Prognostic significance of tumor laterality in advanced ovarian cancer

Abstract

This study aimed to investigate the effect of incorporating tumor laterality into the International Federation of Gynecology and Obstetrics (FIGO) staging system for advanced ovarian cancer. MethodsThe clinical data of 131 patients with advanced ovarian cancer treated between 2008 and 2018 were retrospectively reviewed. To investigate the prognostic significance of tumor laterality, we divided the patients into unilateral and bilateral groups. The prognostic significance of tumor laterality (bilateral vs. unilateral) was evaluated using univariate and multivariate analyses. The effect of incorporating tumor laterality into the FIGO staging system to predict survival outcomes was evaluated using the Kaplan-Meier method. ResultsBoth overall survival (OS) and progression-free survival (PFS) were longer in the unilateral group than in the bilateral group. Multivariate analysis demonstrated that tumor laterality was an independent predictor of OS (hazard ratio, 1.75; confidence interval, 1.05 to 2.92; P=0.032). In patients with stage III disease, the bilateral group had a shorter OS than the unilateral group, but it was comparable to the OS in stage IV patients (P=0.354).The incorporation of tumor laterality into the FIGO staging system improved the stratification of survival probabilities. ConclusionTumor laterality can be an independent prognostic factor in patients with advanced ovarian cancer. The incorporation of tumor laterality may improve the predictive performance of the FIGO staging system in patients with advanced ovarian cancer.

Prognostic Outcome of Mesenchymal Transition Biomarkers in Correlation with EGFR Expression in Epithelial Ovarian Carcinoma Patients

“…This finding matched the study by Momenimovahed et al, (2019) and Badmann et al, (2020), with 70% of cases typed as serous neoplasm (Momenimovahed et al, 2019;Badmann et al, 2020). On the other hand, Yamada et al, (2021) study demonstrated less incidence of serous neoplasm was 52% of total cases and 40% of unilateral ovarian cancer. Sixty-five percent of cases in our study were presented at FIGO stage III.…”

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“…Asymmetries in morphology and function in the left and right adrenals may lead to a higher incidence of unilateral adrenal adenomas on the left side compared to the right. In cancers of other paired organs, including the breast, kidney, and ovary, similar lateralizing asymmetries were also observed, leading scientists to consider laterality as an independent prognostic factor in these cancers [36][37][38].…”

CHARACTERISTIC OF CT SCAN IN MUCINOUS OVARIAN TUMOR Retrospective Study in Dr. Soetomo General Academic Hospital Surabaya January 2020 – July 2023

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