Prognostic significance of the ratio of surgically resected to radiologically detected lung nodules in patients with metastatic osteosarcoma

Ahmed, Gehad; Elshafiey, Maged M.; Romeih, Marwa; El-Gammal, Ahmed; Kamel, Ayman H.; Salama, Asmaa; Farid, Nesma; Zaky, Iman

doi:10.1016/j.suronc.2021.101701

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…However, this cohort of patients were therapy‐naïve with micronodules that likely responded to standard primary systemic therapies compared to those with relapse or progressive pulmonary disease that persisted after multiple systemic therapies. In contrast, Ahmed et al performed a retrospective study in 125 patients with metastatic OST (48 with initial lung metastases at diagnosis and 77 with delayed lung metastases), and reported that patients with high ratio (>1) of surgically resected (SR) to radiologically detected (RD) OST pulmonary nodules (SR/RD) were associated with poor survival compared to patients with low ratio of SR/RD 34 . They proposed that the poor survival among patients with high ratio of SR/RD may have had unresected subclinical lung disease, inferring that the presence of unresected micronodules conferred a poor prognosis 34 …”

Section: Discussionmentioning

confidence: 99%

“…In contrast, Ahmed et al performed a retrospective study in 125 patients with metastatic OST (48 with initial lung metastases at diagnosis and 77 with delayed lung metastases), and reported that patients with high ratio (>1) of surgically resected (SR) to radiologically detected (RD) OST pulmonary nodules (SR/RD) were associated with poor survival compared to patients with low ratio of SR/RD. 34 They proposed that the poor survival among patients with high ratio of SR/RD may have had unresected subclinical lung disease, inferring that the presence of unresected micronodules conferred a poor prognosis. 34 Studies assessing the impact of different PM approaches in OST are lacking.…”

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confidence: 99%

“…34 They proposed that the poor survival among patients with high ratio of SR/RD may have had unresected subclinical lung disease, inferring that the presence of unresected micronodules conferred a poor prognosis. 34 Studies assessing the impact of different PM approaches in OST are lacking. Importantly, our study reports comparable survival outcomes between thoracotomy versus thoracoscopy versus CTT at initial metastasectomy and at first pulmonary relapse or progression.…”

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confidence: 99%

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Survival outcomes and surgical morbidity based on surgical approach to pulmonary metastasectomy in pediatric, adolescent and young adult patients with osteosarcoma

Kuo,

Malvar,

Chi

et al. 2023

Cancer Medicine

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BackgroundThoracotomy is considered the standard surgical approach for the management of pulmonary metastases in osteosarcoma (OST). Several studies have identified the advantages of a thoracoscopic approach, however, the clinical significance of thoracotomy compared to thoracoscopy is yet to be evaluated in a randomized trial.AimsThe primary aim was to determine the survival outcomes in OST patients based on surgical approach for pulmonary metastasectomy (PM) and secondary aim was to assess the post‐operative morbidities of OST PM through various surgical approaches.Materials and MethodsWe conducted a single institution retrospective study to compare survival outcomes and surgical morbidity according to the surgical approach of the management of pulmonary metastases in patients with OST.ResultsSixty‐one patients with OST underwent PM. Twenty‐one patients were metastatic at diagnosis and underwent PM during primary treatment; nine had thoracotomy, six thoracoscopy, and six combined thoracoscopy with thoracotomy (CTT). Forty‐three patients with first pulmonary relapse or progression underwent PM; 18 had thoracotomy, 16 thoracoscopy and nine CTT. There was no difference in survival between surgical approaches. There were significantly more postoperative morbidities associated with thoracotomy for initial PM (pain and postoperative chest tube placement), and for PM at first relapse (pneumothoraces, pain, Foley catheter use and prolonged hospitalizations).ConclusionOur study demonstrates that patients with OST pulmonary metastases have comparable poor outcomes despite varying surgical approaches for PM. There were significantly more postoperative morbidities associated with thoracotomy for PM. Surgical bias and other competing risks could not be assessed given the limitations of a retrospective study and may be addressed in a prospective trial evaluating surgical approach for PM in OST.

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confidence: 99%

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confidence: 99%

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Survival outcomes and surgical morbidity based on surgical approach to pulmonary metastasectomy in pediatric, adolescent and young adult patients with osteosarcoma

Kuo,

Malvar,

Chi

et al. 2023

Cancer Medicine

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“…The prognostic significance of the proportion of radiologically detectable to surgically deleted osteosarcoma lung nodules (SR/RD) was examined by Ahmed et al (21) . Researchers analyzed data from 125 individuals who had metastasectomy for metastatic osteosarcoma.…”

Section: Related Workmentioning

confidence: 99%

Advancements in Image Enhancement and Attention based efficientdet Optimization Classifier for Precise Osteosarcoma Lung Nodule Detection

Nandhini,

Sengaliappan

2024

Salud, Ciencia y Tecnología - Serie de Conferencias

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Introduction: Osteosarcoma is a malignant bone tumor that frequently spreads to the lungs, hence therapy effectiveness depends on early identification. However, noise and subtle characteristics still pose a challenge for reliable Lung Nodules Detection (LND) in medical pictures. In earlier work, SSD-VGG16 was implemented to provide a bounding box with an accuracy score that represented a single osteosarcoma nodule. Increasing model complexity is sometimes necessary to achieve improved accuracy with current approaches, which might worsen their computing inefficiencies.Methods: For accurate osteosarcoma lung nodule identification, this study offers the hybrid Dynamic Virtual Bats Algorithm with Attention based Efficient Object identification (A- EfficientDet). In order to improve the quality and informativeness of clinical pictures, this study suggests including Chebyshev filtering into the pre-processing pipeline. It focuses on CT scans for the purpose of detecting lung nodules associated with osteosarcoma. Additionally, provide the optimized A-EfficientDet model, a hybrid EfficientDet model improved using the DVBA optimization technique for accurate lung nodule identification. Results: The effectiveness of the suggested strategy in attaining accurate osteosarcoma LND is demonstrated by the experimental findings. Chebyshev filtering is incorporated during the pre-processing step, which leads to more accurate detection findings by improving the signal-to-noise ratio (SNR) and lung nodule visibility. Conclusion: Additionally, the improved EfficientDet model demonstrates its suitability for clinical applications in early osteosarcoma detection and treatment monitoring by achieving (SOTA) State-Of-The-Art execution by the metrics of sensitivity, specificity, and F1 score.

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Improving survival after pulmonary metastasectomy for sarcoma: analysis of prognostic factors

Shell

2023

Gen Thorac Cardiovasc Surg

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Prognostic significance of the ratio of surgically resected to radiologically detected lung nodules in patients with metastatic osteosarcoma

Cited by 3 publications

References 22 publications

Survival outcomes and surgical morbidity based on surgical approach to pulmonary metastasectomy in pediatric, adolescent and young adult patients with osteosarcoma

Survival outcomes and surgical morbidity based on surgical approach to pulmonary metastasectomy in pediatric, adolescent and young adult patients with osteosarcoma

Advancements in Image Enhancement and Attention based efficientdet Optimization Classifier for Precise Osteosarcoma Lung Nodule Detection

Improving survival after pulmonary metastasectomy for sarcoma: analysis of prognostic factors

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