Prognostic Significance of T-Cell or Cytotoxic Molecules Phenotype in Classical Hodgkin’s Lymphoma: A Clinicopathologic Study

Asano, Naoki; Oshiro, Aya; Matsuo, Keitaro; Kagami, Yoshitoyo; Ishida, Fumihiro; Suzuki, Ritsuro; Kinoshita, Tomohiro; Shimoyama, Yoshie; Tamaru, Jun Ichi; Yoshino, Tadashi; Kïtamura, Kazuo; Fukutani, H; Morishima, Yasuo; Nakamura, Shigeo

doi:10.1200/jco.2006.06.5342

Cited by 82 publications

(64 citation statements)

References 27 publications

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“…However, BNLI grade was not prognostic for the OS outcome (data not shown), which is consistent with results from another Asian study [31]. Previous studies on BNLI grading have yielded contradictory results [32][33][34][35][36][37][38][39].…”

Section: Discussionsupporting

confidence: 81%

The Ratio of the Absolute Lymphocyte Count to the Absolute Monocyte Count Is Associated with Prognosis in Hodgkin's Lymphoma: Correlation with Tumor-Associated Macrophages

et al. 2012

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Background. Although most patients with classical Hodgkin's lymphoma (cHL) have a long survival duration, the current risk stratification is imperfect. A recent study suggested a prognostic role for the peripheral blood absolute lymphocyte count/absolute monocyte count (ALC/AMC) ratio at diagnosis in cHL. It is intriguing to investigate the significance of the ALC/AMC ratio in relation to tumor-associated macrophages (TAMs), yet another prognostic factor for cHL.Methods. We examined the prognostic impact of the ALC, AMC, and ALC/AMC ratio in 312 cHL patients (median age, 37 years) using receiver operating characteristic curve analysis for optimal cutoff values, and compared these with TAM content.Results. The median follow-up was 65 months (range, 0.1-245 months). On univariate analysis, a low ALC/AMC

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Section: Discussionsupporting

confidence: 81%

The Ratio of the Absolute Lymphocyte Count to the Absolute Monocyte Count Is Associated with Prognosis in Hodgkin's Lymphoma: Correlation with Tumor-Associated Macrophages

et al. 2012

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“…This series included 324 patients with CHL and 41 with cytotoxic molecule-positive PTCL-N who had been examined in our previous study. 19,21 Approval for the study was provided by the institutional review board of Nagoya University.…”

Section: Selection Of Patientsmentioning

confidence: 99%

“…We also recently highlighted that the expression of T-cell antigen and cytotoxic molecules, either singly or in combination, is an independent poor prognostic factor in CHL. 21 To our knowledge, however, no comprehensive evaluation of the clinical characteristics of cytotoxic molecule-positive CHL has yet been reported.…”

Section: Introductionmentioning

confidence: 99%

“…21 These findings suggest that the expression of cytotoxic molecules on lymphoma cells might be associated with poorer overall survival among patients with nodal CHL and PTCL-N. We, therefore, also compared the clinicopathological profiles of patients with CHL and PTCL-N, who share cytotoxic molecule expression and nodal presentation. This analysis identified several significant clinical differences between the two groups.…”

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confidence: 99%

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Cytotoxic molecule-positive classical Hodgkin's lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type

Asano¹,

Kinoshita²,

Tamaru³

et al. 2011

Haematologica

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BackgroundClassical Hodgkin's lymphoma is characterized by Hodgkin and Reed Sternberg cells, which are of B-cell origin in many cases. We recently highlighted the adverse prognostic significance of cytotoxic molecule expression in patients with classical Hodgkin's lymphoma. However, the clinical characteristics of cytotoxic molecule-positive classical Hodgkin's lymphoma remain controversial. Design and MethodsWe investigated the clinicopathological profiles of 32 patients with cytotoxic molecule-positive Hodgkin's lymphoma, comprising 23 with nodular sclerosis and 9 with mixed cellularity, and compared these profiles with those of 55 patients with cytotoxic molecule-positive nodal peripheral T-cell lymphoma, not otherwise specified and 439 patients with cytotoxic moleculenegative Hodgkin's lymphoma. ResultsThe patients with cytotoxic molecule-positive Hodgkin's lymphoma consisted of 20 men and 12 women with a median age of 50 years (range, 19 to 81). All these patients had lymphadenopathy at presentation, and 14 showed mediastinal involvement. Physical findings included hepatomegaly and splenomegaly in six patients each. Four patients had a bulky mass, and nine showed stage IV disease. The tumor cells of patients with cytotoxic molecule-positive Hodgkin's lymphoma had a prototypic immunophenotype of CD15 + CD30 + CD45RO -fascin + , with positivity for Epstein-Barr virus in 39% of cases. All patients were negative for Pax5. In comparison with patients with cytotoxic molecule-positive nodal peripheral T-cell lymphomas, not otherwise specified, patients with cytotoxic-positive Hodgkin's lymphoma had relatively mild clinical symptoms, similar to those of patients with cytotoxic molecule-negative Hodgkin's lymphoma. Regarding prognosis, the survival of patients with cytotoxic moleculepositive Hodgkin's lymphoma was worse than that of patients with cytotoxic molecule-negative Hodgkin's lymphoma (P=0.0003) but better than that of patients with cytotoxic moleculepositive peripheral T-cell lymphomas, not otherwise specified (P=0.002). ConclusionsCytotoxic molecule-positive Hodgkin's lymphoma is characterized by an unfavorable prognosis, even if its clinicopathological features are within the boundaries of classical Hodgkin's lymphoma. More effective chemotherapy for cytotoxic molecule-positive Hodgkin's lymphoma is clearly required. Haematologica 2011;96(11):1636-1643. doi:10.3324/haematol.2011 ©2011 Ferrata Storti Foundation. This is an open-access paper.Cytotoxic molecule-positive classical Hodgkin's lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type

