Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix

Abstract

Cases of invasive carcinoma of the uterine cervix were analyzed to determine whether the presence or absence of human papillomavirus (HPV) DNA in the neoplasms was a contributing factor to their outcome. The presence of HPV DNA was evaluated using in situ hybridization on formalin-fixed, paraffin-embedded tissue sections. Eighty-five patients with cervical carcinoma who had been surgically evaluated were included in the study. Data from these patients was analyzed retrospectively to determine survival, recurrence, presence of nodal metastases, tumor grade, mode of therapy, peritoneal fluid cytologic results, and age in relation to presence or absence of HPV DNA. No significant statistical differences were found between the HPV-16-positive, HPV-18-positive, and HPV DNA-negative patients.

Different outcome of invasive cervical cancer associated with high‐risk versus intermediate‐risk HPV genotype

“…. ), present in low grade cervical intraepithelial neoplasia (CIN) but rare in invasive cancer, intermediaterisk HPVs (HPV 31,33,35, 51, 52, 58. . .…”

“…23,[29][30][31] The second point concerns the differential prognostic value of HPV genotypes in invasive cancer. We 16 and others 14,22,28,[32][33][34][35][36][37][38][39][40] reported an unfavourable outcome of tumours associated with HPV18 as compared with those associated with HPV16 or with intermediate-risk HPV types. In this work, based on the analysis of a larger number of cases with a long follow up, the better outcome of tumours associated with intermediate-risk HPV was confirmed, but the respective prognostic value of HPV18 vs. HPV16 showed little differences.…”

“…In multivariate analysis, node involvement (p < 0.0001), parametria invasion (p 5 0.009), tumour size (p 5 0.01) and HPV status (p 5 0.02) were associated with disease-free survival (median follow-up 95 months). Disease outcome was better in tumours associated with intermediate risk HPV types (HPV 31,33,35,39, 52, 53, 58, 59, 73) than in tumours with high oncogenic types (HPV 16, 18, 45) (p 5 0.03). Node status and tumour size remained prognostic factor for overall survival.…”

Impact of multiple HPV infection on response to treatment and survival in patients receiving radical radiotherapy for cervical cancer

“…Although some studies reported a poorer prognosis if no HPV virus was detected, 9 -11 other authors came to different conclusions. [12][13][14][15][16][17] The presence of HPV type 18 has been identified as a predictor of early recurrence and poor survival. [5][6][7][8] A recent study found improved survival in patients with HPV 58 positive tumors.…”

“…[5][6][7][8] For other HPV types, the absence of detected HPV DNA sequences was reported to be associated with poor prognosis, 9 -11 whereas others found no relationship between HPV and outcome. [12][13][14][15][16][17] Most of these studies included patients who had received either surgery or a combination of surgery and radiotherapy. Although the standard treatment of locally advanced cervical cancer includes radiotherapy, little is known about the impact of HPV on the response to radiotherapy and on the patients' clinical outcome.…”