Prognostic Significance of Time-delay to Peak Creatine Kinase After Direct Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients

Katayama, Toshiro; Nakashima, Hiroshi; Takagi, Chisa; Honda, Yukiharu; Suzuki, Shin; Iwasaki, Yoshihiro; Yamamoto, Tadashi; Yoshioka, Masato; Yano, Katsusuke

doi:10.1536/ihj.46.771

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Furthermore, our study also revealed that after adjustment with covariates, hypoalbuminemia interacted with covariates and failed to independently predict in-hospital adverse outcomes. Killip class II-IV has been consistently established as an independent predictor in previous reports, 21,22) and was also observed in our study population. We evaluated the presence of adverse outcomes from the beginning of hospital admission, which was the same time as Killip class determination.…”

Section: Discussionsupporting

confidence: 88%

Low Serum Albumin Levels and In-Hospital Adverse Outcomes in Acute Coronary Syndrome

2010

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SummaryEpidemiological studies have demonstrated an association between low serum albumin levels and coronary heart disease and mortality. Nevertheless, the impact of a low serum albumin level during acute coronary syndrome has not yet been established. The aim of the present study was to investigate whether low serum albumin levels are associated with adverse outcomes in acute coronary syndrome. We enrolled 82 consecutive patients with acute coronary syndrome from whom venous blood for serum albumin measurement was drawn immediately upon hospital admission. Thirty-five patients had a low albumin level (hypoalbuminemia) and 47 had a normal albumin level (normoalbuminemia). In-hospital adverse outcomes (death, acute heart failure, cardiogenic shock, and reinfarction) were recorded during hospitalization in the intensive coronary care unit. The results of our study showed that the incidence of in-hospital adverse outcomes was 43%, with death occurring in 8 patients (10%). In-hospital adverse outcomes occurred more frequently in patients presenting with hypoalbuminemia, whereas mortality did not differ significantly. Univariate analysis showed that hypoalbuminemia was associated with a 2.8-fold greater risk of developing adverse outcomes. This risk was greater in the subgroup of NSTEACS (5.4-fold increased risk), but not in those with STEMI. Adjustment with other covariates revealed that hypoalbuminemia did not predict independently in-hospital adverse outcomes. It interacted with other predictors, especially Killip class II-IV, which was consistently an independent predictor of in-hospital adverse outcomes. (Int Heart J 2010; 51: 221-226)

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Section: Discussionsupporting

confidence: 88%

Low Serum Albumin Levels and In-Hospital Adverse Outcomes in Acute Coronary Syndrome

2010

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“…Previously, we reported that the time delay to peak-CK after primary PCI in AMI patients had a close relation to damage to the microvascular circulation. 26) In other words, AMI patients who are smokers might have less damage to the microvascular circulation compared with nonsmokers.…”

Section: Discussionmentioning

confidence: 99%

<b>The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

Katayama¹,

Iwasaki²,

Sakoda³

et al. 2008

Int. Heart J.

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SUMMARYDespite increased risk for coronary artery disease and acute myocardial infarction (AMI), prior studies have found that smokers with AMI have lower mortality rates than nonsmokers, a phenomenon often termed 'smoker's paradox'. The present study was designed to examine the etiology of 'smoker's paradox', especially with respect to the association with inflammation.The subjects included 528 consecutive AMI patients who were admitted within 24 hours of onset and underwent successful coronary intervention. Of the 528 subjects, 232 (44%) were smokers.The cardiac mortality rates over a 6 month period was significantly lower in the smoking group than the nonsmoking group (3% versus 9%, P = 0.01). There were significantly more male patients in the smoking group, and the smoking group was significantly younger than the nonsmoking group (P < 0.0001). The value of high sensitivity C-reactive protein (hs-CRP) on admission and 24 hours after onset, and serum amyloid A protein (SAA) were significantly higher, and acute phase BNP was significantly lower (hs-CRP on admission 1.36 ± 1.03 mg/dL versus 0.75 ± 0.82 mg/dL, P = 0.02, hs-CRP at 24 hours 3.86 ± 4.32 mg/dL versus 2.90 ± 3.46 mg/dL, P = 0.008, SAA; 288 ± 392 µg/dL versus 176 ± 206 µg/dL, P < 0.05, BNP; 248 ± 342 pg/mL versus 444 ± 496 pg/mL, P = 0.0002) in the smoking group than in the nonsmoking group. The early ST-segment resolution rate was higher in the smoking group compared with the nonsmoking group (80% versus 66%, P = 0.003).The reason why smokers with AMI have lower mortality rates than nonsmokers, the so-called 'smoker's paradox', is believed to be because smoking induces inflammation and smokers may have less damage to microvascular function after primary percutaneous coronary intervention. (Int Heart J 2008; 49: 13-24) Key words: Myocardial infarction, Smoking, Inflammation EVEN though many epidemiologic studies have shown that cigarette smoking is associated with higher rates of myocardial infarction and death from coronary From the