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“…3,4,5 Taking into the consideration that some classical Hodgkin lymphomas may even express cytotoxic molecules, differential diagnosis between classical Hodgkin lymphoma and anaplastic large cell lymphoma may be challenging. 10 Fascin appears to have a limited usefulness in the differential diagnosis between these two entities as its negativity may help the exclusion of classical Hodgkin lymphoma. 2,5,9 Fascin staining was observed in 34 of 55 (61.8%) DLBCLs in our study and 20 (36.3%) of them were diffuse strong.…”

Section: Discussionmentioning

confidence: 99%

Does Fascin Expression in Diffuse Large B-Cell Lymphomas have a Clinical Impact in Patients Treated with Anthracyclin-Based Chemotherapy Plus Rituximab?

Köse¹,

Kayaselçuk²,

Beşen³

et al. 2013

UHOD

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Fascin is an actin-bundling protein that is expressed by dendritic cells of the lymphoid tissue. Fascin expression is also seen in the neoplastic cells of classical Hodgkin lymphomas, nearly half of the anaplastic lymphomas and in some diffuse large B-cell lymphomas. We aimed to investigate the clinical significance of fascin expression in CD20 positive diffuse large B-cell lymphomas (DLBCL) in patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone plus rituximab (R-CHOP). Thirtyfour of the 55 patients included in the study showed fascin expression, 16 of them being diffuse and strong. There was no statistically significant correlation between fascin expression and overall survival and disease-free survival, sex, disease stage, chemotherapy response, whether or not having bulky disease, extranodal involvement, and international prognostic index (IPI) score. The study has failed to show prognostic significance of fascin expression in DLBCL patients treated with R-CHOP. However, because of the alterations in fascin expression in a variety of benign and malignant lymphoid entities, regardless of its prognostic impact, studies on fascin expression may help us to understand tumor biology of lymphomas better. Fascin, lenfoid dokunun dendritik hücreleri taraf›ndan eksprese edilen, aktin paketleyici bir proteindir. Klasik Hodgkin lenfomalar›n neoplastik hücrelerinin, anaplastik lenfomalar›n yaklafl›k yar›s›n›n ve diffüz büyük B-hücreli lenfomalar›n bir k›sm›n›n da fascin eksprese etti¤i gösterilmifltir. Bu çal›flman›n amac›, siklofosfamid, doksorubisin, vinkristin, prednizolon ile birlikte rituksimab (R-CHOP) tedavisi alan CD20 pozitif diffüz büyük B-hücreli lenfomal› (DBBHL) hastalarda fascin ekspresyonunun klinik önemi olup olmad›¤›n› ortaya koymakt›r. Çal›flmaya dahil edilen 55 hastaya ait tümör örneklerinin 34'ünde immünhistokimyasal yöntemle fascin pozitifli¤i saptand›. Otuzdört vakan›n 16's›ndaki pozitiflik yayg›n ve kuvvetli idi. ‹statistiksel de¤erlendirmede fascin ekspresyonu ile toplam yaflam süre-si, hastal›ks›z yaflam süresi, cinsiyet, hastal›¤›n evresi, kemoterapiye yan›t, bulky hastal›k olup olmamas›, ekstranodal tutulum ve enternasyonal prognostik indeks (IPI) skoru aras›nda anlaml› bir iliflki saptanmad›. Çal›flmada R-CHOP tedavisi alan DBBHL'l› hastalarda fascin ekspresyonun prognostik önemi oldu¤una dair bulgu saptanmam›flt›r. Farkl› benign ve malign lenfoid antitelerde fascin ekspresyonunda bildirilen de¤ifliklikler ve ayn› hastal›¤a sahip hastalarda saptanan ekspresyon farkl›l›klar›, prognostik önemi olmasa da, fascin üzerine yap›lacak çal›flmalar›n lenfomalar›n tümör biyolojisini daha iyi anlamam›za yard›mc› olaca¤›n› düflündürmektedir.

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Prognostic Significance of T-Cell or Cytotoxic Molecules Phenotype in Classical Hodgkin’s Lymphoma: A Clinicopathologic Study

Cited by 82 publications

References 27 publications

The Ratio of the Absolute Lymphocyte Count to the Absolute Monocyte Count Is Associated with Prognosis in Hodgkin's Lymphoma: Correlation with Tumor-Associated Macrophages

The Ratio of the Absolute Lymphocyte Count to the Absolute Monocyte Count Is Associated with Prognosis in Hodgkin's Lymphoma: Correlation with Tumor-Associated Macrophages

Cytotoxic molecule-positive classical Hodgkin's lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type

Does Fascin Expression in Diffuse Large B-Cell Lymphomas have a Clinical Impact in Patients Treated with Anthracyclin-Based Chemotherapy Plus Rituximab?

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