Prognostic significance of VEGF immunohistochemical expression and tumor angiogenesis in head and neck squamous cell carcinoma

Kyzas, Panayiotis; Stefanou, Dimitrios; Batistatou, Anna; Agnantis, Niki J.

doi:10.1007/s00432-005-0003-6

Cited by 93 publications

(77 citation statements)

References 50 publications

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“…A similar finding was reported in a retrospective series by Kyzas et al, in which VEGF-positive phenotype was associated with higher clinical stage and worse overall survival. 28 As expected, higher T classification (T2) in our study also predicted a relative risk of about 1.5 times that of T1 stage for poorer local disease control (P <.05) and poorer 5-year overall survival (P <.05). Several other studies have demonstrated similar outcomes for higher T-classification laryngeal disease.…”

Section: Discussionsupporting

confidence: 86%

Prognostic significance of vascular endothelial growth factor protein levels in T1‐2 N0 laryngeal cancer treated with primary radiation therapy

Yang¹,

Haffty²

2006

Cancer

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BACKGROUND.The purpose of this study was to assess the prognostic value of vascular endothelial growth factor protein levels in a large cohort of patients with T1‐T2 N0 laryngeal cancer treated with primary radiation therapy (XRT).METHODS.Primary tumor specimens from a cohort of 123 patients with T1‐T2 N0 laryngeal cancer treated with XRT between 1975 and 2000 were constructed into a tissue microarray. Clinical prognostic factors included age, sex, T classification, and tumor subsite. Molecular prognostic factors included vascular endothelial growth factor, epidermal growth factor receptor, and p53 expression, determined by using immunohistochemistry on tissue microarrays. The association between vascular endothelial growth factor status, covariables, and outcome was assessed.RESULTS.With a median follow‐up of 9.9 years, 32 (26%) were diagnosed with local relapse (5‐year local relapse‐free rate, 70.4%). T2 tumor stage (31.7%) was a significant predictor of local relapse (relative risk [RR], 1.71; 95% confidence interval [CI], 1.21–2.43; P<.05). Positive expression of vascular endothelial growth factor, epidermal growth factor receptor, and p53 were: 8.5%, 58.7%, and 36.4%, respectively. In univariate analysis, vascular endothelial growth factor positivity was a significant predictor of overall survival (RR = 1.62; 95% CI, 0.99–2.42; P = .05). In multivariate analysis, positive vascular endothelial growth factor status maintained significant correlation with overall survival (RR, 2.79; 95% CI, 1.49–4.95; P = .002).CONCLUSIONS.Vascular endothelial growth factor positivity appeared to be a significant predictor of overall survival in a multivariate model. Further evaluation of vascular endothelial growth factor‐positive laryngeal cancers treated with primary XRT is warranted. Cancer 2007;109:566–573. © 2006 American Cancer Society.

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Section: Discussionsupporting

confidence: 86%

Prognostic significance of vascular endothelial growth factor protein levels in T1‐2 N0 laryngeal cancer treated with primary radiation therapy

Yang¹,

Haffty²

2006

Cancer

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“…VEGF is known as a multifunctional cytokine that plays a critical role in blood vessel formation including both vasculogenesis and angiogenesis [26]. VEGF promotes the induction of endothelial cell proliferation and capillary morphogenesis both in a paracrine mode, after its release by other cells, and in an autocrine manner in VEGF-producing endothelial cells [27]. In fact, the over-expression of VEGF has been regarded as a major factor underlying pathological angiogenesis in cancer, as well as in chronic inflammation, such as psoriasis [28].…”

Section: Discussionmentioning

confidence: 99%

Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation

Shubbar

Vegfors

Carlström

et al. 2011

Breast Cancer Res Treat

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Psoriasin (S100A7), originally identified in psoriasis, is a calcium-binding protein belonging to the multigenic S100 family. In high-grade ductal carcinoma in situ (DCIS), psoriasin was identified as one of the most abundant transcripts. We have previously shown that psoriasin was induced by reactive oxygen species (ROS). Moreover, the downregulation of psoriasin by short hairpin RNA (shRNA) led to the reduced expression of VEGF and inhibited tumour Our data suggest that psoriasin expression in mammary epithelial cells leads to increased endothelial cell proliferation in a paracrine manner through RAGE. Psoriasin may therefore play a role in breast cancer progression by promoting oxidative stress response and angiogenesis.

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“…In addition to the EGFR-PI3K pathway, molecular alterations in other intracellular signaling pathways have been observed in patients with SCCHN, including, but not limited to, janus kinase/ signal transducers and activators of transcription, mitogenactivated protein kinase (MAPK), NOTCH [39], VEGF [78], MET [79], and IGF [79]. Recently, inhibition of poly ADP ribose polymerase [81] and S100A4 signaling pathways have also been suggested as possible new target strategies for SCCHN [82].…”

Section: Blocking Pi3k Pathway and Other Pathways Concurrentlymentioning

confidence: 99%

Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck

2015

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Prognostic significance of VEGF immunohistochemical expression and tumor angiogenesis in head and neck squamous cell carcinoma

Abstract: Vascular endothelial growth factor expression may have prognostic significance for patients with HNSCC.

Cited by 93 publications

References 50 publications

Prognostic significance of vascular endothelial growth factor protein levels in T1‐2 N0 laryngeal cancer treated with primary radiation therapy

Prognostic significance of vascular endothelial growth factor protein levels in T1‐2 N0 laryngeal cancer treated with primary radiation therapy

Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation

Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck

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