Prognostic Significance of Thyroid Gland Involvement in Laryngeal Carcinoma

Gilbert, Ralph W.; Cullen, Roberto; Nostrand, A. W. P. Van; Bryce, Douglas P.; Harwood, Andrew R.

doi:10.1001/archotol.1986.03780080056012

Cited by 38 publications

(55 citation statements)

References 9 publications

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“…Other investigators have found that necrotic tumors have been associated with increased incidence of lymph node metastases (27). Large tumors are often ulcerated, edematous with fixation or markedly reduced mobility.…”

Section: Tumor Necrosismentioning

confidence: 99%

See 1 more Smart Citation

Laryngectomy whole organ serial sections Histological Parameters Correlated with Recurrence Rate

Vermund¹,

Krajči²,

Eide³

et al. 2004

Acta Oncologica

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Section: Tumor Necrosismentioning

confidence: 99%

“…However, radiation fibrosis as the sole cause of fixation has not been observed in serial sections (26). With increasing degree of cord fixation, the local recurrence rate has increased (27).…”

Section: Tumor Infiltration Of Laryngeal Musclesmentioning

confidence: 99%

Laryngectomy whole organ serial sections Histological Parameters Correlated with Recurrence Rate

Vermund¹,

Krajči²,

Eide³

et al. 2004

Acta Oncologica

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“…In their study, Gilbert noted that the survival in this group of patients was poor, with 18 patients dying of their diseases within 3 years [15].…”

Section: Discussionmentioning

confidence: 95%

The Role of Thyroidectomy in Advanced Laryngeal and Pharyngolaryngeal Carcinoma

Dequanter

Shahla

Paulus

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Total thyroidectomy or hemithyroidectomy together with a total laryngectomy (TL) or pharyngo laryngectomy (TPL) for (pharyngo) laryngeal cancer often renders the patient hypothyroid and commits them to life-long thyroid hormone replacement. To determine the incidence of thyroid gland invasion (TG) in patients undergoing TL or TPL with total thyroidectomy (TThy) or lobectomy (HThy) for advanced laryngeal or hypo pharyngeal cancer and to assess predicative factors. Retrospective analysis of 35 patients from 2007 to 2010. Specimens were examined to determine the incidence of TG invasion and relevant predicative factors such as histological grade and subglottic extension. Pre-operative imaging was reviewed to assess for radiological evidence of TG invasion. TL and TThy was performed in 13 patients. TL and HThy was performed in four patients and TPL and TThy was performed in 18 patients. Surgery was performed for primary and recurrent cancer in 29 and six patients, respectively. Histological evidence of invasion of the TG was found in three patients. Relationship was found between TG invasion and subsite of primary carcinoma and the presence of subglottic extension. No relationship was found between TG invasion and patient's sex, stage of primary disease at surgery, degree of differentiation. In addition, no significant relationship was found between the presence of TG invasion and recurrent disease. Invasion of the TG in patients undergoing a TL or TPL is a rare event and limits the need for a TTHy in most cases.

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“…6,7 Patients with positive resection margins and thyroid gland involvement were also excluded, as such cases are known to have a poor prognosis. [8][9][10] The 104 patients studied therefore represent a highly selected group of patients with locally advanced laryngeal carcinoma.…”

Section: Discussionmentioning

confidence: 99%