Prognostic significance of the tumor suppressor protein p53 gene in childhood acute lymphoblastic leukemia

Abstract

The tumor suppressor protein p53 (TP53) gene is associated with various types of cancer; however, little is known about TP53 expression in patients with childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the prognostic value of TP53 expression in childhood ALL. To achieve this, TP53 mRNA levels of 146 children with ALL and 23 child donors with idiopathic thrombocytopenic purpura were determined by reverse transcription-quantitative PCR. Relapse-free survival (RFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. The results demonstrated that TP53 mRNA level in patients with ALL was higher compared with that in the ITP donors (P=0.019). Patients with highly-expressed TP53 exhibited lower percentages of peripheral blood blast, higher platelet counts and inferior complete remission rates compared with patients with low expression of TP53. Survival analyses revealed that high TP53 expression was associated with poor OS and RFS in childhood ALL (P=0.018 and P=0.028, respectively) and was an independent prognostic factor in multivariate analysis for poor RFS (P<0.001) and OS (P<0.001). In conclusion, high TP53 expression is associated with poor outcomes and may be used as a molecular prognostic marker to be incorporated into an improved risk classification system for childhood ALL.

Identification of a Seven-lncRNA-mRNA Signature for Recurrence and Prognostic Prediction in Relapsed Acute Lymphoblastic Leukemia Based on WGCNA and LASSO Analyses

“…Patients with highly expressed MK harbored poor OS ( p = 0.022) and relapse-free survival (RFS, p = 0.047) compared with patients with low expression of MK. Weng et al [ 10 ] found that the mRNA level of the TP53 gene was significantly higher in patients with ALL than controls. Multivariate analysis revealed that highly expressed TP53 was an independent factor for the prediction of poor OS and RFS ( p < 0.001).…”

Aptamer-Functionalized Three-Dimensional Carbon Nanowebs for Ultrasensitive and Free-Standing PDGF Biosensor

“…Recently, the sensing of tumor-producing proteins and biomarkers associated with cancer has been focused because of their inherent role in diagnosing diseases. − In particular, platelet-induced growth factors (PDGFs), which are a dimeric glycoprotein composed of two A components (PDGF-AA), two B components (PDGF-BB), or one of each (PDGF-AB), have emerged as crucial cancer biomarkers of diseases such as atherosclerosis, pulmonary hypertension, organ fibrosis, tumorigenesis, and balloon-injury-induced restenosis. − Among the divergent PDGFs, PDGF-BB is considered as a latent biomolecule for cancer recognition because it is associated with malignant tumors in humans . To detect PDGF-BB, studies were conducted using different sensing principles such as surface plasmon resonance, fluorescence, and electrochemical redox reactions. − Among them, the most common method for detecting PDGF-BB is the fluorescence technique, which utilizes changes in fluorescence intensity through energy transfer between fluorophore-labeled aptamer and target analyte.…”