Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer: A systematic review and meta-analysis

Takagi, Kosei; Buettner, Stefan; IJzermans, Jan N.M.

doi:10.1016/j.ijsu.2020.04.046

Cited by 61 publications

(65 citation statements)

References 31 publications

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“…The results demonstrated that high-CONUT has a poor impact on OS and RFS in HCC patients. Takagi et al (34,35) also conducted another two meta-analyses exploring the prognostic value of CONUT in gastric and colorectal cancer. The results revealed that both gastric and colorectal cancer patients with a high-COUNT score had reduced OS, CSS and RFS.…”

Section: Discussionmentioning

confidence: 99%

Controlling nutritional status is a prognostic factor for patients with lung cancer: a systematic review and meta-analysis

Zhang¹,

Li²,

Cong³

et al. 2021

Ann Palliat Med

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Background: Nowadays, controlling nutritional status (CONUT) has been used as a prognostic factor in variety of cancers. However, no consensus has been reached on the prognostic value of CONUT in lung cancer. In this study, we aim to investigate the role of CONUT in survival of patients with lung cancer.Methods: EMBASE, web of science, and Medline were used to search articles in English-language journals.The association between CONUT score and survival of patients with lung cancer was evaluated by using pooled HRs and their 95% CIs. Chi-square test and I-Square was used to test heterogeneity among studies.Analyses were all performed using Stata 13.0 (Stata Corporation, College Station, TX).Results: Eight studies with 1,836 patients were eventually included in this meta-analysis. The pooled results showed that high CONUT score had an unfavorable impact on OS (HR =1.63, 95% CI: 1.30-2.04),

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Section: Discussionmentioning

confidence: 99%

Controlling nutritional status is a prognostic factor for patients with lung cancer: a systematic review and meta-analysis

Zhang¹,

Li²,

Cong³

et al. 2021

Ann Palliat Med

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“…12 With the deepening of its research, people found that the CONUT score has significant prognostic value in various malignant tumors, such as esophageal, 13 renal, 14 gastric, 15 prostate, 16 and colorectal cancer. 17 However, no study has systematically identified the prognostic effect of preoperative CONUT score on post-treatment RFS in patients with NMBIC cancer.…”

Section: Discussionmentioning

confidence: 99%

Development of a New Recurrence-Free Survival Prediction Nomogram for Patients with Primary Non-Muscle-Invasive Bladder Cancer Based on Preoperative Controlling Nutritional Status Score

Zhao¹,

Sun²,

Wang³

et al. 2021

CMAR

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Background Bladder cancer is the second most prevalent neoplasm in the urogenital system in terms of morbidity and mortality, and there is an urgent need for a more accurate assessment of individual prognosis in patients with primary non-muscle-invasive bladder cancer (NMIBC). The Controlling Nutritional Status (CONUT) score is an emerging biomarker score which has been confirmed to have prognostic value in various malignant tumors. The study attempted to systematically identify the prognostic role of preoperative CONUT score on posttreatment recurrence-free survival (RFS) in patients with NMIBC, and determine the predictive value and feasibility of the new prognostic prediction model. Methods A total of 94 patients with NMIBC were analyzed retrospectively between January 2011 and December 2015. Statistical analysis was conducted using the nonparametric method. The Kaplan-–Meier method was used to assess recurrence-free survival (RFS), and Log rank tests was used to analyze the equivalences of survival curves. We used univariate and multivariate Cox proportional hazards regression model to identify important predictors of RFS. Discrimination of nomogram was measured by the concordance index. Predictive accuracy of the model was evaluated using the internal validation. Results In univariate analysis, age, history of smoking, pathological T stage, tumor grade, tumor size, and CONUT score were significantly correlated with RFS. Multivariate analysis indicated that CONUT score (HR =3.855, 95% CI 1.242–11.970, p=0.020) was an independent predictor of RFS in patients with NMIBC. Based on significant parameters in multivariate analysis and reliable recurrence predictors determined in predictive models and relevant guidelines, a new age-, history of smoking-, pathologic factors- and the CONUT score-based scoring model was developed to predict recurrence of NMBIC. In addition, we internally validated the nomogram using the consistency index and calibration plots, which demonstrated that the model has high prediction accuracy (c-index= 0.851). Conclusion The development of a new nomogram based on CONUT score could increase the accuracy of recurrence prediction and improve individualized treatment plans for patients with NMIBC.

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“…The CONUT score was initially reported as an effective tool for early detection and ongoing control of malnutrition in hospitals [12]. With the deepening of its research, people found that the CONUT score has signi cant prognostic value in various malignant tumors, such as esophageal [13], renal [14], gastric [15], prostate [16], and colorectal cancer [17]. However, no study has systematically identi ed the prognostic effect of preoperative CONUT score on posttreatment RFS in patients with NMBIC cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The scoring system is readily available and signi cantly correlated with both Subjective Global Assessment (SGA) and Full Nutritional Assessment (FNA) [12]. In addition, it has been reported to be associated with the postoperative complications and prognosis of various malignant tumors [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Development of a new recurrence-free survival prediction nomogram for patients with primary non-muscle-invasive bladder cancer based on preoperative controlling nutritional status score

Zhao

Huang

Sun

et al. 2021

Preprint

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Bladder cancer is the second most common neoplasm in the urogenital system in terms of morbidity and mortality, and there is an urgent need for a more accurate assessment of the individual prognosis in patients with primary non-muscle-invasive bladder cancer (NMIBC). The Controlling Nutritional Status (CONUT) score is an emerging biomarker score, which has been confirmed to have prognostic value in various malignant tumors. A total of 94 patients with NMIBC were analyzed retrospectively between January 2011 and December 2015.The Kaplan-Meier method was used to assess recurrence-free survival (RFS), and log-rank tests was used to test the equivalences of survival curves. We used univariate and multivariate Cox proportional hazards regression model to identify important predictors of RFS. In univariate analysis, age, history of smoking, pathological T stage, tumor grade, tumor size, and CONUT score were significantly correlated with RFS. Multivariate analysis indicated that CONUT score(HR = 3.855, 95% CI 1.242–11.970, p = 0.020) was an independent predictor of RFS in patients with NMIBC. Based on significant parameters in multivariate analysis and reliable recurrence predictors determined in predictive models and relevant guidelines, a new age-, history of smoking-, pathologic factors- and the CONUT score-based scoring model was developed to predict recurrence of NMBIC. In addition, we internally validated the nomogram using the consistency index and calibration plots, which showed the model has high prediction accuracy(c-index = 0.851). The development of a new nomogram based on CONUT score could increase the accuracy of recurrence prediction and improve individualized treatment plan for patients with NMIBC.

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Prognostic significance of the controlling nutritional status (CONUT) score in patients with colorectal cancer: A systematic review and meta-analysis

Cited by 61 publications

References 31 publications

Controlling nutritional status is a prognostic factor for patients with lung cancer: a systematic review and meta-analysis

Controlling nutritional status is a prognostic factor for patients with lung cancer: a systematic review and meta-analysis

Development of a New Recurrence-Free Survival Prediction Nomogram for Patients with Primary Non-Muscle-Invasive Bladder Cancer Based on Preoperative Controlling Nutritional Status Score

Development of a new recurrence-free survival prediction nomogram for patients with primary non-muscle-invasive bladder cancer based on preoperative controlling nutritional status score

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