Prognostic Significance of the angiopoietin-2 for Early Prediction of Septic Shock in Severe Sepsis Patients

Duyen, Luu Thi Thanh; Manh, Bui Van; Thảo, Trần Thị Phương; Khanh, Le Van; Trang, Bui Ngoc Linh; Giang, Ngo Truong; Quang, Ha Van; Viet, Nguyen Thanh; Hang, Ngo Thu; Mao, Can Van; Toàn, Nguyễn Lĩnh; Tong, Hoang Van

doi:10.2144/fsoa-2022-0077

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…Plasma Ang-2 levels may serve as an additional biomarker for severe sepsis and septic shock. 57 One study included 102 patients with sepsis and suspected DIC demonstrates that Ang-2 levels are significantly upregulated in SIC, and this biomarker can be used to risk stratify patients with sepsis into overt DIC and non-overt DIC. Furthermore, the Ang-2 level at ICU admission in a patient with sepsis and suspected DIC may provide a predictive biomarker for mortality outcome.…”

Section: Potential Biomarkers For Sicmentioning

confidence: 99%

Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy

Li,

Wang

et al. 2023

Clin Appl Thromb Hemost

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Sepsis-induced coagulopathy (SIC) is a life-threatening complication characterized by the systemic activation of coagulation in sepsis. The diagnostic criteria of SIC consist of three items, including Sequential Organ Failure Assessment (SOFA) score, platelet count, and prothrombin time (PT)-international normalized ratio (INR). SIC has a high prevalence and it can lead to a higher mortality rate and longer length of hospital and ICU stay. Thus, the early detection of SIC is extremely important. It is unfortunate that there is still no precise biomarker for early diagnosis and assessment of the prognosis of SIC. We reviewed the current literature and discovered that some potential biomarkers, such as soluble thrombomodulin (sTM), thrombin–antithrombin complex (TAT), tissue plasminogen activator-inhibitor complex (t-PAIC), α2-plasmin inhibitor-plasmin complex (PIC), C-type lectin-like receptor 2 (CLEC-2), neutrophil extracellular traps (NETs), prothrombin fragment 1.2 (F1.2), Angiopoietin-2 (Ang-2), plasminogen activator inhibitor-1 (PAI-1), and tissue inhibitor of metalloproteinase-1 (TIMP-1) may be useful for early diagnosis, evaluation, and prognosis of SIC. Early initiation of treatment without missing any therapeutic opportunities may improve SIC patients’ prognosis. Further large-scale clinical studies are still needed to confirm the role of these biomarkers in the diagnosis and prognosis assessment of SIC.

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Section: Potential Biomarkers For Sicmentioning

confidence: 99%

Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy

Li,

Wang

et al. 2023

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

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Navigating the Modern Landscape of Sepsis: Advances in Diagnosis and Treatment

Jang,

Choi,

Kim

et al. 2024

IJMS

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Sepsis poses a significant threat to human health due to its high morbidity and mortality rates worldwide. Traditional diagnostic methods for identifying sepsis or its causative organisms are time-consuming and contribute to a high mortality rate. Biomarkers have been developed to overcome these limitations and are currently used for sepsis diagnosis, prognosis prediction, and treatment response assessment. Over the past few decades, more than 250 biomarkers have been identified, a few of which have been used in clinical decision-making. Consistent with the limitations of diagnosing sepsis, there is currently no specific treatment for sepsis. Currently, the general treatment for sepsis is conservative and includes timely antibiotic use and hemodynamic support. When planning sepsis-specific treatment, it is important to select the most suitable patient, considering the heterogeneous nature of sepsis. This comprehensive review summarizes current and evolving biomarkers and therapeutic approaches for sepsis.

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Prognostic Significance of the angiopoietin-2 for Early Prediction of Septic Shock in Severe Sepsis Patients

Cited by 2 publications

References 40 publications

Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy

Potential Biomarkers for Early Diagnosis, Evaluation, and Prognosis of Sepsis-Induced Coagulopathy

Navigating the Modern Landscape of Sepsis: Advances in Diagnosis and Treatment

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