Prognostic significance of the preoperative lymphocyte to C‐reactive protein ratio in patients with stage <scp>III</scp> colorectal cancer

Eren, Tunç

doi:10.1111/ans.17896

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…CRP is a well-recognized hallmark of inflammation and has been shown to be an adequate inflammation-based and feasible prognostic marker for CRC, whereby increased plasma levels are associated with a worse prognosis for CRC [ 71 , 72 ], larger tumor size [ 63 ], higher recurrence rates [ 73 ], and decreased overall survival [ 63 ]. As with IL-6, elevated preoperative serum levels were found to be predictive of the malignant potential of the tumor in CRC patients [ 72 , 74 ].…”

Section: Vat and Cancer: The Evidence So Farmentioning

confidence: 99%

Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?

Chaplin

Rodríguez

Segura-Sampedro

et al. 2022

IJMS

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Colorectal cancer (CRC) is a major health problem worldwide, with an estimated 1.9 million new cases and 915,880 deaths in 2020 alone. The etiology of CRC is complex and involves both genetic and lifestyle factors. Obesity is a major risk factor for CRC, and the mechanisms underlying this link are still unclear. However, the generalized inflammatory state of adipose tissue in obesity is thought to play a role in the association between CRC risk and development. Visceral adipose tissue (VAT) is a major source of proinflammatory cytokines and other factors that contribute to the characteristic systemic low-grade inflammation associated with obesity. VAT is also closely associated with the tumor microenvironment (TME), and recent evidence suggests that adipocytes within the TME undergo phenotypic changes that contribute to tumor progression. In this review, we aim to summarize the current evidence linking obesity and CRC, with a focus on the role of VAT in tumor etiology and progression.

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Section: Vat and Cancer: The Evidence So Farmentioning

confidence: 99%

Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?

Chaplin

Rodríguez

Segura-Sampedro

et al. 2022

IJMS

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“…impact of the LCR in patients with CRC (TableVI)(121)(122)(123)(124). Among them, three studies evaluated patients in the surgical setting and one study evaluated patients in the chemotherapy setting.…”

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confidence: 99%

Clinical Impact of Nutrition and Inflammation Assessment Tools in Colorectal Cancer Treatment

AOYAMA,

YUKAWA,

SAITO

2024

Anticancer Res

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For resectable colorectal cancer (CRC), the standard treatment is perioperative adjuvant treatment and complete resection. For unresectable CRC, the standard treatment is systemic chemotherapy. The detection of promising biomarkers is necessary for optimizing the management of CRC and improving patient survival. If physicians can detect useful biomarkers, patients with CRC may benefit from more aggressive or less toxic treatment. Recent studies have shown that the inflammatory and nutritional status both influence the short and long-term oncological outcomes of patients with CRC during perioperative and/or chemotherapy. The utility of several tools for the evaluation of the inflammation and nutritional status has been reported. The introduction of such tools in the management of CRC could have a beneficial impact on postoperative surgical complications or adverse events of chemotherapy. An understanding of the characteristics of each of these evaluations is necessary for their introduction in daily clinical practice. The present report summarizes the background and current status of nutrition and inflammation evaluation tools and future perspectives on their application in the management of patients with CRC.Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide (1, 2). Curative resection and perioperative adjuvant treatment are standard treatments for resectable CRC, while chemotherapy is the standard treatment for unresectable CRC (3, 4). The prognosis of CRC is gradually improving, and the survival of more than half of patients with CRC is limited and poor after diagnosis. Therefore, CRC patients with risk factors for recurrence require more aggressive treatment and management.Recently, the nutritional and inflammatory status during treatment has been recognized as an important factor for both short-and long-term oncological outcomes in various malignancies (5-7). So far, various nutritional and inflammation assessment tools, such as the Glasgow Prognostic Score (GPS), Prognostic Nutritional Index (PNI), Controlling Nutritional Status (CONUT score), C-reactive protein Albumin ratio (CAR), and Albumin/Globulin Ratio (AGR), have been developed and evaluated in gastrointestinal cancers, including CRC. If physicians introduce these nutritional and inflammation assessment tools in daily clinical practice, CRC patients may be able to receive optimized treatments that are more aggressive in comparison to standard treatment. However, each nutritional and inflammatory evaluation tool has its own clinical characteristics. Therefore, physicians need to understand the characteristics of each nutritional and inflammation evaluation tool before their introduction into daily clinical practice.This review summarizes the background, current status, and future perspectives of nutritional and inflammatory assessment tools for CRC treatment. Clinical Impact of the Glasgow Prognostic Score (GPS) for CRC TreatmentThe Glasgow Prognostic Score (GPS) was first reported b...

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Prediction of postoperative infectious complications in elderly patients with colorectal cancer: a study based on improved machine learning

Tian,

Li,

Wang

et al. 2024

BMC Med Inform Decis Mak

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Background Infectious complications after colorectal cancer (CRC) surgery increase perioperative mortality and are significantly associated with poor prognosis. We aimed to develop a model for predicting infectious complications after colorectal cancer surgery in elderly patients based on improved machine learning (ML) using inflammatory and nutritional indicators. Methods The data of 512 elderly patients with colorectal cancer in the Third Affiliated Hospital of Anhui Medical University from March 2018 to April 2022 were retrospectively collected and randomly divided into a training set and validation set. The optimal cutoff values of NLR (3.80), PLR (238.50), PNI (48.48), LCR (0.52), and LMR (2.46) were determined by receiver operating characteristic (ROC) curve; Six conventional machine learning models were constructed using patient data in the training set: Linear Regression, Random Forest, Support Vector Machine (SVM), BP Neural Network (BP), Light Gradient Boosting Machine (LGBM), Extreme Gradient Boosting (XGBoost) and an improved moderately greedy XGBoost (MGA-XGBoost) model. The performance of the seven models was evaluated by area under the receiver operator characteristic curve, accuracy (ACC), precision, recall, and F1-score of the validation set. Results Five hundred twelve cases were included in this study; 125 cases (24%) had postoperative infectious complications. Postoperative infectious complications were notably associated with 10 items features: American Society of Anesthesiologists scores (ASA), operation time, diabetes, presence of stomy, tumor location, NLR, PLR, PNI, LCR, and LMR. MGA-XGBoost reached the highest AUC (0.862) on the validation set, which was the best model for predicting postoperative infectious complications in elderly patients with colorectal cancer. Among the importance of the internal characteristics of the model, LCR accounted for the highest proportion. Conclusions: This study demonstrates for the first time that the MGA-XGBoost model with 10 risk factors might predict postoperative infectious complications in elderly CRC patients.

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Prognostic significance of the preoperative lymphocyte to C‐reactive protein ratio in patients with stage III colorectal cancer

Cited by 4 publications

References 36 publications

Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?

Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?

Clinical Impact of Nutrition and Inflammation Assessment Tools in Colorectal Cancer Treatment

Prediction of postoperative infectious complications in elderly patients with colorectal cancer: a study based on improved machine learning

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