expression of oncoproteins such as survivin and β-catenin, in cancer cells [ 11 , 12 , 13 , 14 , 15 ], and these two proteins are also upregulated in EOC [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells

Garrido

Salvatierra

Valenzuela-Valderrama

et al. 2020

Pharmaceuticals

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Epithelial ovarian cancer (EOC) is a lethal gynaecological neoplasm characterized by rapid growth and angiogenesis. Nerve growth factor (NGF) and its high affinity receptor tropomyosin receptor kinase A (TRKA) contribute to EOC progression by increasing the expression of c-MYC, survivin and vascular endothelial growth factor (VEGF) along with a decrease in microRNAs (miR) 23b and 145. We previously reported that metformin prevents NGF-induced proliferation and angiogenic potential of EOC cells. In this study, we sought to obtain a better understanding of the mechanism(s) by which metformin blocks these NGF-induced effects in EOC cells. Human ovarian surface epithelial (HOSE) and EOC (A2780/SKOV3) cells were stimulated with NGF and/or metformin to assess the expression of c-MYC, β-catenin, survivin and VEGF and the abundance of the tumor suppressor miRs 23b and 145. Metformin decreased the NGF-induced transcriptional activity of MYC and β-catenin/T-cell factor/lymphoid enhancer-binding factor (TCF-Lef), as well as the expression of c-MYC, survivin and VEGF in EOC cells, while it increased miR-23b and miR-145 levels. The preliminary analysis of ovarian biopsies from women users or non-users of metformin was consistent with these in vitro results. Our observations shed light on the mechanisms by which metformin may suppress tumour growth in EOC and suggest that metformin should be considered as a possible complementary therapy in EOC treatment.

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Section: Introductionmentioning

confidence: 99%

Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells

Garrido

Salvatierra

Valenzuela-Valderrama

et al. 2020

Pharmaceuticals

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“…The high preoperative serum level of Creatinine was associated with poor survival, which indicated that it might be an additional independent prognostic parameter in patients with epithelial OC [14]. Nucleus and/or cytoplasm of β-catenin expression might be associated with tumor progression and subsequently represent a predictive factor of poor prognosis in OC patients [15]. Wilms' tumor 1 (WT1), an antigen target, was a biomarker for poor prognosis, particularly when combined with altered p53 in OC [16].…”

Section: Discussionmentioning

confidence: 99%

Survival-associated transcriptome analysis in ovarian cancer

Xu¹,

Zhou²,

Wang³

et al. 2020

EJGO

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Purpose of investigation: Ovarian Cancer (OC) is one of the most lethal gynecologic cancers worldwide. Despite the standard treatment, including radical resection, systemic chemotherapy, and targeted drugs for patients, survival rates remain low. This study provides new ideas for the diagnosis and treatment of Ovarian Cancer. Material and Methods: We performed Kaplan-Meier analysis on the transcriptome of Ovarian Cancer based on RNA-Seq data from The Cancer Genome Atlas (TCGA). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) enrichment were used for pathway and functional enrichment. Protein-protein interaction (PPI) network was constructed and visualized by SRING and Cytoscape. Results: A total of 1693 genes associated with survival were identified. The Kyoto Encyclopedia of Genes and Genomes pathway and Gene Ontology enrichment analysis revealed that these selected genes were differently enriched in numerous functional pathways. The top ten hub genes (RIPK4, HSPA8, FOS, STAT1, CD40LG, FGF2, RAC1, CXCR4, PRPF19, and CXCL10) were identified in our PPI network. Three highly connected cluster modules were differently enriched in several functional pathways. Conclusion: These key biomarkers in Ovarian Cancer may have diagnostic and therapeutic value in the future.

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“…Cancer is a group of diseases that originate in human epithelial tissue and is the most common type of malignancy. 1 Chemotherapy and radiotherapy are commonly used in traditional cancer treatment. 2,3 These treatments can inhibit the growth of tumors to some extent, but can also cause systemic toxicity, resistance tolerance and other defects.…”

Section: Introductionmentioning

confidence: 99%

Construction of novel multifunctional luminescent nanoparticles based on DNA bridging and their inhibitory effect on tumor growth

Pan

Zhang

et al. 2019

RSC Adv.

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Prognostic significance of β-catenin expression in patients with ovarian cancer: A meta-analysis

Cited by 5 publications

References 24 publications

Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells

Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells

Survival-associated transcriptome analysis in ovarian cancer

Construction of novel multifunctional luminescent nanoparticles based on DNA bridging and their inhibitory effect on tumor growth

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