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“…Patients between 18 and 80 years of age were eligible for inclusion in the study if they had a first acute ST-elevation myocardial infarction with occlusion of the proximal left anterior descending (LAD) coronary artery and a creatine kinase (CK) level >1,000 IU, which was successfully treated by percutaneous coronary intervention (PCI) within 24 h. According to previous observations, 28,29 CK values were serially measured every 4 h for 24 h after the onset of AMI. Exclusion criteria were the presence of cardiogenic shock requiring intravenous pressors or intra-aortic balloon counterpulsation, pulmonary edema, advanced hepatic or renal dysfunction, evidence of malignant diseases, or unwillingness to participate.…”

Section: Patients and Study Protocolmentioning

confidence: 99%

Intracoronary Transplantation of Non-Expanded Peripheral Blood-Derived Mononuclear Cells Promotes Improvement of Cardiac Function in Patients With Acute Myocardial Infarction

Tatsumi

Ashihara

Yasui

et al. 2007

Circ J

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ifferentiation of mesodermal cells to angioblasts and subsequent endothelial differentiation was believed to exclusively occur in embryonic development, 1 but this dogma was overturned when human adult peripheral blood mononuclear cells (PBMNCs) were demonstrated to differentiate into the endothelial lineage. 2 These cells named "endothelial progenitor cells" (EPCs) expressed endothelial markers, and were incorporated into Circulation Journal Vol.71, August 2007 the sites of ischemia. 3,4 We have recently demonstrated that bone marrow mononuclear cells (BMMNCs) contain EPCs in the CD34 + cell fraction and various proangiogenic factors, such as basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and angiopoietin 1 in the CD34 -cell fraction, and that implantation of BMMNCs into the site of ischemia enhances angiogenesis via harmonic supply of EPCs and angiogenic factors. 5,6 This technique has been used clinically and developed as a useful therapeutic option for human critical limb ischemia. 7 The concept of the heart as an organ composed of terminally differentiated myocytes incapable of regeneration is also being challenged. [8][9][10] Although attempts to replace necrotic tissue by transplanting other cells (eg, fetal cardiac myocytes or skeletal myoblasts) succeeded in reconstituting heart muscle, these cells failed to completely integrate structurally and to display characteristic physiological function. [11][12][13] In contrast, bone marrow cells (BMCs) have the ability to differentiate into various tissue and are likely to Circ J 2007; 71: 1199 -1207 (Received January 17, 2007 revised manuscript received March 28, 2007; accepted April 24, 2007 Background Transplantation of non-expanded peripheral blood mononuclear cells (PBMNCs) enhances neovessel formation in ischemic myocardium and limbs by releasing angiogenic factors. This study was designed to examine whether intracoronary transplantation of PBMNCs improves cardiac function after acute myocardial infarction (AMI). Methods and ResultsAfter successful percutaneous coronary intervention (PCI) for a ST-elevation AMI with occlusion of proximal left anterior descending coronary artery within 24 h, patients were assigned to either a control group or the PBMNC group that received intracoronary infusion of PBMNCs within 5 days after PCI. PBMNCs were obtained from patients by COBE spectra-apheresis and concentrated to 10 ml, 3.3 ml of which was infused via over-the-wire catheter. The primary endpoint was the global left ventricular ejection fraction (LVEF) change from baseline to 6 months' follow-up. The data showed that the absolute increase in LVEF was 7.4% in the control group and 13.4% (p=0.037 vs control) in the PBMNC group. Cell therapy resulted in a greater tendency of ∆Regional ejection fraction (EF) or significant improvement in the wall motion score index and Tc-99m-tetrofosmin perfusion defect score associated with the infarct area, compared with controls. Moreover, intracoronary administration of PBMNCs did not ex...

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Prognostic Significance of Time-delay to Peak Creatine Kinase After Direct Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients

Cited by 5 publications

References 23 publications

Low Serum Albumin Levels and In-Hospital Adverse Outcomes in Acute Coronary Syndrome

Low Serum Albumin Levels and In-Hospital Adverse Outcomes in Acute Coronary Syndrome

<b>The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

Intracoronary Transplantation of Non-Expanded Peripheral Blood-Derived Mononuclear Cells Promotes Improvement of Cardiac Function in Patients With Acute Myocardial Infarction

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Prognostic Significance of Time-delay to Peak Creatine Kinase After Direct Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients

Cited by 5 publications

References 23 publications

Low Serum Albumin Levels and In-Hospital Adverse Outcomes in Acute Coronary Syndrome

Low Serum Albumin Levels and In-Hospital Adverse Outcomes in Acute Coronary Syndrome

<b>The Etiology of &lsquo;Smoker&rsquo;s Paradox&rsquo; in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>

Intracoronary Transplantation of Non-Expanded Peripheral Blood-Derived Mononuclear Cells Promotes Improvement of Cardiac Function in Patients With Acute Myocardial Infarction

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<b>The Etiology of ‘Smoker’s Paradox’ in Acute Myocardial Infarction With Special Emphasis on the Association With Inflammation</b>